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Gene ID: 160 | AP2A1 Antibody Resource


AP2A1 Antibody Resource
Gene Full Name: 
adaptor-related protein complex 2, alpha 1 subunit
Uniprot: 
O95782
Protein Name: 
AP-2 complex subunit alpha-1
Nucleotide: 
NM_014203
Alias: 
ADTAA;CLAPA1;AP2-ALPHA;
Ensembl: 
ENSG00000196961
Location: 
19q13.33
HPRD: 
03016
NCBI Gene: 
160
MIM: 
601026

Summary: 
This gene encodes the alpha 1 adaptin subunit of the adaptor protein 2 (AP-2) complex found in clathrin coated vesicles. The AP-2 complex is a heterotetramer consisting of two large adaptins (alpha or beta), a medium adaptin (mu), and a small adaptin (sigma). The complex is part of the protein coat on the cytoplasmic face of coated vesicles which links clathrin to receptors in vesicles. Alternative splicing of this gene results in two transcript variants encoding two different isoforms. A third transcript variant has been described, but its full length nature has not been determined. [provided by RefSeq, Jul 2008]
Function: 
Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif .
Subcellular location: 
Cell membrane. Membrane › coated pit; Peripheral membrane protein; Cytoplasmic side. Note: AP-2 appears to be excluded from internalizing CCVs and to disengage from sites of endocytosis seconds before internalization of the nascent CCV .
PTM: 
Phosphoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP59972_P050 AP2A1 antibody - C-terminal region (ARP59972_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody ARP59973_P050 AP2A1 Antibody (ARP59973_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish Not tested 50 ug $125 Details
Polyclonal Antibody OAAB10203 AP2A1 antibody - C - terminal region (OAAB10203) Human WB, IHC 400ul $289 Details

Show all AP2A1 antibodies


Product Images
AP2A1 antibody - C-terminal region (ARP59972_P050) in Human Brain cells using Western Blot

Sample Type: Human Brain

AP2A1 antibody - C - terminal region (OAAB10203) in 293 cells using Western Blot

Sample Type: 293

AP2A1 antibody - C - terminal region (OAAB10203) in Human Cerebellum cells using Immunohistochemistry

Sample Type: Human Cerebellum


AP2A1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59973 Bovine AP2A1 antibody; Bos taurus AP2A1 antibody Q1JPJ7 100.0%
ARP59975 Bovine AP2A1 antibody; Bos taurus AP2A1 antibody Q1JPJ7 93.0%
ARP59973 Cat AP2A1 antibody; Felis catus AP2A1 antibody M3W262 100.0%
ARP59972 Cat AP2A1 antibody; Felis catus AP2A1 antibody M3W262 93.0%
ARP59972 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody H2R0B2 100.0%
ARP59973 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody H2R0B2 100.0%
ARP59972 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7AS24 100.0%
ARP59975 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7AS24 100.0%
ARP59972 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7BVK5 100.0%
ARP59973 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7BVK5 100.0%
ARP59972 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7DCI8 100.0%
ARP59973 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7DCI8 100.0%
ARP59975 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody H2R0B2 93.0%
ARP59975 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7BVK5 93.0%
ARP59975 Chimpanzee AP2A1 antibody; Pan troglodytes AP2A1 antibody K7DCI8 93.0%
ARP59973 Dog AP2A1 antibody; Canis familiaris AP2A1 antibody F1PE67 100.0%
ARP59973 Dog AP2A1 antibody; Canis familiaris AP2A1 antibody J9NWS6 100.0%
ARP59972 Dog AP2A1 antibody; Canis familiaris AP2A1 antibody F1PE67 93.0%
ARP59972 Dog AP2A1 antibody; Canis familiaris AP2A1 antibody J9NWS6 93.0%
ARP59975 Dog AP2A1 antibody; Canis familiaris AP2A1 antibody J9NWS6 93.0%
ARP59973 Duckbill platypus AP2A1 antibody; Ornithorhynchus anatinus AP2A1 antibody K7EHL6 100.0%
ARP59975 Duckbill platypus AP2A1 antibody; Ornithorhynchus anatinus AP2A1 antibody K7EHL6 93.0%
ARP59972 European domestic ferret AP2A1 antibody; Mustela putorius furo AP2A1 antibody M3XTE6 100.0%
ARP59973 European domestic ferret AP2A1 antibody; Mustela putorius furo AP2A1 antibody M3XTE6 100.0%
ARP59972 Giant panda AP2A1 antibody; Ailuropoda melanoleuca AP2A1 antibody G1M5C2 100.0%
ARP59973 Giant panda AP2A1 antibody; Ailuropoda melanoleuca AP2A1 antibody G1M5C2 100.0%
ARP59972 Giant panda AP2A1 antibody; Ailuropoda melanoleuca AP2A1 antibody G1M5B1 100.0%
ARP59973 Giant panda AP2A1 antibody; Ailuropoda melanoleuca AP2A1 antibody G1M5B1 100.0%
ARP59975 Giant panda AP2A1 antibody; Ailuropoda melanoleuca AP2A1 antibody G1M5B1 93.0%
ARP59975 Giant panda AP2A1 antibody; Ailuropoda melanoleuca AP2A1 antibody G1M5C2 93.0%
ARP59973 Guinea pig AP2A1 antibody; Cavia porcellus AP2A1 antibody H0V4P1 100.0%
ARP59972 Guinea pig AP2A1 antibody; Cavia porcellus AP2A1 antibody H0V4P1 86.0%
ARP59972 Horse AP2A1 antibody; Equus caballus AP2A1 antibody F7DCS5 100.0%
ARP59973 Horse AP2A1 antibody; Equus caballus AP2A1 antibody F7DCS5 100.0%
ARP59972 Horse AP2A1 antibody; Equus caballus AP2A1 antibody F7DH20 100.0%
ARP59973 Horse AP2A1 antibody; Equus caballus AP2A1 antibody F7DH20 100.0%
ARP59975 Horse AP2A1 antibody; Equus caballus AP2A1 antibody F7DCS5 93.0%
ARP59975 Horse AP2A1 antibody; Equus caballus AP2A1 antibody F7DH20 93.0%
ARP59972 Human AP2A1 antibody; Homo sapiens AP2A1 antibody O95782-2 100.0%
ARP59973 Human AP2A1 antibody; Homo sapiens AP2A1 antibody O95782-2 100.0%
ARP59972 Human AP2A1 antibody; Homo sapiens AP2A1 antibody O95782 100.0%
ARP59973 Human AP2A1 antibody; Homo sapiens AP2A1 antibody O95782 100.0%
ARP59975 Human AP2A1 antibody; Homo sapiens AP2A1 antibody O95782-2 93.0%
ARP59973 Mouse AP2A1 antibody; Mus musculus AP2A1 antibody P17426-2 100.0%
ARP59973 Mouse AP2A1 antibody; Mus musculus AP2A1 antibody P17426 100.0%
ARP59975 Mouse AP2A1 antibody; Mus musculus AP2A1 antibody P17426-2 93.0%
ARP59972 Mouse AP2A1 antibody; Mus musculus AP2A1 antibody P17426-2 86.0%
ARP59972 Mouse AP2A1 antibody; Mus musculus AP2A1 antibody P17426 86.0%
ARP59972 Northern white-cheeked gibbon AP2A1 antibody; Nomascus leucogenys AP2A1 antibody M3ZB39 100.0%
ARP59972 Northern white-cheeked gibbon AP2A1 antibody; Nomascus leucogenys AP2A1 antibody G1QZT6 100.0%
ARP59973 Northern white-cheeked gibbon AP2A1 antibody; Nomascus leucogenys AP2A1 antibody M3ZB39 100.0%
ARP59973 Northern white-cheeked gibbon AP2A1 antibody; Nomascus leucogenys AP2A1 antibody G1QZT6 100.0%
ARP59975 Northern white-cheeked gibbon AP2A1 antibody; Nomascus leucogenys AP2A1 antibody M3ZB39 93.0%
ARP59975 Northern white-cheeked gibbon AP2A1 antibody; Nomascus leucogenys AP2A1 antibody G1QZT6 93.0%
ARP59973 Pig AP2A1 antibody; Sus scrofa AP2A1 antibody F1RH60 100.0%
ARP59973 Pig AP2A1 antibody; Sus scrofa AP2A1 antibody I3LK24 100.0%
ARP59972 Pig AP2A1 antibody; Sus scrofa AP2A1 antibody F1RH60 93.0%
ARP59972 Pig AP2A1 antibody; Sus scrofa AP2A1 antibody I3LK24 93.0%
ARP59975 Pig AP2A1 antibody; Sus scrofa AP2A1 antibody I3LK24 93.0%
ARP59973 Rabbit AP2A1 antibody; Oryctolagus cuniculus AP2A1 antibody G1U8F0 100.0%
ARP59975 Rabbit AP2A1 antibody; Oryctolagus cuniculus AP2A1 antibody G1U8F0 93.0%
ARP59972 Rabbit AP2A1 antibody; Oryctolagus cuniculus AP2A1 antibody G1U8F0 86.0%
ARP59973 Rat AP2A1 antibody; Rattus norvegicus AP2A1 antibody D3ZUY8 100.0%
ARP59972 Rat AP2A1 antibody; Rattus norvegicus AP2A1 antibody D3ZUY8 86.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody F6PL31 100.0%
ARP59973 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody F6PL31 100.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody F6PL38 100.0%
ARP59973 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody F6PL38 100.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK7 100.0%
ARP59975 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK7 100.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK8 100.0%
ARP59973 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK8 100.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK9 100.0%
ARP59973 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK9 100.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQL0 100.0%
ARP59973 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQL0 100.0%
ARP59972 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody I0FPJ3 100.0%
ARP59975 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody I0FPJ3 100.0%
ARP59975 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody F6PL31 93.0%
ARP59975 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody F6PL38 93.0%
ARP59975 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQK9 93.0%
ARP59975 Rhesus macaque AP2A1 antibody; Macaca mulatta AP2A1 antibody H9FQL0 93.0%
ARP59972 Small-eared galago AP2A1 antibody; Otolemur garnettii AP2A1 antibody H0XFI2 100.0%
ARP59973 Small-eared galago AP2A1 antibody; Otolemur garnettii AP2A1 antibody H0XFI2 100.0%
ARP59975 Small-eared galago AP2A1 antibody; Otolemur garnettii AP2A1 antibody H0XFI2 93.0%
ARP59973 Sumatran orangutan AP2A1 antibody; Pongo abelii AP2A1 antibody H2NZP4 100.0%
ARP59975 Sumatran orangutan AP2A1 antibody; Pongo abelii AP2A1 antibody H2NZP4 93.0%
ARP59973 Tasmanian devil AP2A1 antibody; Sarcophilus harrisii AP2A1 antibody G3VAH3 100.0%
ARP59975 Tasmanian devil AP2A1 antibody; Sarcophilus harrisii AP2A1 antibody G3VAH3 93.0%
ARP59972 Thirteen-lined ground squirrel AP2A1 antibody; Spermophilus tridecemlineatus AP2A1 antibody I3MJR2 93.0%
ARP59973 Three-spined stickleback AP2A1 antibody; Gasterosteus aculeatus AP2A1 antibody G3NM96 100.0%
ARP59975 Three-spined stickleback AP2A1 antibody; Gasterosteus aculeatus AP2A1 antibody G3NM96 93.0%
ARP59973 Western clawed frog AP2A1 antibody; Xenopus tropicalis AP2A1 antibody F7DA66 100.0%
ARP59973 Western clawed frog AP2A1 antibody; Xenopus tropicalis AP2A1 antibody Q0IHS1 100.0%
ARP59973 Western clawed frog AP2A1 antibody; Xenopus tropicalis AP2A1 antibody L7N340 100.0%
ARP59975 Western clawed frog AP2A1 antibody; Xenopus tropicalis AP2A1 antibody L7N340 93.0%
ARP59975 Western clawed frog AP2A1 antibody; Xenopus tropicalis AP2A1 antibody F7DA66 93.0%
ARP59975 Western clawed frog AP2A1 antibody; Xenopus tropicalis AP2A1 antibody Q0IHS1 93.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F6PJU6 100.0%
ARP59973 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F6PJU6 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F6U3L3 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F6U4P1 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3BTA7 100.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3BTA7 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3CAN6 100.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3CAN6 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7GVA1 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3DMX5 100.0%
ARP59973 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7GVA1 100.0%
ARP59973 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3DMX5 100.0%
ARP64666 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7ID43 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3EAR0 100.0%
ARP64667 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7ID43 100.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3EAR0 100.0%
ARP64666 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7IFK2 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3F4B7 100.0%
ARP64667 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7IFK2 100.0%
ARP59973 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3F4B7 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3FHN3 100.0%
ARP59973 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3FHN3 100.0%
ARP59972 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3FYA6 100.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3FYA6 100.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F6PJU6 93.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody F7GVA1 93.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3F4B7 93.0%
ARP59975 White-tufted-ear marmoset AP2A1 antibody; Callithrix jacchus AP2A1 antibody U3FHN3 93.0%

Tissue & Cell Line Gene Expression Data