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Gene ID: 27301 | APEX2 Antibody Resource


APEX2 Antibody Resource
Gene Full Name: 
APEX nuclease (apurinic/apyrimidinic endonuclease) 2
Uniprot: 
Q9UBZ4
Protein Name: 
DNA-(apurinic or apyrimidinic site) lyase 2
Nucleotide: 
NM_014481
Alias: 
APE2;XTH2;APEXL2;
Ensembl: 
Location: 
Xp11.21
HPRD: 
06442
NCBI Gene: 
27301
MIM: 
300773

Summary: 
Apurinic/apyrimidinic (AP) sites occur frequently in DNA molecules by spontaneous hydrolysis, by DNA damaging agents or by DNA glycosylases that remove specific abnormal bases. AP sites are pre-mutagenic lesions that can prevent normal DNA replication so the cell contains systems to identify and repair such sites. Class II AP endonucleases cleave the phosphodiester backbone 5' to the AP site. This gene encodes a protein shown to have a weak class II AP endonuclease activity. Most of the encoded protein is located in the nucleus but some is also present in mitochondria. This protein may play an important role in both nuclear and mitochondrial base excision repair. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2012]
Function: 
Function as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents. Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Displays also double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities. Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially. Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents. In the nucleus functions in the PCNA-dependent BER pathway. Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes. Required for proper cell cycle progression during proliferation of peripheral lymphocytes.
Subcellular location: 
Nucleus. Cytoplasm. Mitochondrion Probable. Note: Together with PCNA, is redistributed in discrete nuclear foci in presence of oxidative DNA damaging agents.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB05572 APEX2 antibody - center region (OAAB05572) Human WB, FC, IHC, ELISA 400ul $289 Details
Polyclonal Antibody ARP65215_P050 APEX2 Antibody (ARP65215_P050) Polyclonal Bovine, Horse, Human Not tested 50 ug $125 Details
Polyclonal Antibody ARP65216_P050 APEX2 Antibody (ARP65216_P050) Polyclonal Horse, Human, Pig, Rabbit Not tested 50 ug $125 Details

Show all APEX2 antibodies


Product Images
APEX2 antibody - center region (OAAB05572) in human lung carcinoma cells using Immunohistochemistry

Sample Type: human lung carcinoma

APEX2 antibody - center region (OAAB05572) in MCF-7 cells using Western Blot

Sample Type: MCF-7

APEX2 antibody - center region (OAAB05572) in MCF-7 cells using Flow Cytometry

Sample Type: MCF-7


APEX2 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP65216 African elephant APEX2 antibody; Loxodonta africana APEX2 antibody G3TKI8 86.0%
ARP65215 Bovine APEX2 antibody; Bos taurus APEX2 antibody F1MSK4 85.0%
ARP65215 Bovine APEX2 antibody; Bos taurus APEX2 antibody Q5E9N9 85.0%
ARP65216 Cat APEX2 antibody; Felis catus APEX2 antibody M3X3R1 79.0%
ARP65215 Chimpanzee APEX2 antibody; Pan troglodytes APEX2 antibody H2QYP0 100.0%
ARP65215 Chimpanzee APEX2 antibody; Pan troglodytes APEX2 antibody K6ZDW9 100.0%
ARP65216 Chimpanzee APEX2 antibody; Pan troglodytes APEX2 antibody H2QYP0 93.0%
ARP65216 Chimpanzee APEX2 antibody; Pan troglodytes APEX2 antibody K6ZDW9 93.0%
ARP65215 European domestic ferret APEX2 antibody; Mustela putorius furo APEX2 antibody M3XW11 79.0%
ARP65216 Giant panda APEX2 antibody; Ailuropoda melanoleuca APEX2 antibody D2I7U1 79.0%
ARP65215 Horse APEX2 antibody; Equus caballus APEX2 antibody H9H023 93.0%
ARP65216 Horse APEX2 antibody; Equus caballus APEX2 antibody H9H023 86.0%
ARP65215 Human APEX2 antibody; Homo sapiens APEX2 antibody B7ZA71 100.0%
ARP65216 Human APEX2 antibody; Homo sapiens APEX2 antibody B7ZA71 100.0%
ARP65215 Human APEX2 antibody; Homo sapiens APEX2 antibody E5KN95 100.0%
ARP65216 Human APEX2 antibody; Homo sapiens APEX2 antibody E5KN95 100.0%
ARP65215 Human APEX2 antibody; Homo sapiens APEX2 antibody Q9UBZ4 100.0%
ARP65216 Human APEX2 antibody; Homo sapiens APEX2 antibody Q9UBZ4 100.0%
ARP65216 Pig APEX2 antibody; Sus scrofa APEX2 antibody F1RUD3 85.0%
ARP65216 Rabbit APEX2 antibody; Oryctolagus cuniculus APEX2 antibody G1TSK9 93.0%
ARP65215 Rhesus macaque APEX2 antibody; Macaca mulatta APEX2 antibody F6VBU4 86.0%
ARP65216 Rhesus macaque APEX2 antibody; Macaca mulatta APEX2 antibody F6VBU4 79.0%
ARP65215 Small-eared galago APEX2 antibody; Otolemur garnettii APEX2 antibody H0WX29 86.0%
ARP65215 Sumatran orangutan APEX2 antibody; Pongo abelii APEX2 antibody H2PVS2 100.0%
ARP65216 Sumatran orangutan APEX2 antibody; Pongo abelii APEX2 antibody H2PVS2 93.0%
ARP65215 Thirteen-lined ground squirrel APEX2 antibody; Spermophilus tridecemlineatus APEX2 antibody I3NB59 79.0%
ARP65216 White-tufted-ear marmoset APEX2 antibody; Callithrix jacchus APEX2 antibody F6U997 92.0%
ARP65216 White-tufted-ear marmoset APEX2 antibody; Callithrix jacchus APEX2 antibody F6XGV2 92.0%
ARP65215 White-tufted-ear marmoset APEX2 antibody; Callithrix jacchus APEX2 antibody F6U997 86.0%
ARP65215 White-tufted-ear marmoset APEX2 antibody; Callithrix jacchus APEX2 antibody F6XGV2 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas204408_at721_B_lymphoblasts64.75013.380Details
BioGPS Gene Atlas204408_atAdipocyte9.80013.380Details
BioGPS Gene Atlas204408_atAdrenalCortex12.75013.380Details
BioGPS Gene Atlas204408_atAdrenalgland9.00013.380Details
BioGPS Gene Atlas204408_atAmygdala10.15013.380Details
BioGPS Gene Atlas204408_atAppendix10.20013.380Details
BioGPS Gene Atlas204408_atAtrioventricularNode8.20013.380Details
BioGPS Gene Atlas204408_atBDCA4+_DentriticCells9.80013.380Details
BioGPS Gene Atlas204408_atBonemarrow15.30013.380Details
BioGPS Gene Atlas204408_atBronchialEpithelialCells14.90013.380Details
BioGPS Gene Atlas204408_atCD105+_Endothelial10.35013.380Details
BioGPS Gene Atlas204408_atCD14+_Monocytes17.40013.380Details
BioGPS Gene Atlas204408_atCD19+_BCells(neg._sel.)20.90013.380Details
BioGPS Gene Atlas204408_atCD33+_Myeloid11.40013.380Details
BioGPS Gene Atlas204408_atCD34+11.30013.380Details
BioGPS Gene Atlas204408_atCD4+_Tcells14.05013.380Details
BioGPS Gene Atlas204408_atCD56+_NKCells10.85013.380Details
BioGPS Gene Atlas204408_atCD71+_EarlyErythroid29.80013.380Details
BioGPS Gene Atlas204408_atCD8+_Tcells8.50013.380Details
BioGPS Gene Atlas204408_atCardiacMyocytes15.10013.380Details
BioGPS Gene Atlas204408_atCaudatenucleus9.00013.380Details
BioGPS Gene Atlas204408_atCerebellum9.85013.380Details
BioGPS Gene Atlas204408_atCerebellumPeduncles13.75013.380Details
BioGPS Gene Atlas204408_atCiliaryGanglion7.00013.380Details
BioGPS Gene Atlas204408_atCingulateCortex11.70013.380Details
BioGPS Gene Atlas204408_atColorectaladenocarcinoma92.80013.380Details
BioGPS Gene Atlas204408_atDorsalRootGanglion7.65013.380Details
BioGPS Gene Atlas204408_atFetalThyroid9.95013.380Details
BioGPS Gene Atlas204408_atFetalbrain8.85013.380Details
BioGPS Gene Atlas204408_atFetalliver10.25013.380Details
BioGPS Gene Atlas204408_atFetallung10.90013.380Details
BioGPS Gene Atlas204408_atGlobusPallidus7.35013.380Details
BioGPS Gene Atlas204408_atHeart21.50013.380Details
BioGPS Gene Atlas204408_atHypothalamus10.80013.380Details
BioGPS Gene Atlas204408_atKidney8.85013.380Details
BioGPS Gene Atlas204408_atLeukemia_chronicMyelogenousK-56216.30013.380Details
BioGPS Gene Atlas204408_atLeukemia_promyelocytic-HL-6012.85013.380Details
BioGPS Gene Atlas204408_atLeukemialymphoblastic(MOLT-4)14.45013.380Details
BioGPS Gene Atlas204408_atLiver24.80013.380Details
BioGPS Gene Atlas204408_atLung22.15013.380Details
BioGPS Gene Atlas204408_atLymphnode8.95013.380Details
BioGPS Gene Atlas204408_atLymphoma_burkitts(Daudi)26.05013.380Details
BioGPS Gene Atlas204408_atLymphoma_burkitts(Raji)15.20013.380Details
BioGPS Gene Atlas204408_atMedullaOblongata8.85013.380Details
BioGPS Gene Atlas204408_atOccipitalLobe8.70013.380Details
BioGPS Gene Atlas204408_atOlfactoryBulb7.30013.380Details
BioGPS Gene Atlas204408_atOvary6.85013.380Details
BioGPS Gene Atlas204408_atPancreas8.35013.380Details
BioGPS Gene Atlas204408_atPancreaticIslet13.90013.380Details
BioGPS Gene Atlas204408_atParietalLobe10.90013.380Details
BioGPS Gene Atlas204408_atPituitary12.45013.380Details
BioGPS Gene Atlas204408_atPlacenta12.50013.380Details
BioGPS Gene Atlas204408_atPons10.00013.380Details
BioGPS Gene Atlas204408_atPrefrontalCortex11.70013.380Details
BioGPS Gene Atlas204408_atProstate14.55013.380Details
BioGPS Gene Atlas204408_atSalivarygland7.85013.380Details
BioGPS Gene Atlas204408_atSkeletalMuscle19.85013.380Details
BioGPS Gene Atlas204408_atSkin7.55013.380Details
BioGPS Gene Atlas204408_atSmoothMuscle11.15013.380Details
BioGPS Gene Atlas204408_atSpinalcord10.50013.380Details
BioGPS Gene Atlas204408_atSubthalamicNucleus8.75013.380Details
BioGPS Gene Atlas204408_atSuperiorCervicalGanglion12.65013.380Details
BioGPS Gene Atlas204408_atTemporalLobe11.25013.380Details
BioGPS Gene Atlas204408_atTestis8.55013.380Details
BioGPS Gene Atlas204408_atTestisGermCell8.25013.380Details
BioGPS Gene Atlas204408_atTestisIntersitial8.15013.380Details
BioGPS Gene Atlas204408_atTestisLeydigCell9.70013.380Details
BioGPS Gene Atlas204408_atTestisSeminiferousTubule8.15013.380Details
BioGPS Gene Atlas204408_atThalamus9.95013.380Details
BioGPS Gene Atlas204408_atThymus11.90013.380Details
BioGPS Gene Atlas204408_atThyroid21.20013.380Details
BioGPS Gene Atlas204408_atTongue10.15013.380Details
BioGPS Gene Atlas204408_atTonsil15.50013.380Details
BioGPS Gene Atlas204408_atTrachea8.25013.380Details
BioGPS Gene Atlas204408_atTrigeminalGanglion10.15013.380Details
BioGPS Gene Atlas204408_atUterus7.60013.380Details
BioGPS Gene Atlas204408_atUterusCorpus10.85013.380Details
BioGPS Gene Atlas204408_atWholeBlood12.85013.380Details
BioGPS Gene Atlas204408_atWholebrain10.15013.380Details
BioGPS Gene Atlas204408_atcolon10.30013.380Details
BioGPS Gene Atlas204408_atpineal_day10.36013.380Details
BioGPS Gene Atlas204408_atpineal_night9.94013.380Details
BioGPS Gene Atlas204408_atretina12.15013.380Details
BioGPS Gene Atlas204408_atsmall_intestine9.40013.380Details
BioGPS NCI60204408_at78682.065136.180Details
BioGPS NCI60204408_atA17256.423136.180Details
BioGPS NCI60204408_atA20498.616136.180Details
BioGPS NCI60204408_atA361129.462136.180Details
BioGPS NCI60204408_atA49890.276136.180Details
BioGPS NCI60204408_atA549177.624136.180Details
BioGPS NCI60204408_atACC3226.284136.180Details
BioGPS NCI60204408_atACHN68.993136.180Details
BioGPS NCI60204408_atALVA31257.322136.180Details
BioGPS NCI60204408_atCAKI178.114136.180Details
BioGPS NCI60204408_atCCRT CEM30.623136.180Details
BioGPS NCI60204408_atCOLO20593.146136.180Details
BioGPS NCI60204408_atDLD1369.293136.180Details
BioGPS NCI60204408_atDU145151.176136.180Details
BioGPS NCI60204408_atEKVX90.459136.180Details
BioGPS NCI60204408_atGM13325.003136.180Details
BioGPS NCI60204408_atGM160034.823136.180Details
BioGPS NCI60204408_atGM231343.069136.180Details
BioGPS NCI60204408_atGM234524.323136.180Details
BioGPS NCI60204408_atGM249328.356136.180Details
BioGPS NCI60204408_atGM9747.769136.180Details
BioGPS NCI60204408_atHCC2998143.589136.180Details
BioGPS NCI60204408_atHCT116201.910136.180Details
BioGPS NCI60204408_atHCT15127.513136.180Details
BioGPS NCI60204408_atHEK 293 T-rex109.885136.180Details
BioGPS NCI60204408_atHEK 293T107.115136.180Details
BioGPS NCI60204408_atHEK29330.926136.180Details
BioGPS NCI60204408_atHELA547.819136.180Details
BioGPS NCI60204408_atHEPG2192.435136.180Details
BioGPS NCI60204408_atHL6085.845136.180Details
BioGPS NCI60204408_atHOP62104.359136.180Details
BioGPS NCI60204408_atHOP92241.129136.180Details
BioGPS NCI60204408_atHS578T92.089136.180Details
BioGPS NCI60204408_atHSG293.575136.180Details
BioGPS NCI60204408_atHT108076.948136.180Details
BioGPS NCI60204408_atHT29122.881136.180Details
BioGPS NCI60204408_atIGROV1122.310136.180Details
BioGPS NCI60204408_atIOSE80138.064136.180Details
BioGPS NCI60204408_atJURKAT185.535136.180Details
BioGPS NCI60204408_atK56275.619136.180Details
BioGPS NCI60204408_atKM12170.899136.180Details
BioGPS NCI60204408_atLN1849.625136.180Details
BioGPS NCI60204408_atLNCAP141.423136.180Details
BioGPS NCI60204408_atLOX IMVI58.346136.180Details
BioGPS NCI60204408_atM14233.775136.180Details
BioGPS NCI60204408_atMALME 3M125.020136.180Details
BioGPS NCI60204408_atMCF7175.900136.180Details
BioGPS NCI60204408_atMD MB231147.800136.180Details
BioGPS NCI60204408_atMDA MB435507.011136.180Details
BioGPS NCI60204408_atMOLT4130.581136.180Details
BioGPS NCI60204408_atNCI 460112.020136.180Details
BioGPS NCI60204408_atNCI H226222.492136.180Details
BioGPS NCI60204408_atNCI H23176.954136.180Details
BioGPS NCI60204408_atNCI H322M140.367136.180Details
BioGPS NCI60204408_atNCVADR RES85.027136.180Details
BioGPS NCI60204408_atOVCAR372.424136.180Details
BioGPS NCI60204408_atOVCAR4267.942136.180Details
BioGPS NCI60204408_atOVCAR5168.725136.180Details
BioGPS NCI60204408_atOVCAR8145.580136.180Details
BioGPS NCI60204408_atPANC1118.517136.180Details
BioGPS NCI60204408_atRL7121.574136.180Details
BioGPS NCI60204408_atRPMI 8226108.837136.180Details
BioGPS NCI60204408_atRS11846129.359136.180Details
BioGPS NCI60204408_atRXF393107.258136.180Details
BioGPS NCI60204408_atSAOS2152.802136.180Details
BioGPS NCI60204408_atSF268116.940136.180Details
BioGPS NCI60204408_atSF295126.603136.180Details
BioGPS NCI60204408_atSF539282.562136.180Details
BioGPS NCI60204408_atSHSYSY+RA88.085136.180Details
BioGPS NCI60204408_atSHSYSY-RA57.969136.180Details
BioGPS NCI60204408_atSKMEL2224.596136.180Details
BioGPS NCI60204408_atSKMEL2859.665136.180Details
BioGPS NCI60204408_atSKMEL588.682136.180Details
BioGPS NCI60204408_atSKOV358.974136.180Details
BioGPS NCI60204408_atSN12C131.285136.180Details
BioGPS NCI60204408_atSNB19114.278136.180Details
BioGPS NCI60204408_atSNB7575.582136.180Details
BioGPS NCI60204408_atSR136.665136.180Details
BioGPS NCI60204408_atSW620482.172136.180Details
BioGPS NCI60204408_atT24240.511136.180Details
BioGPS NCI60204408_atT3M487.941136.180Details
BioGPS NCI60204408_atTK1060.335136.180Details
BioGPS NCI60204408_atU11870.050136.180Details
BioGPS NCI60204408_atU13847.865136.180Details
BioGPS NCI60204408_atU20S345.356136.180Details
BioGPS NCI60204408_atU251223.440136.180Details
BioGPS NCI60204408_atU8777.123136.180Details
BioGPS NCI60204408_atUACC25783.224136.180Details
BioGPS NCI60204408_atUACC6283.823136.180Details
BioGPS NCI60204408_atUO31115.040136.180Details
BioGPS NCI60204408_atZR75_1123.367136.180Details
BioGPS NCI60204408_atastrocytes103.067136.180Details
BioGPS NCI60204408_athuh-7122.123136.180Details