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Gene ID: 196527 | Ano6 Antibody Resource


Ano6 Antibody Resource
Gene Full Name: 
anoctamin 6
Uniprot: 
Q4KMQ2
Protein Name: 
anoctamin-6
Nucleotide: 
NM_001142679
Alias: 
SCTS;BDPLT7;TMEM16F;
Ensembl: 
ENSG00000177119
Location: 
12q12
HPRD: 
18746
NCBI Gene: 
196527
MIM: 
608663

Summary: 
This gene encodes a multi-pass transmembrane protein that belongs to the anoctamin family. This protein is an essential component for the calcium-dependent exposure of phosphatidylserine on the cell surface. The scrambling of phospholipid occurs in various biological systems, such as when blood platelets are activated, they expose phosphatidylserine to trigger the clotting system. Mutations in this gene are associated with Scott syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.[provided by RefSeq, Mar 2011]
Function: 
Small-conductance calcium-activated nonselective cation (SCAN) channel which acts as a regulator of phospholipid scrambling in platelets and osteoblasts. Phospholipid scrambling results in surface exposure of phosphatidylserine which in platelets is essential to trigger the clotting system whereas in osteoblasts is essential for the deposition of hydroxyapatite during bone mineralization. Can generate outwardly rectifying chloride channel currents in airway epithelial cells and Jurkat T lymphocytes.
Subcellular location: 
Cell membrane; Multi-pass membrane protein. Note: Shows an intracellular localization according to .
PTM: 
Glycoprotein;
Disease: 
Scott syndrome (SCTS) [MIM:262890]: A mild bleeding disorder due to impaired surface exposure of procoagulant phosphatidylserine (PS) on platelets and other blood cells, following activation with Ca(2+)-elevating agents. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP44761_P050 ANO6 antibody -C-terminal region (ARP44761_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody ARP44759_P050 Ano6 antibody - middle region (ARP44759_P050) Polyclonal Guinea pig, Human, Mouse, Pig, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB15620 ANO6 antibody - N - terminal region (OAAB15620) Human WB 400ul $289 Details

Show all Ano6 antibodies


Product Images
Ano6 antibody - middle region (ARP44759_P050) in Mouse Liver cells using Western Blot

Sample Type: Mouse Liver

ANO6 antibody -C-terminal region (ARP44761_P050) in Human OVCAR-3 cells using Western Blot

Sample Type: Human OVCAR-3

ANO6 antibody - N - terminal region (OAAB15620) in U251 cells using Western Blot

Sample Type: U251


Ano6 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP44761 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3T4L5 93.0%
ARP44761 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3TVE6 93.0%
ARP44761 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3UBD7 93.0%
ARP44761 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3ULA8 93.0%
ARP44759 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3T4L5 86.0%
ARP44759 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3TVE6 86.0%
ARP44759 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3UBD7 86.0%
ARP44759 African elephant Ano6 antibody; Loxodonta africana Ano6 antibody G3ULA8 86.0%
ARP44761 Bovine Ano6 antibody; Bos taurus Ano6 antibody F1MFY7 100.0%
ARP44761 Cat Ano6 antibody; Felis catus Ano6 antibody M3WHP6 100.0%
ARP44759 Cat Ano6 antibody; Felis catus Ano6 antibody M3WHP6 93.0%
ARP44759 Chimpanzee Ano6 antibody; Pan troglodytes Ano6 antibody H2Q5R7 100.0%
ARP44761 Chimpanzee Ano6 antibody; Pan troglodytes Ano6 antibody H2Q5R7 100.0%
ARP44759 Chimpanzee Ano6 antibody; Pan troglodytes Ano6 antibody K6ZKX5 100.0%
ARP44761 Chimpanzee Ano6 antibody; Pan troglodytes Ano6 antibody K6ZKX5 100.0%
ARP44761 Chinese softshell turtle Ano6 antibody; Pelodiscus sinensis Ano6 antibody K7FLD8 100.0%
ARP44761 Dog Ano6 antibody; Canis familiaris Ano6 antibody F1PQ46 93.0%
ARP44761 Dog Ano6 antibody; Canis familiaris Ano6 antibody J9NZU1 93.0%
ARP44761 European domestic ferret Ano6 antibody; Mustela putorius furo Ano6 antibody M3XMS2 79.0%
ARP44761 Giant panda Ano6 antibody; Ailuropoda melanoleuca Ano6 antibody G1MBD8 79.0%
ARP44761 Giant panda Ano6 antibody; Ailuropoda melanoleuca Ano6 antibody G1MBE2 79.0%
ARP44761 Green anole Ano6 antibody; Anolis carolinensis Ano6 antibody G1KAT6 85.0%
ARP44761 Horse Ano6 antibody; Equus caballus Ano6 antibody F6SVE8 93.0%
ARP44761 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2-4 100.0%
ARP44759 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2 100.0%
ARP44761 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2 100.0%
ARP44759 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2-2 100.0%
ARP44761 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2-2 100.0%
ARP44759 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2-3 100.0%
ARP44761 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2-3 100.0%
ARP44759 Human Ano6 antibody; Homo sapiens Ano6 antibody Q4KMQ2-4 100.0%
ARP44761 Mouse Ano6 antibody; Mus musculus Ano6 antibody Q6P9J9-2 93.0%
ARP44761 Mouse Ano6 antibody; Mus musculus Ano6 antibody Q6P9J9 93.0%
ARP44759 Mouse Ano6 antibody; Mus musculus Ano6 antibody Q6P9J9-2 92.0%
ARP44759 Mouse Ano6 antibody; Mus musculus Ano6 antibody Q6P9J9 92.0%
ARP44759 Northern white-cheeked gibbon Ano6 antibody; Nomascus leucogenys Ano6 antibody G1S8D4 100.0%
ARP44761 Northern white-cheeked gibbon Ano6 antibody; Nomascus leucogenys Ano6 antibody G1S8D4 100.0%
ARP44759 Pig Ano6 antibody; Sus scrofa Ano6 antibody F1SGY1 93.0%
ARP44761 Pig Ano6 antibody; Sus scrofa Ano6 antibody F1SGY1 93.0%
ARP44761 Rabbit Ano6 antibody; Oryctolagus cuniculus Ano6 antibody G1SCS8 100.0%
ARP44759 Rat Ano6 antibody; Rattus norvegicus Ano6 antibody F1M5Z5 92.0%
ARP44759 Rhesus macaque Ano6 antibody; Macaca mulatta Ano6 antibody F7GVV8 100.0%
ARP44761 Rhesus macaque Ano6 antibody; Macaca mulatta Ano6 antibody F7GVV8 100.0%
ARP44759 Rhesus macaque Ano6 antibody; Macaca mulatta Ano6 antibody F7HN51 100.0%
ARP44761 Rhesus macaque Ano6 antibody; Macaca mulatta Ano6 antibody F7HN51 100.0%
ARP44759 Rhesus macaque Ano6 antibody; Macaca mulatta Ano6 antibody I0FPS1 100.0%
ARP44761 Rhesus macaque Ano6 antibody; Macaca mulatta Ano6 antibody I0FPS1 100.0%
ARP44761 Small-eared galago Ano6 antibody; Otolemur garnettii Ano6 antibody H0XDL6 100.0%
ARP44759 Small-eared galago Ano6 antibody; Otolemur garnettii Ano6 antibody H0XDL6 93.0%
ARP44759 Sumatran orangutan Ano6 antibody; Pongo abelii Ano6 antibody H2NH13 100.0%
ARP44761 Sumatran orangutan Ano6 antibody; Pongo abelii Ano6 antibody H2NH13 100.0%
ARP44759 Sumatran orangutan Ano6 antibody; Pongo abelii Ano6 antibody K7ETL5 100.0%
ARP44761 Sumatran orangutan Ano6 antibody; Pongo abelii Ano6 antibody K7ETL5 100.0%
ARP44761 Thirteen-lined ground squirrel Ano6 antibody; Spermophilus tridecemlineatus Ano6 antibody I3N1J6 93.0%
ARP44759 Thirteen-lined ground squirrel Ano6 antibody; Spermophilus tridecemlineatus Ano6 antibody I3N1J6 79.0%
ARP44761 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody U3CR28 100.0%
ARP44761 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody F7GEE6 100.0%
ARP44761 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody U3DY17 100.0%
ARP44761 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody F7GEJ1 100.0%
ARP44761 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody F7GF05 100.0%
ARP44759 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody U3CR28 91.0%
ARP44759 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody F7GEE6 91.0%
ARP44759 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody U3DY17 91.0%
ARP44759 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody F7GEJ1 91.0%
ARP44759 White-tufted-ear marmoset Ano6 antibody; Callithrix jacchus Ano6 antibody F7GF05 91.0%

Tissue & Cell Line Gene Expression Data