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Gene ID: 51107 | APH1A Antibody Resource


APH1A Antibody Resource
Gene Full Name: 
APH1A gamma secretase subunit
Uniprot: 
Q96BI3
Protein Name: 
gamma-secretase subunit APH-1A
Nucleotide: 
NR_045034
Alias: 
APH-1;APH-1A;CGI-78;6530402N02Rik;
Ensembl: 
ENSG00000117362
Location: 
1p36.13-q31.3
HPRD: 
NCBI Gene: 
51107
MIM: 
607629

Summary: 
This gene encodes a component of the gamma secretase complex that cleaves integral membrane proteins such as Notch receptors and beta-amyloid precursor protein. The gamma secretase complex contains this gene product, or the paralogous anterior pharynx defective 1 homolog B (APH1B), along with the presenilin, nicastrin, and presenilin enhancer-2 proteins. The precise function of this seven-transmembrane-domain protein is unknown though it is suspected of facilitating the association of nicastrin and presenilin in the gamma secretase complex as well as interacting with substrates of the gamma secretase complex prior to their proteolytic processing. Polymorphisms in a promoter region of this gene have been associated with an increased risk for developing sporadic Alzheimer's disease. Alternative splicing results in multiple protein-coding and non-protein-coding transcript variants. [provided by RefSeq, Aug 2011]
Function: 
Essential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (beta-amyloid precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex.
Subcellular location: 
Endoplasmic reticulum membrane; Multi-pass membrane protein. Golgi apparatus › Golgi stack membrane; Multi-pass membrane protein. Note: Predominantly located in the endoplasmic reticulum and in the cis-Golgi.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB01161 APH1A Antibody (OAEB01161) Bovine, Human, Mouse, Pig, Rabbit, Rat WB 0.1mg $289 Details
Polyclonal Antibody ARP45011_P050 APH1A Antibody (ARP45011_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAAB14718 APH1A antibody - N - terminal region (OAAB14718) Mouse WB 400ul $289 Details
Polyclonal Antibody OAAB16614 APH1 antibody - N - terminal region (OAAB16614) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAAB16615 APH1 antibody - C - terminal region (OAAB16615) Human; Mouse WB 400ul $289 Details

Show all APH1A antibodies


Product Images
APH1A antibody - N - terminal region (OAAB14718) in Mouse Liver cells using Western Blot

Sample Type: Mouse Liver

APH1 antibody - N - terminal region (OAAB16614) in A2058 cells using Western Blot

Sample Type: A2058

APH1 antibody - N - terminal region (OAAB16614) in Human hepatocarcinoma cells using Immunohistochemistry

Sample Type: Human hepatocarcinoma

APH1A Antibody (OAEB01161) in Human Brain cells using Western Blot

Sample Type: Human Brain


APH1A Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP45011 African clawed frog APH1A antibody; Xenopus laevis APH1A antibody Q5HZF9 79.0%
ARP45011 Bovine APH1A antibody; Bos taurus APH1A antibody Q3SZ69 100.0%
ARP45011 Cat APH1A antibody; Felis catus APH1A antibody M3XG97 100.0%
ARP45011 Chicken APH1A antibody; Gallus gallus APH1A antibody E1C2N9 91.0%
ARP45011 Chimpanzee APH1A antibody; Pan troglodytes APH1A antibody H2R2D2 100.0%
ARP45011 Chinese softshell turtle APH1A antibody; Pelodiscus sinensis APH1A antibody K7FY54 93.0%
ARP45011 Collared flycatcher APH1A antibody; Ficedula albicollis APH1A antibody U3JHL2 91.0%
ARP45011 European domestic ferret APH1A antibody; Mustela putorius furo APH1A antibody M3Y1J8 100.0%
ARP45011 Giant panda APH1A antibody; Ailuropoda melanoleuca APH1A antibody D2HBU9 100.0%
ARP45011 Gray short-tailed opossum APH1A antibody; Monodelphis domestica APH1A antibody F7ADK5 100.0%
ARP45011 Horse APH1A antibody; Equus caballus APH1A antibody F6ZP32 100.0%
ARP45011 Human APH1A antibody; Homo sapiens APH1A antibody Q5TB21 100.0%
ARP45011 Human APH1A antibody; Homo sapiens APH1A antibody Q96BI3-2 100.0%
ARP45011 Human APH1A antibody; Homo sapiens APH1A antibody Q96BI3-3 100.0%
ARP45011 Human APH1A antibody; Homo sapiens APH1A antibody Q96BI3 100.0%
ARP45011 Mouse APH1A antibody; Mus musculus APH1A antibody Q6GTF1 100.0%
ARP45011 Mouse APH1A antibody; Mus musculus APH1A antibody Q8BVF7-2 100.0%
ARP45011 Mouse APH1A antibody; Mus musculus APH1A antibody Q8BVF7 100.0%
ARP45011 Mouse APH1A antibody; Mus musculus APH1A antibody Q3U886 93.0%
ARP45011 Pig APH1A antibody; Sus scrofa APH1A antibody I3L8R2 100.0%
ARP45011 Rabbit APH1A antibody; Oryctolagus cuniculus APH1A antibody G1SWE2 100.0%
ARP45011 Rat APH1A antibody; Rattus norvegicus APH1A antibody Q5PQQ3 100.0%
ARP45011 Rhesus macaque APH1A antibody; Macaca mulatta APH1A antibody F7FDJ2 100.0%
ARP45011 Rhesus macaque APH1A antibody; Macaca mulatta APH1A antibody F7FDJ7 100.0%
ARP45011 Rhesus macaque APH1A antibody; Macaca mulatta APH1A antibody F7FDK4 100.0%
ARP45011 Rhesus macaque APH1A antibody; Macaca mulatta APH1A antibody G7MDH0 100.0%
ARP45011 Small-eared galago APH1A antibody; Otolemur garnettii APH1A antibody H0WQS6 100.0%
ARP45011 Sumatran orangutan APH1A antibody; Pongo abelii APH1A antibody H2N601 100.0%
ARP45011 Tasmanian devil APH1A antibody; Sarcophilus harrisii APH1A antibody G3W524 93.0%
ARP45011 Thirteen-lined ground squirrel APH1A antibody; Spermophilus tridecemlineatus APH1A antibody I3M762 100.0%
ARP45011 Western clawed frog APH1A antibody; Xenopus tropicalis APH1A antibody Q5EB22 79.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody F7B1K5 100.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody F7EDG9 100.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody F7EDV3 100.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody F7GA65 100.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody U3DJW2 100.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody U3DKU7 100.0%
ARP45011 White-tufted-ear marmoset APH1A antibody; Callithrix jacchus APH1A antibody U3DW61 100.0%
ARP45011 Zebra finch APH1A antibody; Taeniopygia guttata APH1A antibody H0YUG4 91.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas218389_s_at721_B_lymphoblasts471.000197.290Details
BioGPS Gene Atlas218389_s_atAdipocyte114.450197.290Details
BioGPS Gene Atlas218389_s_atAdrenalCortex129.900197.290Details
BioGPS Gene Atlas218389_s_atAdrenalgland150.500197.290Details
BioGPS Gene Atlas218389_s_atAmygdala104.850197.290Details
BioGPS Gene Atlas218389_s_atAppendix113.650197.290Details
BioGPS Gene Atlas218389_s_atAtrioventricularNode98.450197.290Details
BioGPS Gene Atlas218389_s_atBDCA4+_DentriticCells444.650197.290Details
BioGPS Gene Atlas218389_s_atBonemarrow119.600197.290Details
BioGPS Gene Atlas218389_s_atBronchialEpithelialCells395.000197.290Details
BioGPS Gene Atlas218389_s_atCD105+_Endothelial123.800197.290Details
BioGPS Gene Atlas218389_s_atCD14+_Monocytes346.100197.290Details
BioGPS Gene Atlas218389_s_atCD19+_BCells(neg._sel.)844.450197.290Details
BioGPS Gene Atlas218389_s_atCD33+_Myeloid531.250197.290Details
BioGPS Gene Atlas218389_s_atCD34+344.100197.290Details
BioGPS Gene Atlas218389_s_atCD4+_Tcells163.550197.290Details
BioGPS Gene Atlas218389_s_atCD56+_NKCells603.450197.290Details
BioGPS Gene Atlas218389_s_atCD71+_EarlyErythroid100.150197.290Details
BioGPS Gene Atlas218389_s_atCD8+_Tcells125.200197.290Details
BioGPS Gene Atlas218389_s_atCardiacMyocytes144.900197.290Details
BioGPS Gene Atlas218389_s_atCaudatenucleus103.050197.290Details
BioGPS Gene Atlas218389_s_atCerebellum101.600197.290Details
BioGPS Gene Atlas218389_s_atCerebellumPeduncles123.000197.290Details
BioGPS Gene Atlas218389_s_atCiliaryGanglion79.500197.290Details
BioGPS Gene Atlas218389_s_atCingulateCortex93.850197.290Details
BioGPS Gene Atlas218389_s_atColorectaladenocarcinoma156.900197.290Details
BioGPS Gene Atlas218389_s_atDorsalRootGanglion83.350197.290Details
BioGPS Gene Atlas218389_s_atFetalThyroid194.800197.290Details
BioGPS Gene Atlas218389_s_atFetalbrain108.400197.290Details
BioGPS Gene Atlas218389_s_atFetalliver143.450197.290Details
BioGPS Gene Atlas218389_s_atFetallung172.100197.290Details
BioGPS Gene Atlas218389_s_atGlobusPallidus81.650197.290Details
BioGPS Gene Atlas218389_s_atHeart574.400197.290Details
BioGPS Gene Atlas218389_s_atHypothalamus136.900197.290Details
BioGPS Gene Atlas218389_s_atKidney152.900197.290Details
BioGPS Gene Atlas218389_s_atLeukemia_chronicMyelogenousK-562155.100197.290Details
BioGPS Gene Atlas218389_s_atLeukemia_promyelocytic-HL-60144.850197.290Details
BioGPS Gene Atlas218389_s_atLeukemialymphoblastic(MOLT-4)191.650197.290Details
BioGPS Gene Atlas218389_s_atLiver466.800197.290Details
BioGPS Gene Atlas218389_s_atLung976.250197.290Details
BioGPS Gene Atlas218389_s_atLymphnode137.950197.290Details
BioGPS Gene Atlas218389_s_atLymphoma_burkitts(Daudi)161.900197.290Details
BioGPS Gene Atlas218389_s_atLymphoma_burkitts(Raji)173.000197.290Details
BioGPS Gene Atlas218389_s_atMedullaOblongata109.550197.290Details
BioGPS Gene Atlas218389_s_atOccipitalLobe81.700197.290Details
BioGPS Gene Atlas218389_s_atOlfactoryBulb90.450197.290Details
BioGPS Gene Atlas218389_s_atOvary81.650197.290Details
BioGPS Gene Atlas218389_s_atPancreas131.200197.290Details
BioGPS Gene Atlas218389_s_atPancreaticIslet114.550197.290Details
BioGPS Gene Atlas218389_s_atParietalLobe110.850197.290Details
BioGPS Gene Atlas218389_s_atPituitary147.550197.290Details
BioGPS Gene Atlas218389_s_atPlacenta231.950197.290Details
BioGPS Gene Atlas218389_s_atPons103.750197.290Details
BioGPS Gene Atlas218389_s_atPrefrontalCortex160.400197.290Details
BioGPS Gene Atlas218389_s_atProstate566.100197.290Details
BioGPS Gene Atlas218389_s_atSalivarygland93.850197.290Details
BioGPS Gene Atlas218389_s_atSkeletalMuscle131.400197.290Details
BioGPS Gene Atlas218389_s_atSkin87.700197.290Details
BioGPS Gene Atlas218389_s_atSmoothMuscle125.600197.290Details
BioGPS Gene Atlas218389_s_atSpinalcord127.950197.290Details
BioGPS Gene Atlas218389_s_atSubthalamicNucleus83.700197.290Details
BioGPS Gene Atlas218389_s_atSuperiorCervicalGanglion131.550197.290Details
BioGPS Gene Atlas218389_s_atTemporalLobe92.300197.290Details
BioGPS Gene Atlas218389_s_atTestis103.450197.290Details
BioGPS Gene Atlas218389_s_atTestisGermCell78.950197.290Details
BioGPS Gene Atlas218389_s_atTestisIntersitial67.900197.290Details
BioGPS Gene Atlas218389_s_atTestisLeydigCell108.050197.290Details
BioGPS Gene Atlas218389_s_atTestisSeminiferousTubule90.500197.290Details
BioGPS Gene Atlas218389_s_atThalamus114.200197.290Details
BioGPS Gene Atlas218389_s_atThymus190.050197.290Details
BioGPS Gene Atlas218389_s_atThyroid590.450197.290Details
BioGPS Gene Atlas218389_s_atTongue125.700197.290Details
BioGPS Gene Atlas218389_s_atTonsil118.500197.290Details
BioGPS Gene Atlas218389_s_atTrachea133.700197.290Details
BioGPS Gene Atlas218389_s_atTrigeminalGanglion110.000197.290Details
BioGPS Gene Atlas218389_s_atUterus115.700197.290Details
BioGPS Gene Atlas218389_s_atUterusCorpus108.000197.290Details
BioGPS Gene Atlas218389_s_atWholeBlood428.800197.290Details
BioGPS Gene Atlas218389_s_atWholebrain118.700197.290Details
BioGPS Gene Atlas218389_s_atcolon333.500197.290Details
BioGPS Gene Atlas218389_s_atpineal_day129.440197.290Details
BioGPS Gene Atlas218389_s_atpineal_night116.620197.290Details
BioGPS Gene Atlas218389_s_atretina228.850197.290Details
BioGPS Gene Atlas218389_s_atsmall_intestine366.050197.290Details
BioGPS NCI60218389_s_at786940.787781.130Details
BioGPS NCI60218389_s_atA1721152.391781.130Details
BioGPS NCI60218389_s_atA204485.406781.130Details
BioGPS NCI60218389_s_atA3611371.395781.130Details
BioGPS NCI60218389_s_atA498681.467781.130Details
BioGPS NCI60218389_s_atA549733.500781.130Details
BioGPS NCI60218389_s_atACC3994.176781.130Details
BioGPS NCI60218389_s_atACHN985.496781.130Details
BioGPS NCI60218389_s_atALVA31791.954781.130Details
BioGPS NCI60218389_s_atCAKI1872.171781.130Details
BioGPS NCI60218389_s_atCCRT CEM597.504781.130Details
BioGPS NCI60218389_s_atCOLO205824.613781.130Details
BioGPS NCI60218389_s_atDLD1865.806781.130Details
BioGPS NCI60218389_s_atDU145768.439781.130Details
BioGPS NCI60218389_s_atEKVX2335.341781.130Details
BioGPS NCI60218389_s_atGM133513.489781.130Details
BioGPS NCI60218389_s_atGM1600443.934781.130Details
BioGPS NCI60218389_s_atGM2313707.020781.130Details
BioGPS NCI60218389_s_atGM2345727.538781.130Details
BioGPS NCI60218389_s_atGM2493349.406781.130Details
BioGPS NCI60218389_s_atGM97420.451781.130Details
BioGPS NCI60218389_s_atHCC2998887.776781.130Details
BioGPS NCI60218389_s_atHCT116694.382781.130Details
BioGPS NCI60218389_s_atHCT151374.881781.130Details
BioGPS NCI60218389_s_atHEK 293 T-rex418.270781.130Details
BioGPS NCI60218389_s_atHEK 293T1386.854781.130Details
BioGPS NCI60218389_s_atHEK293759.716781.130Details
BioGPS NCI60218389_s_atHELA391.785781.130Details
BioGPS NCI60218389_s_atHEPG2341.749781.130Details
BioGPS NCI60218389_s_atHL60555.675781.130Details
BioGPS NCI60218389_s_atHOP621105.972781.130Details
BioGPS NCI60218389_s_atHOP92616.652781.130Details
BioGPS NCI60218389_s_atHS578T778.917781.130Details
BioGPS NCI60218389_s_atHSG930.017781.130Details
BioGPS NCI60218389_s_atHT1080367.322781.130Details
BioGPS NCI60218389_s_atHT29544.474781.130Details
BioGPS NCI60218389_s_atIGROV1646.626781.130Details
BioGPS NCI60218389_s_atIOSE80922.130781.130Details
BioGPS NCI60218389_s_atJURKAT374.652781.130Details
BioGPS NCI60218389_s_atK562432.978781.130Details
BioGPS NCI60218389_s_atKM12763.013781.130Details
BioGPS NCI60218389_s_atLN18399.394781.130Details
BioGPS NCI60218389_s_atLNCAP696.922781.130Details
BioGPS NCI60218389_s_atLOX IMVI1064.285781.130Details
BioGPS NCI60218389_s_atM14618.314781.130Details
BioGPS NCI60218389_s_atMALME 3M697.861781.130Details
BioGPS NCI60218389_s_atMCF72072.098781.130Details
BioGPS NCI60218389_s_atMD MB231681.783781.130Details
BioGPS NCI60218389_s_atMDA MB4352403.652781.130Details
BioGPS NCI60218389_s_atMOLT41007.439781.130Details
BioGPS NCI60218389_s_atNCI 460687.690781.130Details
BioGPS NCI60218389_s_atNCI H226729.806781.130Details
BioGPS NCI60218389_s_atNCI H23869.509781.130Details
BioGPS NCI60218389_s_atNCI H322M961.012781.130Details
BioGPS NCI60218389_s_atNCVADR RES361.775781.130Details
BioGPS NCI60218389_s_atOVCAR3561.029781.130Details
BioGPS NCI60218389_s_atOVCAR41058.446781.130Details
BioGPS NCI60218389_s_atOVCAR5827.620781.130Details
BioGPS NCI60218389_s_atOVCAR8477.490781.130Details
BioGPS NCI60218389_s_atPANC11037.022781.130Details
BioGPS NCI60218389_s_atRL7612.043781.130Details
BioGPS NCI60218389_s_atRPMI 82261039.541781.130Details
BioGPS NCI60218389_s_atRS11846723.233781.130Details
BioGPS NCI60218389_s_atRXF393785.966781.130Details
BioGPS NCI60218389_s_atSAOS21058.446781.130Details
BioGPS NCI60218389_s_atSF268675.790781.130Details
BioGPS NCI60218389_s_atSF295670.213781.130Details
BioGPS NCI60218389_s_atSF539823.453781.130Details
BioGPS NCI60218389_s_atSHSYSY+RA1231.251781.130Details
BioGPS NCI60218389_s_atSHSYSY-RA1279.306781.130Details
BioGPS NCI60218389_s_atSKMEL2835.570781.130Details
BioGPS NCI60218389_s_atSKMEL28678.872781.130Details
BioGPS NCI60218389_s_atSKMEL51360.288781.130Details
BioGPS NCI60218389_s_atSKOV3416.412781.130Details
BioGPS NCI60218389_s_atSN12C954.363781.130Details
BioGPS NCI60218389_s_atSNB191055.019781.130Details
BioGPS NCI60218389_s_atSNB75467.249781.130Details
BioGPS NCI60218389_s_atSR886.053781.130Details
BioGPS NCI60218389_s_atSW620676.121781.130Details
BioGPS NCI60218389_s_atT24556.268781.130Details
BioGPS NCI60218389_s_atT3M4740.002781.130Details
BioGPS NCI60218389_s_atTK10675.140781.130Details
BioGPS NCI60218389_s_atU118271.175781.130Details
BioGPS NCI60218389_s_atU138514.948781.130Details
BioGPS NCI60218389_s_atU20S770.973781.130Details
BioGPS NCI60218389_s_atU251884.783781.130Details
BioGPS NCI60218389_s_atU87242.333781.130Details
BioGPS NCI60218389_s_atUACC257781.836781.130Details
BioGPS NCI60218389_s_atUACC62511.289781.130Details
BioGPS NCI60218389_s_atUO31697.929781.130Details
BioGPS NCI60218389_s_atZR75_11110.754781.130Details
BioGPS NCI60218389_s_atastrocytes705.691781.130Details
BioGPS NCI60218389_s_athuh-7564.904781.130Details