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Gene ID: 10189 | ALYREF Antibody Resource


ALYREF Antibody Resource
Gene Full Name: 
Aly/REF export factor
Uniprot: 
Q86V81
Protein Name: 
THO complex subunit 4
Nucleotide: 
NM_005782
Alias: 
ALY;BEF;REF;THOC4;ALY/REF;
Ensembl: 
ENSG00000183684
Location: 
17q25.3
HPRD: 
09168
NCBI Gene: 
10189
MIM: 
604171

Summary: 
The protein encoded by this gene is a heat stable, nuclear protein and functions as a molecular chaperone. It is thought to regulate dimerization, DNA binding, and transcriptional activity of basic region-leucine zipper (bZIP) proteins. [provided by RefSeq, Jul 2008]
Function: 
Export adapter involved in nuclear export of spliced and unspliced mRNA. Binds mRNA which is thought to be transferred to the NXF1-NXT1 heterodimer for export (TAP/NFX1 pathway). Component of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm. TREX recruitment occurs via an interaction between ALYREF/THOC4 and the cap-binding protein NCBP1. The TREX complex is essential for the export of Kaposi's sarcoma-associated herpesvirus (KSHV) intronless mRNAs and infectious virus production; ALYREF/THOC4 mediates the recruitment of the TREX complex to the intronless viral mRNA. Required for TREX complex assembly and for linking DDX39B to the cap-binding complex (CBC). In conjunction with THOC5 functions in NXF1-NXT1 mediated nuclear export of HSP70 mRNA; both proteins enhance the RNA binding activity of NXF1 and are required for NXF1 localization to the nuclear rim. Involved in the nuclear export of intronless mRNA; proposed to be recruited to intronless mRNA by ATP-bound DDX39B. Involved in transcription elongation and genome stability.Acts as chaperone and promotes the dimerization of transcription factors containing basic leucine zipper (bZIP) domains and thereby promotes transcriptional activation.
Subcellular location: 
Nucleus. Nucleus speckle. Cytoplasm. Note: Colocalizes with the core EJC, ALYREF/THOC4, NXF1 and DDX39B in the nucleus and nuclear speckles. Travels to the cytoplasm as part of the exon junction complex (EJC) bound to mRNA. Localizes to regions surrounding nuclear speckles known as perispeckles in which TREX complex assembly seems to occur.
PTM: 
Acetylation;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP43055_T100 THOC4 antibody - N-terminal region (ARP43055_T100) Polyclonal Bovine, Human, Mouse, Rat IHC, WB 100ug $229 Details
Polyclonal Antibody OAAB11817 THOC4 antibody - center region (OAAB11817) Human WB 400ul $289 Details
Polyclonal Antibody OAEC03250 THOC4 Antibody (OAEC03250) Human; Mouse; Rat WB, ELISA 100ug $229 Details
Polyclonal Antibody OAGA01049 ALYREF antibody (OAGA01049) Polyclonal Human, Mouse ICC/IF, IHC (Formalin-fixed paraffin-embedded sections), WB 100 ul $340 Details
Polyclonal Antibody OAAF04517 ALYREF Antibody (OAAF04517) Polyclonal Human, Mouse, Rat WB, ELISA 100 ug $229 Details

Show all ALYREF antibodies


Product Images
THOC4 antibody - N-terminal region (ARP43055_T100) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

THOC4 antibody - N-terminal region (ARP43055_T100) in Human Lung cells using Immunohistochemistry

Sample Type: Human Lung

THOC4 antibody - center region (OAAB11817) in A549 cells using Western Blot

Sample Type: A549

ALYREF Antibody (OAAF04517) in LOVO, K562 cells using Western Blot

Sample Type: LOVO, K562

THOC4 Antibody (OAEC03250) in LOVO cells using Western Blot

Sample Type: LOVO


ALYREF Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP43055 Bovine ALYREF antibody; Bos taurus ALYREF antibody Q3T0I4 100.0%
ARP43055 Chimpanzee ALYREF antibody; Pan troglodytes ALYREF antibody H2QE34 100.0%
ARP43055 Chimpanzee ALYREF antibody; Pan troglodytes ALYREF antibody K7CXE3 100.0%
ARP43055 Dog ALYREF antibody; Canis familiaris ALYREF antibody F1PL92 100.0%
ARP43055 Gray short-tailed opossum ALYREF antibody; Monodelphis domestica ALYREF antibody F6Q1W2 100.0%
ARP43055 Human ALYREF antibody; Homo sapiens ALYREF antibody E9PB61 100.0%
ARP43055 Human ALYREF antibody; Homo sapiens ALYREF antibody Q86V81 100.0%
ARP43055 Mouse ALYREF antibody; Mus musculus ALYREF antibody O08583 100.0%
ARP43055 Rat ALYREF antibody; Rattus norvegicus ALYREF antibody D3ZXH7 100.0%
ARP43055 Rhesus macaque ALYREF antibody; Macaca mulatta ALYREF antibody H9Z445 100.0%
ARP43055 Sumatran orangutan ALYREF antibody; Pongo abelii ALYREF antibody H2NV29 100.0%
ARP43055 Western clawed frog ALYREF antibody; Xenopus tropicalis ALYREF antibody Q28FB9 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3BHB6 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3D5V6 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3DEP7 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3E2X7 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3EDD7 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3EMW0 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3EVH7 100.0%
ARP43055 White-tufted-ear marmoset ALYREF antibody; Callithrix jacchus ALYREF antibody U3F3Z1 100.0%
ARP43055 Zebra finch ALYREF antibody; Taeniopygia guttata ALYREF antibody B5FXN8 93.0%
ARP43055 Zebrafish ALYREF antibody; Danio rerio ALYREF antibody A7MBY2 100.0%
ARP43055 Zebrafish ALYREF antibody; Danio rerio ALYREF antibody F1Q9D1 93.0%

Tissue & Cell Line Gene Expression Data