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Gene ID: 241 | ALOX5AP Antibody Resource


ALOX5AP Antibody Resource
Gene Full Name: 
arachidonate 5-lipoxygenase-activating protein
Uniprot: 
P20292
Protein Name: 
arachidonate 5-lipoxygenase-activating protein
Nucleotide: 
NM_001204406
Alias: 
FLAP;
Ensembl: 
ENSG00000132965
Location: 
13q12
HPRD: 
04742
NCBI Gene: 
241
MIM: 
603700

Summary: 
This gene encodes a protein which, with 5-lipoxygenase, is required for leukotriene synthesis. Leukotrienes are arachidonic acid metabolites which have been implicated in various types of inflammatory responses, including asthma, arthritis and psoriasis. This protein localizes to the plasma membrane. Inhibitors of its function impede translocation of 5-lipoxygenase from the cytoplasm to the cell membrane and inhibit 5-lipoxygenase activation. Alternatively spliced transcript variants encoding different isoforms have been identified for this gene. [provided by RefSeq, Feb 2011]
Function: 
Required for leukotriene biosynthesis by ALOX5 (5-lipoxygenase). Anchors ALOX5 to the membrane. Binds arachidonic acid, and could play an essential role in the transfer of arachidonic acid to ALOX5. Binds to MK-886, a compound that blocks the biosynthesis of leukotrienes.
Subcellular location: 
Nucleus membrane; Multi-pass membrane protein. Endoplasmic reticulum membrane; Multi-pass membrane protein .
PTM: 
Disease: 
Ischemic stroke (ISCHSTR) [MIM:601367]: A stroke is an acute neurologic event leading to death of neural tissue of the brain and resulting in loss of motor, sensory and/or cognitive function. Ischemic strokes, resulting from vascular occlusion, is considered to be a highly complex disease consisting of a group of heterogeneous disorders with multiple genetic and environmental risk factors. Note: Disease susceptibility is associated with variations affecting the gene represented in this entry. Genetic variations in ALOX5AP may be associated with susceptibility to myocardial infarction. Involvement in myocardial infarction is however unclear: according to some authors (), a 4-SNP haplotype in ALOX5AP confers risk of myocardial infarction, while according to other () ALOX5AP is not implicated in this condition.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAEB01148 Goat Anti-FLAP / ALOX5AP (internal) Antibody (OAEB01148) Dog, Guinea pig, Horse WB, IHC 0.1mg $289 Details
Polyclonal Antibody OAEB01908 Goat Anti-FLAP / ALOX5AP (C Term) Antibody (OAEB01908) Dog, Guinea pig, Horse, Pig ELISA, WB 0.1mg $289 Details
Polyclonal Antibody OAAB04978 ALOX5AP antibody - C-terminal region (OAAB04978) Human; Mouse WB, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAAB04979 ALOX5AP antibody - center region (OAAB04979) Human WB, IHC, ELISA 400ul $289 Details

Show all ALOX5AP antibodies


Product Images
ALOX5AP antibody - center region (OAAB04979) in human lung carcinoma cells using Immunohistochemistry

Sample Type: human lung carcinoma

ALOX5AP antibody - center region (OAAB04979) in K562 cells using Western Blot

Sample Type: K562

Goat Anti-FLAP / ALOX5AP (internal) Antibody (OAEB01148) in Human spleen cells using Immunohistochemistry

Sample Type: Human spleen

Goat Anti-FLAP / ALOX5AP (internal) Antibody (OAEB01148) in Human U937 cells using Western Blot

Sample Type: Human U937


ALOX5AP Protocols

Publications
Related Gene Trend Categories
Species
Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas204174_at721_B_lymphoblasts269.700133.180Details
BioGPS Gene Atlas204174_atAdipocyte5.600133.180Details
BioGPS Gene Atlas204174_atAdrenalCortex5.850133.180Details
BioGPS Gene Atlas204174_atAdrenalgland5.300133.180Details
BioGPS Gene Atlas204174_atAmygdala8.050133.180Details
BioGPS Gene Atlas204174_atAppendix5.550133.180Details
BioGPS Gene Atlas204174_atAtrioventricularNode4.600133.180Details
BioGPS Gene Atlas204174_atBDCA4+_DentriticCells2744.900133.180Details
BioGPS Gene Atlas204174_atBonemarrow1461.250133.180Details
BioGPS Gene Atlas204174_atBronchialEpithelialCells7.650133.180Details
BioGPS Gene Atlas204174_atCD105+_Endothelial5.550133.180Details
BioGPS Gene Atlas204174_atCD14+_Monocytes384.250133.180Details
BioGPS Gene Atlas204174_atCD19+_BCells(neg._sel.)591.750133.180Details
BioGPS Gene Atlas204174_atCD33+_Myeloid765.600133.180Details
BioGPS Gene Atlas204174_atCD34+68.350133.180Details
BioGPS Gene Atlas204174_atCD4+_Tcells362.450133.180Details
BioGPS Gene Atlas204174_atCD56+_NKCells666.300133.180Details
BioGPS Gene Atlas204174_atCD71+_EarlyErythroid5.300133.180Details
BioGPS Gene Atlas204174_atCD8+_Tcells319.800133.180Details
BioGPS Gene Atlas204174_atCardiacMyocytes7.100133.180Details
BioGPS Gene Atlas204174_atCaudatenucleus6.900133.180Details
BioGPS Gene Atlas204174_atCerebellum4.550133.180Details
BioGPS Gene Atlas204174_atCerebellumPeduncles6.550133.180Details
BioGPS Gene Atlas204174_atCiliaryGanglion3.950133.180Details
BioGPS Gene Atlas204174_atCingulateCortex5.600133.180Details
BioGPS Gene Atlas204174_atColorectaladenocarcinoma5.550133.180Details
BioGPS Gene Atlas204174_atDorsalRootGanglion4.250133.180Details
BioGPS Gene Atlas204174_atFetalThyroid5.450133.180Details
BioGPS Gene Atlas204174_atFetalbrain6.400133.180Details
BioGPS Gene Atlas204174_atFetalliver4.800133.180Details
BioGPS Gene Atlas204174_atFetallung26.500133.180Details
BioGPS Gene Atlas204174_atGlobusPallidus4.050133.180Details
BioGPS Gene Atlas204174_atHeart8.800133.180Details
BioGPS Gene Atlas204174_atHypothalamus23.000133.180Details
BioGPS Gene Atlas204174_atKidney4.450133.180Details
BioGPS Gene Atlas204174_atLeukemia_chronicMyelogenousK-5625.200133.180Details
BioGPS Gene Atlas204174_atLeukemia_promyelocytic-HL-60145.250133.180Details
BioGPS Gene Atlas204174_atLeukemialymphoblastic(MOLT-4)8.200133.180Details
BioGPS Gene Atlas204174_atLiver7.850133.180Details
BioGPS Gene Atlas204174_atLung534.800133.180Details
BioGPS Gene Atlas204174_atLymphnode82.750133.180Details
BioGPS Gene Atlas204174_atLymphoma_burkitts(Daudi)291.850133.180Details
BioGPS Gene Atlas204174_atLymphoma_burkitts(Raji)496.300133.180Details
BioGPS Gene Atlas204174_atMedullaOblongata5.150133.180Details
BioGPS Gene Atlas204174_atOccipitalLobe5.150133.180Details
BioGPS Gene Atlas204174_atOlfactoryBulb8.500133.180Details
BioGPS Gene Atlas204174_atOvary4.150133.180Details
BioGPS Gene Atlas204174_atPancreas4.500133.180Details
BioGPS Gene Atlas204174_atPancreaticIslet18.950133.180Details
BioGPS Gene Atlas204174_atParietalLobe6.300133.180Details
BioGPS Gene Atlas204174_atPituitary7.350133.180Details
BioGPS Gene Atlas204174_atPlacenta22.850133.180Details
BioGPS Gene Atlas204174_atPons5.250133.180Details
BioGPS Gene Atlas204174_atPrefrontalCortex6.500133.180Details
BioGPS Gene Atlas204174_atProstate6.550133.180Details
BioGPS Gene Atlas204174_atSalivarygland22.800133.180Details
BioGPS Gene Atlas204174_atSkeletalMuscle6.350133.180Details
BioGPS Gene Atlas204174_atSkin4.300133.180Details
BioGPS Gene Atlas204174_atSmoothMuscle6.450133.180Details
BioGPS Gene Atlas204174_atSpinalcord20.050133.180Details
BioGPS Gene Atlas204174_atSubthalamicNucleus5.200133.180Details
BioGPS Gene Atlas204174_atSuperiorCervicalGanglion6.700133.180Details
BioGPS Gene Atlas204174_atTemporalLobe5.350133.180Details
BioGPS Gene Atlas204174_atTestis4.750133.180Details
BioGPS Gene Atlas204174_atTestisGermCell4.500133.180Details
BioGPS Gene Atlas204174_atTestisIntersitial4.700133.180Details
BioGPS Gene Atlas204174_atTestisLeydigCell5.450133.180Details
BioGPS Gene Atlas204174_atTestisSeminiferousTubule4.700133.180Details
BioGPS Gene Atlas204174_atThalamus12.000133.180Details
BioGPS Gene Atlas204174_atThymus181.700133.180Details
BioGPS Gene Atlas204174_atThyroid7.150133.180Details
BioGPS Gene Atlas204174_atTongue5.500133.180Details
BioGPS Gene Atlas204174_atTonsil88.950133.180Details
BioGPS Gene Atlas204174_atTrachea6.150133.180Details
BioGPS Gene Atlas204174_atTrigeminalGanglion5.950133.180Details
BioGPS Gene Atlas204174_atUterus5.050133.180Details
BioGPS Gene Atlas204174_atUterusCorpus5.150133.180Details
BioGPS Gene Atlas204174_atWholeBlood1715.600133.180Details
BioGPS Gene Atlas204174_atWholebrain4.850133.180Details
BioGPS Gene Atlas204174_atcolon5.700133.180Details
BioGPS Gene Atlas204174_atpineal_day7.040133.180Details
BioGPS Gene Atlas204174_atpineal_night6.660133.180Details
BioGPS Gene Atlas204174_atretina18.625133.180Details
BioGPS Gene Atlas204174_atsmall_intestine13.900133.180Details
BioGPS NCI60204174_at78615.39486.710Details
BioGPS NCI60204174_atA1723.87686.710Details
BioGPS NCI60204174_atA2044.03886.710Details
BioGPS NCI60204174_atA3614.09686.710Details
BioGPS NCI60204174_atA4984.07886.710Details
BioGPS NCI60204174_atA5495.45186.710Details
BioGPS NCI60204174_atACC34.17986.710Details
BioGPS NCI60204174_atACHN237.05486.710Details
BioGPS NCI60204174_atALVA314.32386.710Details
BioGPS NCI60204174_atCAKI14.19386.710Details
BioGPS NCI60204174_atCCRT CEM13.26786.710Details
BioGPS NCI60204174_atCOLO2054.06686.710Details
BioGPS NCI60204174_atDLD14.00286.710Details
BioGPS NCI60204174_atDU1453.91386.710Details
BioGPS NCI60204174_atEKVX3.95686.710Details
BioGPS NCI60204174_atGM1334.16486.710Details
BioGPS NCI60204174_atGM16004.22086.710Details
BioGPS NCI60204174_atGM23134.12986.710Details
BioGPS NCI60204174_atGM23454.09786.710Details
BioGPS NCI60204174_atGM24934.22586.710Details
BioGPS NCI60204174_atGM974.46486.710Details
BioGPS NCI60204174_atHCC29983.75386.710Details
BioGPS NCI60204174_atHCT1164.05286.710Details
BioGPS NCI60204174_atHCT153.88586.710Details
BioGPS NCI60204174_atHEK 293 T-rex4.22886.710Details
BioGPS NCI60204174_atHEK 293T4.05986.710Details
BioGPS NCI60204174_atHEK2934.05186.710Details
BioGPS NCI60204174_atHELA3.88586.710Details
BioGPS NCI60204174_atHEPG24.12486.710Details
BioGPS NCI60204174_atHL60996.35586.710Details
BioGPS NCI60204174_atHOP624.07986.710Details
BioGPS NCI60204174_atHOP923.96986.710Details
BioGPS NCI60204174_atHS578T3.99286.710Details
BioGPS NCI60204174_atHSG3.95886.710Details
BioGPS NCI60204174_atHT10806.68986.710Details
BioGPS NCI60204174_atHT294.35686.710Details
BioGPS NCI60204174_atIGROV14.01886.710Details
BioGPS NCI60204174_atIOSE804.03186.710Details
BioGPS NCI60204174_atJURKAT1179.72086.710Details
BioGPS NCI60204174_atK5624.25486.710Details
BioGPS NCI60204174_atKM124.20986.710Details
BioGPS NCI60204174_atLN183.93086.710Details
BioGPS NCI60204174_atLNCAP4.05586.710Details
BioGPS NCI60204174_atLOX IMVI4.05586.710Details
BioGPS NCI60204174_atM144.00786.710Details
BioGPS NCI60204174_atMALME 3M4.20886.710Details
BioGPS NCI60204174_atMCF73.93186.710Details
BioGPS NCI60204174_atMD MB2314.05686.710Details
BioGPS NCI60204174_atMDA MB4354.19586.710Details
BioGPS NCI60204174_atMOLT499.58586.710Details
BioGPS NCI60204174_atNCI 4604.14186.710Details
BioGPS NCI60204174_atNCI H2264.16286.710Details
BioGPS NCI60204174_atNCI H234.05086.710Details
BioGPS NCI60204174_atNCI H322M4.05586.710Details
BioGPS NCI60204174_atNCVADR RES3.87886.710Details
BioGPS NCI60204174_atOVCAR34.17786.710Details
BioGPS NCI60204174_atOVCAR44.04186.710Details
BioGPS NCI60204174_atOVCAR53.99486.710Details
BioGPS NCI60204174_atOVCAR83.67986.710Details
BioGPS NCI60204174_atPANC14.08986.710Details
BioGPS NCI60204174_atRL72793.99086.710Details
BioGPS NCI60204174_atRPMI 822651.29986.710Details
BioGPS NCI60204174_atRS118462355.50586.710Details
BioGPS NCI60204174_atRXF393224.32286.710Details
BioGPS NCI60204174_atSAOS24.11986.710Details
BioGPS NCI60204174_atSF2684.06486.710Details
BioGPS NCI60204174_atSF2954.00586.710Details
BioGPS NCI60204174_atSF5393.88486.710Details
BioGPS NCI60204174_atSHSYSY+RA3.81086.710Details
BioGPS NCI60204174_atSHSYSY-RA4.01386.710Details
BioGPS NCI60204174_atSKMEL24.03486.710Details
BioGPS NCI60204174_atSKMEL284.07286.710Details
BioGPS NCI60204174_atSKMEL53.76786.710Details
BioGPS NCI60204174_atSKOV34.09386.710Details
BioGPS NCI60204174_atSN12C4.03186.710Details
BioGPS NCI60204174_atSNB193.89886.710Details
BioGPS NCI60204174_atSNB754.04586.710Details
BioGPS NCI60204174_atSR4.30186.710Details
BioGPS NCI60204174_atSW6204.11286.710Details
BioGPS NCI60204174_atT244.12786.710Details
BioGPS NCI60204174_atT3M44.24486.710Details
BioGPS NCI60204174_atTK104.06286.710Details
BioGPS NCI60204174_atU1184.03786.710Details
BioGPS NCI60204174_atU1384.01186.710Details
BioGPS NCI60204174_atU20S6.01686.710Details
BioGPS NCI60204174_atU2514.01086.710Details
BioGPS NCI60204174_atU873.99586.710Details
BioGPS NCI60204174_atUACC2573.99686.710Details
BioGPS NCI60204174_atUACC624.10286.710Details
BioGPS NCI60204174_atUO313.95286.710Details
BioGPS NCI60204174_atZR75_14.09386.710Details
BioGPS NCI60204174_atastrocytes4.22986.710Details
BioGPS NCI60204174_athuh-74.24186.710Details