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Gene ID: 57679 | ALS2 Antibody Resource


ALS2 Antibody Resource
Gene Full Name: 
amyotrophic lateral sclerosis 2 (juvenile)
Uniprot: 
Q96Q42
Protein Name: 
alsin
Nucleotide: 
NM_020919
Alias: 
ALSJ;PLSJ;IAHSP;ALS2CR6;
Ensembl: 
ENSG00000003393
Location: 
2q33.1
HPRD: 
05893
NCBI Gene: 
57679
MIM: 
606352

Summary: 
The protein encoded by this gene contains an ATS1/RCC1-like domain, a RhoGEF domain, and a vacuolar protein sorting 9 (VPS9) domain, all of which are guanine-nucleotide exchange factors that activate members of the Ras superfamily of GTPases. The protein functions as a guanine nucleotide exchange factor for the small GTPase RAB5. The protein localizes with RAB5 on early endosomal compartments, and functions as a modulator for endosomal dynamics. Mutations in this gene result in several forms of juvenile lateral sclerosis and infantile-onset ascending spastic paralysis. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2008]
Function: 
May act as a GTPase regulator. Controls survival and growth of spinal motoneurons .
Subcellular location: 
PTM: 
Acetylation;
Disease: 
Amyotrophic lateral sclerosis 2 (ALS2) [MIM:205100]: A neurodegenerative disorder affecting upper motor neurons in the brain and lower motor neurons in the brain stem and spinal cord, resulting in fatal paralysis. Sensory abnormalities are absent. The pathologic hallmarks of the disease include pallor of the corticospinal tract due to loss of motor neurons, presence of ubiquitin-positive inclusions within surviving motor neurons, and deposition of pathologic aggregates. The etiology of amyotrophic lateral sclerosis is likely to be multifactorial, involving both genetic and environmental factors. The disease is inherited in 5-10% of the cases. Note: The disease is caused by mutations affecting the gene represented in this entry. Juvenile primary lateral sclerosis (JPLS) [MIM:606353]: A neurodegenerative disorder which is closely related to but clinically distinct from amyotrophic lateral sclerosis. It is a progressive paralytic disorder which results from dysfunction of the upper motor neurons while the lower neurons are unaffected. Note: The disease is caused by mutations affecting the gene represented in this entry. Infantile-onset ascending spastic paralysis (IAHSP) [MIM:607225]: Characterized by progressive spasticity and weakness of limbs. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP57487_P050 ALS2 antibody - middle region (ARP57487_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OAEB00925 Goat Anti-Alsin / ALS2 Antibody (OAEB00925) Bovine, Dog, Guinea pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish IHC 0.1mg $289 Details
Polyclonal Antibody OAAB03484 ALS2 antibody - C-terminal region (OAAB03484) Human; Mouse WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody ARP57488_P050 ALS2 Antibody (ARP57488_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details

Show all ALS2 antibodies


Product Images
ALS2 antibody - middle region (ARP57487_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

ALS2 antibody - C-terminal region (OAAB03484) in human brain cells using Immunohistochemistry

Sample Type: human brain

ALS2 antibody - C-terminal region (OAAB03484) in Mouse Lung cells using Western Blot

Sample Type: Mouse Lung

Goat Anti-Alsin / ALS2 Antibody (OAEB00925) in Human Cortex cells using Immunohistochemistry

Sample Type: Human Cortex


ALS2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP57487 African elephant ALS2 antibody; Loxodonta africana ALS2 antibody G3T8H3 100.0%
ARP57488 African elephant ALS2 antibody; Loxodonta africana ALS2 antibody G3T8H3 100.0%
ARP57487 Bovine ALS2 antibody; Bos taurus ALS2 antibody F1MDF3 100.0%
ARP57488 Bovine ALS2 antibody; Bos taurus ALS2 antibody F1MDF3 100.0%
ARP57487 Cat ALS2 antibody; Felis catus ALS2 antibody M3W1D7 100.0%
ARP57488 Cat ALS2 antibody; Felis catus ALS2 antibody M3W1D7 93.0%
ARP57487 Chicken ALS2 antibody; Gallus gallus ALS2 antibody E1BX75 100.0%
ARP57488 Chicken ALS2 antibody; Gallus gallus ALS2 antibody E1BX75 86.0%
ARP57487 Chimpanzee ALS2 antibody; Pan troglodytes ALS2 antibody Q5BIW4 100.0%
ARP57488 Chimpanzee ALS2 antibody; Pan troglodytes ALS2 antibody Q5BIW4 100.0%
ARP57487 Chimpanzee ALS2 antibody; Pan troglodytes ALS2 antibody H2QJ88 100.0%
ARP57488 Chimpanzee ALS2 antibody; Pan troglodytes ALS2 antibody H2QJ88 100.0%
ARP57487 Chinese softshell turtle ALS2 antibody; Pelodiscus sinensis ALS2 antibody K7FYB5 100.0%
ARP57488 Chinese softshell turtle ALS2 antibody; Pelodiscus sinensis ALS2 antibody K7FYB5 86.0%
ARP57487 Collared flycatcher ALS2 antibody; Ficedula albicollis ALS2 antibody U3JN94 100.0%
ARP57488 Collared flycatcher ALS2 antibody; Ficedula albicollis ALS2 antibody U3JN94 86.0%
ARP57487 Common turkey ALS2 antibody; Meleagris gallopavo ALS2 antibody G1N7S4 100.0%
ARP57488 Common turkey ALS2 antibody; Meleagris gallopavo ALS2 antibody G1N7S4 86.0%
ARP57487 Dog ALS2 antibody; Canis familiaris ALS2 antibody E2RSG1 100.0%
ARP57488 Dog ALS2 antibody; Canis familiaris ALS2 antibody E2RSG1 93.0%
ARP57487 Domestic duck ALS2 antibody; Anas platyrhynchos ALS2 antibody U3INX5 100.0%
ARP57488 Domestic duck ALS2 antibody; Anas platyrhynchos ALS2 antibody U3INX5 85.0%
ARP57488 Duckbill platypus ALS2 antibody; Ornithorhynchus anatinus ALS2 antibody F7G6R6 93.0%
ARP57487 European domestic ferret ALS2 antibody; Mustela putorius furo ALS2 antibody M3XML2 100.0%
ARP57488 European domestic ferret ALS2 antibody; Mustela putorius furo ALS2 antibody M3XML2 93.0%
ARP57487 Giant panda ALS2 antibody; Ailuropoda melanoleuca ALS2 antibody G1M3Y1 100.0%
ARP57488 Giant panda ALS2 antibody; Ailuropoda melanoleuca ALS2 antibody G1M3Y1 93.0%
ARP57488 Gray short-tailed opossum ALS2 antibody; Monodelphis domestica ALS2 antibody F7FL33 93.0%
ARP57487 Gray short-tailed opossum ALS2 antibody; Monodelphis domestica ALS2 antibody F7FL33 92.0%
ARP57487 Green anole ALS2 antibody; Anolis carolinensis ALS2 antibody H9G4L6 100.0%
ARP57488 Green anole ALS2 antibody; Anolis carolinensis ALS2 antibody H9G4L6 86.0%
ARP57487 Horse ALS2 antibody; Equus caballus ALS2 antibody F6RT17 100.0%
ARP57488 Horse ALS2 antibody; Equus caballus ALS2 antibody F6RT17 100.0%
ARP57487 Horse ALS2 antibody; Equus caballus ALS2 antibody F6S1V4 100.0%
ARP57488 Horse ALS2 antibody; Equus caballus ALS2 antibody F6S1V4 100.0%
ARP57487 Human ALS2 antibody; Homo sapiens ALS2 antibody B3KPJ0 100.0%
ARP57487 Human ALS2 antibody; Homo sapiens ALS2 antibody Q6IQ41 100.0%
ARP57487 Human ALS2 antibody; Homo sapiens ALS2 antibody Q96Q42 100.0%
ARP57488 Human ALS2 antibody; Homo sapiens ALS2 antibody Q96Q42 100.0%
ARP57487 Human ALS2 antibody; Homo sapiens ALS2 antibody H0Y696 100.0%
ARP57487 Mouse ALS2 antibody; Mus musculus ALS2 antibody Q3TAJ7 100.0%
ARP57488 Mouse ALS2 antibody; Mus musculus ALS2 antibody Q3TAJ7 100.0%
ARP57487 Mouse ALS2 antibody; Mus musculus ALS2 antibody Q920R0 100.0%
ARP57488 Mouse ALS2 antibody; Mus musculus ALS2 antibody Q920R0 100.0%
ARP57487 Pig ALS2 antibody; Sus scrofa ALS2 antibody F1SI31 100.0%
ARP57488 Pig ALS2 antibody; Sus scrofa ALS2 antibody F1SI31 93.0%
ARP57488 Rabbit ALS2 antibody; Oryctolagus cuniculus ALS2 antibody G1T3G9 100.0%
ARP57487 Rabbit ALS2 antibody; Oryctolagus cuniculus ALS2 antibody G1T3G9 93.0%
ARP57487 Rat ALS2 antibody; Rattus norvegicus ALS2 antibody P0C5Y8 100.0%
ARP57488 Rat ALS2 antibody; Rattus norvegicus ALS2 antibody P0C5Y8 100.0%
ARP57487 Rhesus macaque ALS2 antibody; Macaca mulatta ALS2 antibody H9FXQ9 100.0%
ARP57488 Rhesus macaque ALS2 antibody; Macaca mulatta ALS2 antibody H9FXQ9 100.0%
ARP57487 Small-eared galago ALS2 antibody; Otolemur garnettii ALS2 antibody H0X3E6 100.0%
ARP57488 Small-eared galago ALS2 antibody; Otolemur garnettii ALS2 antibody H0X3E6 100.0%
ARP57487 Sumatran orangutan ALS2 antibody; Pongo abelii ALS2 antibody H2P8B1 100.0%
ARP57488 Sumatran orangutan ALS2 antibody; Pongo abelii ALS2 antibody H2P8B1 100.0%
ARP57487 Tasmanian devil ALS2 antibody; Sarcophilus harrisii ALS2 antibody G3WP72 93.0%
ARP57488 Tasmanian devil ALS2 antibody; Sarcophilus harrisii ALS2 antibody G3WP72 93.0%
ARP57487 Tasmanian devil ALS2 antibody; Sarcophilus harrisii ALS2 antibody G3WP73 93.0%
ARP57488 Tasmanian devil ALS2 antibody; Sarcophilus harrisii ALS2 antibody G3WP73 93.0%
ARP57487 Western clawed frog ALS2 antibody; Xenopus tropicalis ALS2 antibody F6RL74 79.0%
ARP57487 Western clawed frog ALS2 antibody; Xenopus tropicalis ALS2 antibody F6WUQ5 79.0%
ARP57487 Western clawed frog ALS2 antibody; Xenopus tropicalis ALS2 antibody Q08D45 79.0%
ARP57487 White-tufted-ear marmoset ALS2 antibody; Callithrix jacchus ALS2 antibody U3ET15 100.0%
ARP57488 White-tufted-ear marmoset ALS2 antibody; Callithrix jacchus ALS2 antibody U3ET15 100.0%
ARP57487 White-tufted-ear marmoset ALS2 antibody; Callithrix jacchus ALS2 antibody F7I5R0 100.0%
ARP57488 White-tufted-ear marmoset ALS2 antibody; Callithrix jacchus ALS2 antibody F7I5R0 100.0%
ARP57487 Zebra finch ALS2 antibody; Taeniopygia guttata ALS2 antibody H0ZIY5 100.0%
ARP57488 Zebra finch ALS2 antibody; Taeniopygia guttata ALS2 antibody H0ZIY5 86.0%

Tissue & Cell Line Gene Expression Data