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Gene ID: 283 | ANG Antibody Resource


ANG Antibody Resource
Gene Full Name: 
angiogenin, ribonuclease, RNase A family, 5
Uniprot: 
P03950
Protein Name: 
angiogenin
Nucleotide: 
NM_001145
Alias: 
ALS9;HEL168;RNASE4;RNASE5;
Ensembl: 
ENSG00000214274
Location: 
14q11.1-q11.2
HPRD: 
00105
NCBI Gene: 
283
MIM: 
105850

Summary: 
The protein encoded by this gene is an exceedingly potent mediator of new blood vessel formation. It hydrolyzes cellular tRNAs resulting in decreased protein synthesis and is similar to pancreatic ribonuclease. Alternative splicing results in two transcript variants encoding the same protein. This gene and the gene that encodes ribonuclease, RNase A family, 4 share promoters and 5' exons. Each gene splices to a unique downstream exon that contains its complete coding region. [provided by RefSeq, Jul 2008]
Function: 
Binds to actin on the surface of endothelial cells; once bound, angiogenin is endocytosed and translocated to the nucleus. Stimulates ribosomal RNA synthesis including that containing the initiation site sequences of 45S rRNA. Cleaves tRNA within anticodon loops to produce tRNA-derived stress-induced fragments (tiRNAs) which inhibit protein synthesis and triggers the assembly of stress granules (SGs). Angiogenin induces vascularization of normal and malignant tissues. Angiogenic activity is regulated by interaction with RNH1 in vivo.
Subcellular location: 
Secreted › extracellular space › extracellular matrix › basement membrane. Nucleus › nucleolus. Note: Rapidly endocytosed by target cells and translocated to the nucleus where it accumulates in the nucleolus and binds to DNA.
PTM: 
Disulfide bond;
Disease: 
Amyotrophic lateral sclerosis 9 (ALS9) [MIM:611895]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Monoclonal Antibody OASA00944 ANG Antibody (OASA00944) Human IHC-AFF, ELISA, IHC-FFPE 0.15mg $900 Details
Protein Lysate APL10392 ANG Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
Protein Lysate APL10393 ANG Protein Lysate (GST tagged) (Expressed in bacteria) (200ug) 200ug $219 Details
DNA/cDNA/RNA ANA10392 ANG (Human) cDNA (1ug) 1ug $189 Details
DNA/cDNA/RNA ANA10393 ANG (Human) cDNA (1ug) 1ug $189 Details
Polyclonal Antibody OAAB00680 ANG antibody - center region (OAAB00680) Human WB, ELISA 400ul $289 Details
Polyclonal Antibody ARP41921_P050 ANG Antibody (ARP41921_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody ARP48092_P050 ANG Antibody (ARP48092_P050) Polyclonal Bovine, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP48093_P050 ANG Antibody (ARP48093_P050) Polyclonal Bovine, Horse, Human, Mouse, Pig Not tested 50 ug $125 Details

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Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP48092 Angolan talapoin ANG antibody; Miopithecus talapoin ANG antibody Q8WN65 100.0%
ARP48093 Angolan talapoin ANG antibody; Miopithecus talapoin ANG antibody Q8WN65 86.0%
ARP48092 Black snub-nosed monkey ANG antibody; Pygathrix bieti ANG antibody Q861Y2 93.0%
ARP48093 Black snub-nosed monkey ANG antibody; Pygathrix bieti ANG antibody Q861Y2 93.0%
ARP41921 Black snub-nosed monkey ANG antibody; Pygathrix bieti ANG antibody Q861Y2 85.0%
ARP41921 Bornean orangutan ANG antibody; Pongo pygmaeus ANG antibody Q8WN67 100.0%
ARP48092 Bornean orangutan ANG antibody; Pongo pygmaeus ANG antibody Q8WN67 100.0%
ARP48093 Bornean orangutan ANG antibody; Pongo pygmaeus ANG antibody Q8WN67 93.0%
ARP48092 Bovine ANG antibody; Bos taurus ANG antibody Q2NKV1 83.0%
ARP48093 Cat ANG antibody; Felis catus ANG antibody M3XDL8 93.0%
ARP48092 Cat ANG antibody; Felis catus ANG antibody M3XDL8 79.0%
ARP41921 Chimpanzee ANG antibody; Pan troglodytes ANG antibody Q8WME8 100.0%
ARP48092 Chimpanzee ANG antibody; Pan troglodytes ANG antibody Q8WME8 100.0%
ARP48093 Chimpanzee ANG antibody; Pan troglodytes ANG antibody Q8WME8 100.0%
ARP48092 Common squirrel monkey ANG antibody; Saimiri sciureus ANG antibody Q8WN60 93.0%
ARP48093 Common squirrel monkey ANG antibody; Saimiri sciureus ANG antibody Q8WN60 93.0%
ARP48092 Cotton-top tamarin ANG antibody; Saguinus oedipus ANG antibody Q8WN62 93.0%
ARP48093 Cotton-top tamarin ANG antibody; Saguinus oedipus ANG antibody Q8WN62 93.0%
ARP48092 Francois's leaf monkey ANG antibody; Trachypithecus francoisi ANG antibody Q861Y4 93.0%
ARP48093 Francois's leaf monkey ANG antibody; Trachypithecus francoisi ANG antibody Q861Y4 93.0%
ARP41921 Francois's leaf monkey ANG antibody; Trachypithecus francoisi ANG antibody Q861Y4 92.0%
ARP48093 Giant panda ANG antibody; Ailuropoda melanoleuca ANG antibody G1MK28 79.0%
ARP48092 Golden snub-nosed monkey ANG antibody; Pygathrix roxellana ANG antibody Q861Y3 93.0%
ARP48093 Golden snub-nosed monkey ANG antibody; Pygathrix roxellana ANG antibody Q861Y3 93.0%
ARP41921 Golden snub-nosed monkey ANG antibody; Pygathrix roxellana ANG antibody Q861Y3 85.0%
ARP48092 Gray short-tailed opossum ANG antibody; Monodelphis domestica ANG antibody F6QUQ6 85.0%
ARP48093 Green monkey ANG antibody; Chlorocebus aethiops ANG antibody Q8WN66 93.0%
ARP48092 Green monkey ANG antibody; Chlorocebus aethiops ANG antibody Q8WN66 93.0%
ARP41921 Green monkey ANG antibody; Chlorocebus aethiops ANG antibody Q8WN66 85.0%
ARP48092 Hamadryas baboon ANG antibody; Papio hamadryas ANG antibody Q8WN64 93.0%
ARP48093 Hamadryas baboon ANG antibody; Papio hamadryas ANG antibody Q8WN64 86.0%
ARP48093 Horse ANG antibody; Equus caballus ANG antibody Q5VI84 93.0%
ARP48092 Horse ANG antibody; Equus caballus ANG antibody Q5VI84 79.0%
ARP41921 Human ANG antibody; Homo sapiens ANG antibody P03950 100.0%
ARP48092 Human ANG antibody; Homo sapiens ANG antibody P03950 100.0%
ARP48093 Human ANG antibody; Homo sapiens ANG antibody P03950 100.0%
ARP41921 Lowland gorilla ANG antibody; Gorilla gorilla gorilla ANG antibody Q71MJ0 100.0%
ARP48092 Lowland gorilla ANG antibody; Gorilla gorilla gorilla ANG antibody Q71MJ0 100.0%
ARP48093 Lowland gorilla ANG antibody; Gorilla gorilla gorilla ANG antibody Q71MJ0 100.0%
ARP48092 Mantled guereza ANG antibody; Colobus guereza ANG antibody Q861Y5 93.0%
ARP48093 Mantled guereza ANG antibody; Colobus guereza ANG antibody Q861Y5 92.0%
ARP41921 Mantled guereza ANG antibody; Colobus guereza ANG antibody Q861Y5 85.0%
ARP48092 Mouse ANG antibody; Mus musculus ANG antibody P21570 79.0%
ARP48093 Mouse ANG antibody; Mus musculus ANG antibody P21570 79.0%
ARP48092 Mouse ANG antibody; Mus musculus ANG antibody Q3TBG7 79.0%
ARP48093 Mouse ANG antibody; Mus musculus ANG antibody Q3TBG7 79.0%
ARP48093 Night monkey ANG antibody; Aotus trivirgatus ANG antibody Q8WN61 93.0%
ARP48092 Night monkey ANG antibody; Aotus trivirgatus ANG antibody Q8WN61 86.0%
ARP48092 Pig ANG antibody; Sus scrofa ANG antibody P31346 83.0%
ARP48092 Rabbit ANG antibody; Oryctolagus cuniculus ANG antibody P31347 79.0%
ARP48092 Rat ANG antibody; Rattus norvegicus ANG antibody Q5GAM6 83.0%
ARP48092 Rat ANG antibody; Rattus norvegicus ANG antibody Q5WRG2 83.0%
ARP48093 Rhesus macaque ANG antibody; Macaca mulatta ANG antibody H9EY03 93.0%
ARP48092 Rhesus macaque ANG antibody; Macaca mulatta ANG antibody Q8WN63 93.0%
ARP48093 Rhesus macaque ANG antibody; Macaca mulatta ANG antibody Q8WN63 93.0%
ARP48093 Small-eared galago ANG antibody; Otolemur garnettii ANG antibody H0XKP6 93.0%
ARP41921 Thirteen-lined ground squirrel ANG antibody; Spermophilus tridecemlineatus ANG antibody I3N9W4 92.0%
ARP48092 Thirteen-lined ground squirrel ANG antibody; Spermophilus tridecemlineatus ANG antibody I3N9W4 79.0%
ARP48093 Thirteen-lined ground squirrel ANG antibody; Spermophilus tridecemlineatus ANG antibody I3N9W4 79.0%
ARP48092 Tonkin snub-nosed monkey ANG antibody; Rhinopithecus avunculus ANG antibody Q861Y1 93.0%
ARP48093 Tonkin snub-nosed monkey ANG antibody; Rhinopithecus avunculus ANG antibody Q861Y1 93.0%
ARP41921 Tonkin snub-nosed monkey ANG antibody; Rhinopithecus avunculus ANG antibody Q861Y1 85.0%
ARP48092 White-tufted-ear marmoset ANG antibody; Callithrix jacchus ANG antibody F7GKZ5 93.0%
ARP48093 White-tufted-ear marmoset ANG antibody; Callithrix jacchus ANG antibody F7GKZ5 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas205141_at721_B_lymphoblasts6.10044.290Details
BioGPS Gene Atlas205141_atAdipocyte17.65044.290Details
BioGPS Gene Atlas205141_atAdrenalCortex5.50044.290Details
BioGPS Gene Atlas205141_atAdrenalgland11.90044.290Details
BioGPS Gene Atlas205141_atAmygdala5.15044.290Details
BioGPS Gene Atlas205141_atAppendix6.35044.290Details
BioGPS Gene Atlas205141_atAtrioventricularNode4.50044.290Details
BioGPS Gene Atlas205141_atBDCA4+_DentriticCells5.20044.290Details
BioGPS Gene Atlas205141_atBonemarrow5.15044.290Details
BioGPS Gene Atlas205141_atBronchialEpithelialCells5.20044.290Details
BioGPS Gene Atlas205141_atCD105+_Endothelial5.10044.290Details
BioGPS Gene Atlas205141_atCD14+_Monocytes6.20044.290Details
BioGPS Gene Atlas205141_atCD19+_BCells(neg._sel.)5.30044.290Details
BioGPS Gene Atlas205141_atCD33+_Myeloid13.20044.290Details
BioGPS Gene Atlas205141_atCD34+6.35044.290Details
BioGPS Gene Atlas205141_atCD4+_Tcells5.25044.290Details
BioGPS Gene Atlas205141_atCD56+_NKCells5.75044.290Details
BioGPS Gene Atlas205141_atCD71+_EarlyErythroid4.75044.290Details
BioGPS Gene Atlas205141_atCD8+_Tcells4.70044.290Details
BioGPS Gene Atlas205141_atCardiacMyocytes7.00044.290Details
BioGPS Gene Atlas205141_atCaudatenucleus4.65044.290Details
BioGPS Gene Atlas205141_atCerebellum4.20044.290Details
BioGPS Gene Atlas205141_atCerebellumPeduncles5.95044.290Details
BioGPS Gene Atlas205141_atCiliaryGanglion4.05044.290Details
BioGPS Gene Atlas205141_atCingulateCortex5.30044.290Details
BioGPS Gene Atlas205141_atColorectaladenocarcinoma5.10044.290Details
BioGPS Gene Atlas205141_atDorsalRootGanglion4.00044.290Details
BioGPS Gene Atlas205141_atFetalThyroid5.05044.290Details
BioGPS Gene Atlas205141_atFetalbrain5.00044.290Details
BioGPS Gene Atlas205141_atFetalliver144.30044.290Details
BioGPS Gene Atlas205141_atFetallung5.30044.290Details
BioGPS Gene Atlas205141_atGlobusPallidus3.80044.290Details
BioGPS Gene Atlas205141_atHeart6.90044.290Details
BioGPS Gene Atlas205141_atHypothalamus5.45044.290Details
BioGPS Gene Atlas205141_atKidney4.45044.290Details
BioGPS Gene Atlas205141_atLeukemia_chronicMyelogenousK-5624.60044.290Details
BioGPS Gene Atlas205141_atLeukemia_promyelocytic-HL-604.50044.290Details
BioGPS Gene Atlas205141_atLeukemialymphoblastic(MOLT-4)4.00044.290Details
BioGPS Gene Atlas205141_atLiver3121.75044.290Details
BioGPS Gene Atlas205141_atLung11.40044.290Details
BioGPS Gene Atlas205141_atLymphnode4.30044.290Details
BioGPS Gene Atlas205141_atLymphoma_burkitts(Daudi)6.65044.290Details
BioGPS Gene Atlas205141_atLymphoma_burkitts(Raji)7.35044.290Details
BioGPS Gene Atlas205141_atMedullaOblongata4.60044.290Details
BioGPS Gene Atlas205141_atOccipitalLobe4.55044.290Details
BioGPS Gene Atlas205141_atOlfactoryBulb6.05044.290Details
BioGPS Gene Atlas205141_atOvary38.10044.290Details
BioGPS Gene Atlas205141_atPancreas4.25044.290Details
BioGPS Gene Atlas205141_atPancreaticIslet8.00044.290Details
BioGPS Gene Atlas205141_atParietalLobe5.55044.290Details
BioGPS Gene Atlas205141_atPituitary6.40044.290Details
BioGPS Gene Atlas205141_atPlacenta6.20044.290Details
BioGPS Gene Atlas205141_atPons6.15044.290Details
BioGPS Gene Atlas205141_atPrefrontalCortex6.15044.290Details
BioGPS Gene Atlas205141_atProstate8.10044.290Details
BioGPS Gene Atlas205141_atSalivarygland6.95044.290Details
BioGPS Gene Atlas205141_atSkeletalMuscle6.55044.290Details
BioGPS Gene Atlas205141_atSkin4.10044.290Details
BioGPS Gene Atlas205141_atSmoothMuscle5.80044.290Details
BioGPS Gene Atlas205141_atSpinalcord5.55044.290Details
BioGPS Gene Atlas205141_atSubthalamicNucleus4.75044.290Details
BioGPS Gene Atlas205141_atSuperiorCervicalGanglion6.05044.290Details
BioGPS Gene Atlas205141_atTemporalLobe4.70044.290Details
BioGPS Gene Atlas205141_atTestis7.90044.290Details
BioGPS Gene Atlas205141_atTestisGermCell14.25044.290Details
BioGPS Gene Atlas205141_atTestisIntersitial4.35044.290Details
BioGPS Gene Atlas205141_atTestisLeydigCell5.95044.290Details
BioGPS Gene Atlas205141_atTestisSeminiferousTubule11.75044.290Details
BioGPS Gene Atlas205141_atThalamus5.20044.290Details
BioGPS Gene Atlas205141_atThymus3.90044.290Details
BioGPS Gene Atlas205141_atThyroid6.35044.290Details
BioGPS Gene Atlas205141_atTongue5.40044.290Details
BioGPS Gene Atlas205141_atTonsil4.95044.290Details
BioGPS Gene Atlas205141_atTrachea26.10044.290Details
BioGPS Gene Atlas205141_atTrigeminalGanglion5.35044.290Details
BioGPS Gene Atlas205141_atUterus4.80044.290Details
BioGPS Gene Atlas205141_atUterusCorpus4.70044.290Details
BioGPS Gene Atlas205141_atWholeBlood5.45044.290Details
BioGPS Gene Atlas205141_atWholebrain4.20044.290Details
BioGPS Gene Atlas205141_atcolon47.20044.290Details
BioGPS Gene Atlas205141_atpineal_day6.24044.290Details
BioGPS Gene Atlas205141_atpineal_night6.02044.290Details
BioGPS Gene Atlas205141_atretina6.17544.290Details
BioGPS Gene Atlas205141_atsmall_intestine24.15044.290Details
BioGPS NCI60205141_at7864.8898.270Details
BioGPS NCI60205141_atA1724.3758.270Details
BioGPS NCI60205141_atA2044.6898.270Details
BioGPS NCI60205141_atA3614.6998.270Details
BioGPS NCI60205141_atA4985.0048.270Details
BioGPS NCI60205141_atA5498.2728.270Details
BioGPS NCI60205141_atACC34.9908.270Details
BioGPS NCI60205141_atACHN4.2528.270Details
BioGPS NCI60205141_atALVA315.8148.270Details
BioGPS NCI60205141_atCAKI14.8908.270Details
BioGPS NCI60205141_atCCRT CEM5.3928.270Details
BioGPS NCI60205141_atCOLO20510.6888.270Details
BioGPS NCI60205141_atDLD14.5938.270Details
BioGPS NCI60205141_atDU1454.5338.270Details
BioGPS NCI60205141_atEKVX9.8218.270Details
BioGPS NCI60205141_atGM1334.8268.270Details
BioGPS NCI60205141_atGM16004.7598.270Details
BioGPS NCI60205141_atGM23134.8868.270Details
BioGPS NCI60205141_atGM23454.6188.270Details
BioGPS NCI60205141_atGM24935.0218.270Details
BioGPS NCI60205141_atGM974.9208.270Details
BioGPS NCI60205141_atHCC29984.2058.270Details
BioGPS NCI60205141_atHCT11612.7718.270Details
BioGPS NCI60205141_atHCT1529.7988.270Details
BioGPS NCI60205141_atHEK 293 T-rex4.9088.270Details
BioGPS NCI60205141_atHEK 293T4.6738.270Details
BioGPS NCI60205141_atHEK2934.6058.270Details
BioGPS NCI60205141_atHELA4.2958.270Details
BioGPS NCI60205141_atHEPG2290.2608.270Details
BioGPS NCI60205141_atHL604.7878.270Details
BioGPS NCI60205141_atHOP624.6278.270Details
BioGPS NCI60205141_atHOP924.9628.270Details
BioGPS NCI60205141_atHS578T4.6118.270Details
BioGPS NCI60205141_atHSG4.6288.270Details
BioGPS NCI60205141_atHT10804.5488.270Details
BioGPS NCI60205141_atHT294.8558.270Details
BioGPS NCI60205141_atIGROV14.6418.270Details
BioGPS NCI60205141_atIOSE804.5798.270Details
BioGPS NCI60205141_atJURKAT4.7008.270Details
BioGPS NCI60205141_atK5624.8228.270Details
BioGPS NCI60205141_atKM124.9718.270Details
BioGPS NCI60205141_atLN184.3918.270Details
BioGPS NCI60205141_atLNCAP5.1828.270Details
BioGPS NCI60205141_atLOX IMVI4.7158.270Details
BioGPS NCI60205141_atM144.6878.270Details
BioGPS NCI60205141_atMALME 3M5.0278.270Details
BioGPS NCI60205141_atMCF74.4518.270Details
BioGPS NCI60205141_atMD MB2314.7858.270Details
BioGPS NCI60205141_atMDA MB4355.1318.270Details
BioGPS NCI60205141_atMOLT44.8618.270Details
BioGPS NCI60205141_atNCI 46019.8198.270Details
BioGPS NCI60205141_atNCI H2265.8948.270Details
BioGPS NCI60205141_atNCI H235.7398.270Details
BioGPS NCI60205141_atNCI H322M5.4638.270Details
BioGPS NCI60205141_atNCVADR RES9.7268.270Details
BioGPS NCI60205141_atOVCAR34.7928.270Details
BioGPS NCI60205141_atOVCAR44.5668.270Details
BioGPS NCI60205141_atOVCAR54.3708.270Details
BioGPS NCI60205141_atOVCAR84.3118.270Details
BioGPS NCI60205141_atPANC16.2798.270Details
BioGPS NCI60205141_atRL74.6248.270Details
BioGPS NCI60205141_atRPMI 82264.7498.270Details
BioGPS NCI60205141_atRS118464.7368.270Details
BioGPS NCI60205141_atRXF3934.6518.270Details
BioGPS NCI60205141_atSAOS24.7798.270Details
BioGPS NCI60205141_atSF2684.5958.270Details
BioGPS NCI60205141_atSF2954.5198.270Details
BioGPS NCI60205141_atSF5394.3088.270Details
BioGPS NCI60205141_atSHSYSY+RA4.4298.270Details
BioGPS NCI60205141_atSHSYSY-RA4.5728.270Details
BioGPS NCI60205141_atSKMEL24.6848.270Details
BioGPS NCI60205141_atSKMEL285.5338.270Details
BioGPS NCI60205141_atSKMEL58.7568.270Details
BioGPS NCI60205141_atSKOV34.9288.270Details
BioGPS NCI60205141_atSN12C5.1628.270Details
BioGPS NCI60205141_atSNB196.0468.270Details
BioGPS NCI60205141_atSNB754.5768.270Details
BioGPS NCI60205141_atSR4.9428.270Details
BioGPS NCI60205141_atSW6204.6588.270Details
BioGPS NCI60205141_atT244.7388.270Details
BioGPS NCI60205141_atT3M44.8918.270Details
BioGPS NCI60205141_atTK104.6178.270Details
BioGPS NCI60205141_atU1184.5828.270Details
BioGPS NCI60205141_atU1384.5658.270Details
BioGPS NCI60205141_atU20S4.5678.270Details
BioGPS NCI60205141_atU2514.5738.270Details
BioGPS NCI60205141_atU874.4718.270Details
BioGPS NCI60205141_atUACC2574.5498.270Details
BioGPS NCI60205141_atUACC629.6338.270Details
BioGPS NCI60205141_atUO314.4458.270Details
BioGPS NCI60205141_atZR75_110.5088.270Details
BioGPS NCI60205141_atastrocytes4.7068.270Details
BioGPS NCI60205141_athuh-74.9558.270Details