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Gene ID: 242 | ALOX12B Antibody Resource


ALOX12B Antibody Resource
Gene Full Name: 
arachidonate 12-lipoxygenase, 12R type
Uniprot: 
O75342
Protein Name: 
arachidonate 12-lipoxygenase, 12R-type
Nucleotide: 
NM_001139
Alias: 
ARCI2;12R-LOX;
Ensembl: 
ENSG00000179477
Location: 
17p13.1
HPRD: 
04772
NCBI Gene: 
242
MIM: 
603741

Summary: 
This gene encodes an enzyme involved in the converstion of arachidonic acid to 12R-hydroxyeicosatetraenoic acid. Mutations in this gene are associated with nonbullous congenital ichthyosiform erythroderma. [provided by RefSeq, Jul 2008]
Function: 
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12R)-hydroperoxyeicosatetraenoic acid/(12R)-HPETE and minor stereoisomers. In the skin, acts upstream of ALOXE3 on the lineolate moiety of esterified omega-hydroxyacyl-sphingosine (EOS) ceramides to produce an epoxy-ketone derivative, a crucial step in the conjugation of omega-hydroxyceramide to membrane proteins. Therefore plays a crucial role in the synthesis of corneocytes lipid envelope and the establishment of the skin barrier to water loss. May also play a role in the regulation of the expression of airway mucins.
Subcellular location: 
Cytoplasm.
PTM: 
Disease: 
Ichthyosis, congenital, autosomal recessive 2 (ARCI2) [MIM:242100]: A form of autosomal recessive congenital ichthyosis, a disorder of keratinization with abnormal differentiation and desquamation of the epidermis, resulting in abnormal skin scaling over the whole body. The main skin phenotypes are lamellar ichthyosis (LI) and non-bullous congenital ichthyosiform erythroderma (NCIE), although phenotypic overlap within the same patient or among patients from the same family can occur. Lamellar ichthyosis is a condition often associated with an embedment in a collodion-like membrane at birth; skin scales later develop, covering the entire body surface. Non-bullous congenital ichthyosiform erythroderma characterized by fine whitish scaling on an erythrodermal background; larger brownish scales are present on the buttocks, neck and legs. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB00105 ALOX12B antibody - C-terminal region (OAAB00105) Human WB, IHC, ELISA 400ul $289 Details

Show all ALOX12B antibodies


Product Images
ALOX12B antibody - C-terminal region (OAAB00105) in A549 cells using Western Blot

Sample Type: A549

ALOX12B antibody - C-terminal region (OAAB00105) in  cells using Immunohistochemistry

ALOX12B Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP41919 African clawed frog ALOX12B antibody; Xenopus laevis ALOX12B antibody Q5FWK8 83.0%
ARP41918 African elephant ALOX12B antibody; Loxodonta africana ALOX12B antibody G3TM26 91.0%
ARP41918 Bovine ALOX12B antibody; Bos taurus ALOX12B antibody F1MXD8 85.0%
ARP41918 Cat ALOX12B antibody; Felis catus ALOX12B antibody M3WM43 85.0%
ARP41918 Chimpanzee ALOX12B antibody; Pan troglodytes ALOX12B antibody H2QC68 85.0%
ARP41918 Dog ALOX12B antibody; Canis familiaris ALOX12B antibody E2RS35 85.0%
ARP41918 European domestic ferret ALOX12B antibody; Mustela putorius furo ALOX12B antibody M3YA17 85.0%
ARP41918 Giant panda ALOX12B antibody; Ailuropoda melanoleuca ALOX12B antibody G1L7R4 85.0%
ARP41918 Giant panda ALOX12B antibody; Ailuropoda melanoleuca ALOX12B antibody G1L7R9 85.0%
ARP41918 Gray short-tailed opossum ALOX12B antibody; Monodelphis domestica ALOX12B antibody F7FZA5 85.0%
ARP41918 Guinea pig ALOX12B antibody; Cavia porcellus ALOX12B antibody H0VMH7 85.0%
ARP41918 Horse ALOX12B antibody; Equus caballus ALOX12B antibody F6PXL3 85.0%
ARP41918 Human ALOX12B antibody; Homo sapiens ALOX12B antibody O75342 85.0%
ARP41918 Little brown bat ALOX12B antibody; Myotis lucifugus ALOX12B antibody G1PAF4 85.0%
ARP41918 Northern white-cheeked gibbon ALOX12B antibody; Nomascus leucogenys ALOX12B antibody G1RFH9 85.0%
ARP41918 Pig ALOX12B antibody; Sus scrofa ALOX12B antibody F1SSY8 85.0%
ARP41918 Rabbit ALOX12B antibody; Oryctolagus cuniculus ALOX12B antibody G1TMI8 85.0%
ARP41918 Rat ALOX12B antibody; Rattus norvegicus ALOX12B antibody Q2KMM4 85.0%
ARP41918 Small-eared galago ALOX12B antibody; Otolemur garnettii ALOX12B antibody H0WJQ7 85.0%
ARP41918 Thirteen-lined ground squirrel ALOX12B antibody; Spermophilus tridecemlineatus ALOX12B antibody I3N9S9 91.0%
ARP41919 Western clawed frog ALOX12B antibody; Xenopus tropicalis ALOX12B antibody F6XZP5 91.0%
ARP41919 Western clawed frog ALOX12B antibody; Xenopus tropicalis ALOX12B antibody Q5FW07 83.0%
ARP41918 White-tufted-ear marmoset ALOX12B antibody; Callithrix jacchus ALOX12B antibody F7GI27 85.0%
ARP41918 White-tufted-ear marmoset ALOX12B antibody; Callithrix jacchus ALOX12B antibody F7IKS1 85.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207381_at721_B_lymphoblasts5.5004.320Details
BioGPS Gene Atlas207381_atAdipocyte4.2004.320Details
BioGPS Gene Atlas207381_atAdrenalCortex4.6004.320Details
BioGPS Gene Atlas207381_atAdrenalgland3.6004.320Details
BioGPS Gene Atlas207381_atAmygdala4.3504.320Details
BioGPS Gene Atlas207381_atAppendix4.3004.320Details
BioGPS Gene Atlas207381_atAtrioventricularNode3.3504.320Details
BioGPS Gene Atlas207381_atBDCA4+_DentriticCells4.5504.320Details
BioGPS Gene Atlas207381_atBonemarrow4.2504.320Details
BioGPS Gene Atlas207381_atBronchialEpithelialCells4.2004.320Details
BioGPS Gene Atlas207381_atCD105+_Endothelial4.2504.320Details
BioGPS Gene Atlas207381_atCD14+_Monocytes4.4504.320Details
BioGPS Gene Atlas207381_atCD19+_BCells(neg._sel.)4.5504.320Details
BioGPS Gene Atlas207381_atCD33+_Myeloid5.4504.320Details
BioGPS Gene Atlas207381_atCD34+5.3504.320Details
BioGPS Gene Atlas207381_atCD4+_Tcells4.5504.320Details
BioGPS Gene Atlas207381_atCD56+_NKCells4.9504.320Details
BioGPS Gene Atlas207381_atCD71+_EarlyErythroid4.0004.320Details
BioGPS Gene Atlas207381_atCD8+_Tcells4.0504.320Details
BioGPS Gene Atlas207381_atCardiacMyocytes5.6504.320Details
BioGPS Gene Atlas207381_atCaudatenucleus3.8004.320Details
BioGPS Gene Atlas207381_atCerebellum3.4504.320Details
BioGPS Gene Atlas207381_atCerebellumPeduncles4.8004.320Details
BioGPS Gene Atlas207381_atCiliaryGanglion3.1004.320Details
BioGPS Gene Atlas207381_atCingulateCortex4.3504.320Details
BioGPS Gene Atlas207381_atColorectaladenocarcinoma4.2504.320Details
BioGPS Gene Atlas207381_atDorsalRootGanglion3.3504.320Details
BioGPS Gene Atlas207381_atFetalThyroid4.1004.320Details
BioGPS Gene Atlas207381_atFetalbrain4.2504.320Details
BioGPS Gene Atlas207381_atFetalliver3.7004.320Details
BioGPS Gene Atlas207381_atFetallung3.4504.320Details
BioGPS Gene Atlas207381_atGlobusPallidus3.2004.320Details
BioGPS Gene Atlas207381_atHeart5.5004.320Details
BioGPS Gene Atlas207381_atHypothalamus4.6004.320Details
BioGPS Gene Atlas207381_atKidney3.5004.320Details
BioGPS Gene Atlas207381_atLeukemia_chronicMyelogenousK-5623.8504.320Details
BioGPS Gene Atlas207381_atLeukemia_promyelocytic-HL-603.7504.320Details
BioGPS Gene Atlas207381_atLeukemialymphoblastic(MOLT-4)3.4504.320Details
BioGPS Gene Atlas207381_atLiver5.7004.320Details
BioGPS Gene Atlas207381_atLung4.6504.320Details
BioGPS Gene Atlas207381_atLymphnode3.6004.320Details
BioGPS Gene Atlas207381_atLymphoma_burkitts(Daudi)5.4004.320Details
BioGPS Gene Atlas207381_atLymphoma_burkitts(Raji)6.0004.320Details
BioGPS Gene Atlas207381_atMedullaOblongata3.9004.320Details
BioGPS Gene Atlas207381_atOccipitalLobe3.8004.320Details
BioGPS Gene Atlas207381_atOlfactoryBulb3.3504.320Details
BioGPS Gene Atlas207381_atOvary2.8004.320Details
BioGPS Gene Atlas207381_atPancreas3.4004.320Details
BioGPS Gene Atlas207381_atPancreaticIslet4.5004.320Details
BioGPS Gene Atlas207381_atParietalLobe4.5004.320Details
BioGPS Gene Atlas207381_atPituitary4.9504.320Details
BioGPS Gene Atlas207381_atPlacenta4.3504.320Details
BioGPS Gene Atlas207381_atPons4.0004.320Details
BioGPS Gene Atlas207381_atPrefrontalCortex5.2504.320Details
BioGPS Gene Atlas207381_atProstate4.9504.320Details
BioGPS Gene Atlas207381_atSalivarygland3.4004.320Details
BioGPS Gene Atlas207381_atSkeletalMuscle5.0504.320Details
BioGPS Gene Atlas207381_atSkin3.5504.320Details
BioGPS Gene Atlas207381_atSmoothMuscle4.8004.320Details
BioGPS Gene Atlas207381_atSpinalcord4.5504.320Details
BioGPS Gene Atlas207381_atSubthalamicNucleus3.9004.320Details
BioGPS Gene Atlas207381_atSuperiorCervicalGanglion5.0004.320Details
BioGPS Gene Atlas207381_atTemporalLobe3.9004.320Details
BioGPS Gene Atlas207381_atTestis3.6504.320Details
BioGPS Gene Atlas207381_atTestisGermCell3.6004.320Details
BioGPS Gene Atlas207381_atTestisIntersitial3.5504.320Details
BioGPS Gene Atlas207381_atTestisLeydigCell4.2004.320Details
BioGPS Gene Atlas207381_atTestisSeminiferousTubule3.6004.320Details
BioGPS Gene Atlas207381_atThalamus4.3504.320Details
BioGPS Gene Atlas207381_atThymus3.3504.320Details
BioGPS Gene Atlas207381_atThyroid5.2504.320Details
BioGPS Gene Atlas207381_atTongue4.2504.320Details
BioGPS Gene Atlas207381_atTonsil6.1004.320Details
BioGPS Gene Atlas207381_atTrachea3.5504.320Details
BioGPS Gene Atlas207381_atTrigeminalGanglion4.4004.320Details
BioGPS Gene Atlas207381_atUterus3.4004.320Details
BioGPS Gene Atlas207381_atUterusCorpus3.8004.320Details
BioGPS Gene Atlas207381_atWholeBlood4.6504.320Details
BioGPS Gene Atlas207381_atWholebrain3.5504.320Details
BioGPS Gene Atlas207381_atcolon4.2504.320Details
BioGPS Gene Atlas207381_atpineal_day5.2804.320Details
BioGPS Gene Atlas207381_atpineal_night5.1804.320Details
BioGPS Gene Atlas207381_atretina5.1254.320Details
BioGPS Gene Atlas207381_atsmall_intestine4.1004.320Details
BioGPS NCI60207381_at7864.3914.330Details
BioGPS NCI60207381_atA1724.0814.330Details
BioGPS NCI60207381_atA2044.2794.330Details
BioGPS NCI60207381_atA3614.3574.330Details
BioGPS NCI60207381_atA4984.3124.330Details
BioGPS NCI60207381_atA5494.3734.330Details
BioGPS NCI60207381_atACC34.5194.330Details
BioGPS NCI60207381_atACHN4.0644.330Details
BioGPS NCI60207381_atALVA314.6554.330Details
BioGPS NCI60207381_atCAKI14.5084.330Details
BioGPS NCI60207381_atCCRT CEM4.8894.330Details
BioGPS NCI60207381_atCOLO2054.3564.330Details
BioGPS NCI60207381_atDLD14.2764.330Details
BioGPS NCI60207381_atDU1454.1294.330Details
BioGPS NCI60207381_atEKVX4.1704.330Details
BioGPS NCI60207381_atGM1334.4144.330Details
BioGPS NCI60207381_atGM16004.5224.330Details
BioGPS NCI60207381_atGM23134.3784.330Details
BioGPS NCI60207381_atGM23454.3314.330Details
BioGPS NCI60207381_atGM24934.5724.330Details
BioGPS NCI60207381_atGM974.9034.330Details
BioGPS NCI60207381_atHCC29983.9854.330Details
BioGPS NCI60207381_atHCT1164.3134.330Details
BioGPS NCI60207381_atHCT154.1584.330Details
BioGPS NCI60207381_atHEK 293 T-rex4.3884.330Details
BioGPS NCI60207381_atHEK 293T4.3224.330Details
BioGPS NCI60207381_atHEK2934.3274.330Details
BioGPS NCI60207381_atHELA4.1714.330Details
BioGPS NCI60207381_atHEPG24.2954.330Details
BioGPS NCI60207381_atHL604.4494.330Details
BioGPS NCI60207381_atHOP624.3204.330Details
BioGPS NCI60207381_atHOP924.2574.330Details
BioGPS NCI60207381_atHS578T4.2804.330Details
BioGPS NCI60207381_atHSG4.2324.330Details
BioGPS NCI60207381_atHT10804.2834.330Details
BioGPS NCI60207381_atHT294.6184.330Details
BioGPS NCI60207381_atIGROV14.2664.330Details
BioGPS NCI60207381_atIOSE804.2994.330Details
BioGPS NCI60207381_atJURKAT4.3024.330Details
BioGPS NCI60207381_atK5624.4824.330Details
BioGPS NCI60207381_atKM124.5074.330Details
BioGPS NCI60207381_atLN184.0864.330Details
BioGPS NCI60207381_atLNCAP4.3144.330Details
BioGPS NCI60207381_atLOX IMVI4.3074.330Details
BioGPS NCI60207381_atM144.2654.330Details
BioGPS NCI60207381_atMALME 3M4.6214.330Details
BioGPS NCI60207381_atMCF74.1654.330Details
BioGPS NCI60207381_atMD MB2314.3354.330Details
BioGPS NCI60207381_atMDA MB4354.6644.330Details
BioGPS NCI60207381_atMOLT44.4624.330Details
BioGPS NCI60207381_atNCI 4604.3934.330Details
BioGPS NCI60207381_atNCI H2264.3854.330Details
BioGPS NCI60207381_atNCI H234.3194.330Details
BioGPS NCI60207381_atNCI H322M4.3134.330Details
BioGPS NCI60207381_atNCVADR RES4.1944.330Details
BioGPS NCI60207381_atOVCAR34.5404.330Details
BioGPS NCI60207381_atOVCAR44.2994.330Details
BioGPS NCI60207381_atOVCAR54.2504.330Details
BioGPS NCI60207381_atOVCAR84.0724.330Details
BioGPS NCI60207381_atPANC14.3884.330Details
BioGPS NCI60207381_atRL74.3954.330Details
BioGPS NCI60207381_atRPMI 82264.3894.330Details
BioGPS NCI60207381_atRS118464.5704.330Details
BioGPS NCI60207381_atRXF3934.2854.330Details
BioGPS NCI60207381_atSAOS24.3404.330Details
BioGPS NCI60207381_atSF2684.3034.330Details
BioGPS NCI60207381_atSF2954.2514.330Details
BioGPS NCI60207381_atSF5394.1624.330Details
BioGPS NCI60207381_atSHSYSY+RA4.1964.330Details
BioGPS NCI60207381_atSHSYSY-RA4.2714.330Details
BioGPS NCI60207381_atSKMEL24.2974.330Details
BioGPS NCI60207381_atSKMEL284.3084.330Details
BioGPS NCI60207381_atSKMEL54.2304.330Details
BioGPS NCI60207381_atSKOV34.4864.330Details
BioGPS NCI60207381_atSN12C4.2764.330Details
BioGPS NCI60207381_atSNB194.0624.330Details
BioGPS NCI60207381_atSNB754.2894.330Details
BioGPS NCI60207381_atSR4.4364.330Details
BioGPS NCI60207381_atSW6204.3944.330Details
BioGPS NCI60207381_atT244.3624.330Details
BioGPS NCI60207381_atT3M44.5174.330Details
BioGPS NCI60207381_atTK104.3014.330Details
BioGPS NCI60207381_atU1184.2124.330Details
BioGPS NCI60207381_atU1384.0644.330Details
BioGPS NCI60207381_atU20S4.1804.330Details
BioGPS NCI60207381_atU2514.2524.330Details
BioGPS NCI60207381_atU874.1754.330Details
BioGPS NCI60207381_atUACC2574.2564.330Details
BioGPS NCI60207381_atUACC624.3654.330Details
BioGPS NCI60207381_atUO314.1604.330Details
BioGPS NCI60207381_atZR75_14.4504.330Details
BioGPS NCI60207381_atastrocytes4.3144.330Details
BioGPS NCI60207381_athuh-74.4404.330Details