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Gene ID: 239 | ALOX12 Antibody Resource


ALOX12 Antibody Resource
Gene Full Name: 
arachidonate 12-lipoxygenase
Uniprot: 
P18054
Protein Name: 
arachidonate 12-lipoxygenase, 12S-type
Nucleotide: 
NM_000697
Alias: 
LOG12;12-LOX;12S-LOX;
Ensembl: 
ENSG00000108839
Location: 
17p13.1
HPRD: 
01066
NCBI Gene: 
239
MIM: 
152391

Summary: 
Function: 
Non-heme iron-containing dioxygenase that catalyzes the stereo-specific peroxidation of free and esterified polyunsaturated fatty acids generating a spectrum of bioactive lipid mediators. Mainly converts arachidonic acid to (12S)-hydroperoxyeicosatetraenoic acid/(12S)-HPETE but can also metabolize linoleic acid. Has a dual activity since it also converts leukotriene A4/LTA4 into both the bioactive lipoxin A4/LXA4 and lipoxin B4/LXB4. Through the production of specific bioactive lipids like (12S)-HPETE it regulates different biological processes including platelet activation. It also probably positively regulates angiogenesis through regulation of the expression of the vascular endothelial growth factor. Plays a role in apoptotic process, promoting the survival of vascular smooth muscle cells for instance. May also play a role in the control of cell migration and proliferation.
Subcellular location: 
Cytoplasm › cytosol. Membrane. Note: Membrane association is stimulated by EGF.
PTM: 
Disease: 
Esophageal cancer (ESCR) [MIM:133239]: A malignancy of the esophagus. The most common types are esophageal squamous cell carcinoma and adenocarcinoma. Cancer of the esophagus remains a devastating disease because it is usually not detected until it has progressed to an advanced incurable stage. Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to esophageal cancer ().Colorectal cancer (CRC) [MIM:114500]: A complex disease characterized by malignant lesions arising from the inner wall of the large intestine (the colon) and the rectum. Genetic alterations are often associated with progression from premalignant lesion (adenoma) to invasive adenocarcinoma. Risk factors for cancer of the colon and rectum include colon polyps, long-standing ulcerative colitis, and genetic family history. Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Gln at position 261 may confer interindividual susceptibility to colorectal cancer ().
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP54350_P050 ALOX12 antibody - C-terminal region (ARP54350_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Mouse, Rabbit, Rat WB 50ug $289 Details
Polyclonal Antibody OAAB05474 ALOX12 antibody - C-terminal region (OAAB05474) Human WB, IHC, FC, ELISA 400ul $289 Details
Polyclonal Antibody ARP54349_P050 ALOX12 Antibody (ARP54349_P050) Polyclonal Bovine, Dog, Guinea pig, Horse, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details

Show all ALOX12 antibodies


Product Images
ALOX12 antibody - C-terminal region (ARP54350_P050) in Human Brain cells using Western Blot

Sample Type: Human Brain

ALOX12 antibody - C-terminal region (OAAB05474) in Human Skin cells using Immunohistochemistry

Sample Type: Human Skin

ALOX12 antibody - C-terminal region (OAAB05474) in K562 cells using Western Blot

Sample Type: K562

ALOX12 antibody - C-terminal region (OAAB05474) in k562 cells using Flow Cytometry

Sample Type: k562


ALOX12 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP54350 African elephant ALOX12 antibody; Loxodonta africana ALOX12 antibody G3SUT9 79.0%
ARP54350 Bovine ALOX12 antibody; Bos taurus ALOX12 antibody F1MFA8 86.0%
ARP54349 Cat ALOX12 antibody; Felis catus ALOX12 antibody M3VWH8 92.0%
ARP54350 Cat ALOX12 antibody; Felis catus ALOX12 antibody M3VWH8 86.0%
ARP54349 Chimpanzee ALOX12 antibody; Pan troglodytes ALOX12 antibody H2QC17 100.0%
ARP54350 Chimpanzee ALOX12 antibody; Pan troglodytes ALOX12 antibody H2QC17 100.0%
ARP54349 Dog ALOX12 antibody; Canis familiaris ALOX12 antibody E2R6Y3 92.0%
ARP54349 Dog ALOX12 antibody; Canis familiaris ALOX12 antibody F6Y0A9 92.0%
ARP54350 Dog ALOX12 antibody; Canis familiaris ALOX12 antibody E2R6Y3 86.0%
ARP54350 Dog ALOX12 antibody; Canis familiaris ALOX12 antibody F6Y0A9 86.0%
ARP54349 European domestic ferret ALOX12 antibody; Mustela putorius furo ALOX12 antibody M3YGZ9 92.0%
ARP54350 European domestic ferret ALOX12 antibody; Mustela putorius furo ALOX12 antibody M3YGZ9 86.0%
ARP54349 Giant panda ALOX12 antibody; Ailuropoda melanoleuca ALOX12 antibody D2HPT6 92.0%
ARP54350 Giant panda ALOX12 antibody; Ailuropoda melanoleuca ALOX12 antibody D2HPT6 86.0%
ARP54349 Horse ALOX12 antibody; Equus caballus ALOX12 antibody F6X3M3 93.0%
ARP54350 Horse ALOX12 antibody; Equus caballus ALOX12 antibody F6X3M3 93.0%
ARP54349 Human ALOX12 antibody; Homo sapiens ALOX12 antibody K7ENN9 100.0%
ARP54349 Human ALOX12 antibody; Homo sapiens ALOX12 antibody P18054 100.0%
ARP54350 Human ALOX12 antibody; Homo sapiens ALOX12 antibody P18054 100.0%
ARP54349 Mouse ALOX12 antibody; Mus musculus ALOX12 antibody A2CF85 86.0%
ARP54349 Mouse ALOX12 antibody; Mus musculus ALOX12 antibody P39655 86.0%
ARP54349 Mouse ALOX12 antibody; Mus musculus ALOX12 antibody Q3T9I9 86.0%
ARP54349 Mouse ALOX12 antibody; Mus musculus ALOX12 antibody Q3T9Y3 86.0%
ARP54349 Mouse ALOX12 antibody; Mus musculus ALOX12 antibody Q8C587 86.0%
ARP54349 Pig ALOX12 antibody; Sus scrofa ALOX12 antibody F1RF49 86.0%
ARP54350 Pig ALOX12 antibody; Sus scrofa ALOX12 antibody F1RF49 79.0%
ARP54349 Rabbit ALOX12 antibody; Oryctolagus cuniculus ALOX12 antibody G1U492 79.0%
ARP54350 Rabbit ALOX12 antibody; Oryctolagus cuniculus ALOX12 antibody G1U492 79.0%
ARP54349 Rat ALOX12 antibody; Rattus norvegicus ALOX12 antibody B4F796 93.0%
ARP54349 Rat ALOX12 antibody; Rattus norvegicus ALOX12 antibody F1LQ70 93.0%
ARP54350 Rat ALOX12 antibody; Rattus norvegicus ALOX12 antibody F1LQ70 79.0%
ARP54349 Rhesus macaque ALOX12 antibody; Macaca mulatta ALOX12 antibody F7GAZ2 100.0%
ARP54350 Rhesus macaque ALOX12 antibody; Macaca mulatta ALOX12 antibody F7GAZ2 100.0%
ARP54349 Small-eared galago ALOX12 antibody; Otolemur garnettii ALOX12 antibody H0WPR2 93.0%
ARP54350 Small-eared galago ALOX12 antibody; Otolemur garnettii ALOX12 antibody H0WPR2 79.0%
ARP54350 Sumatran orangutan ALOX12 antibody; Pongo abelii ALOX12 antibody H2NSF9 100.0%
ARP54349 Thirteen-lined ground squirrel ALOX12 antibody; Spermophilus tridecemlineatus ALOX12 antibody I3M7P8 93.0%
ARP54349 White-tufted-ear marmoset ALOX12 antibody; Callithrix jacchus ALOX12 antibody F7G9X7 100.0%
ARP54350 White-tufted-ear marmoset ALOX12 antibody; Callithrix jacchus ALOX12 antibody F7G9X7 100.0%
ARP54349 White-tufted-ear marmoset ALOX12 antibody; Callithrix jacchus ALOX12 antibody F7IM53 100.0%
ARP54350 White-tufted-ear marmoset ALOX12 antibody; Callithrix jacchus ALOX12 antibody F7IM53 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207206_s_at721_B_lymphoblasts4.7004.250Details
BioGPS Gene Atlas207206_s_atAdipocyte3.7504.250Details
BioGPS Gene Atlas207206_s_atAdrenalCortex4.0004.250Details
BioGPS Gene Atlas207206_s_atAdrenalgland3.3504.250Details
BioGPS Gene Atlas207206_s_atAmygdala4.0004.250Details
BioGPS Gene Atlas207206_s_atAppendix4.2504.250Details
BioGPS Gene Atlas207206_s_atAtrioventricularNode3.2504.250Details
BioGPS Gene Atlas207206_s_atBDCA4+_DentriticCells4.1004.250Details
BioGPS Gene Atlas207206_s_atBonemarrow4.5504.250Details
BioGPS Gene Atlas207206_s_atBronchialEpithelialCells3.8004.250Details
BioGPS Gene Atlas207206_s_atCD105+_Endothelial3.8504.250Details
BioGPS Gene Atlas207206_s_atCD14+_Monocytes4.2504.250Details
BioGPS Gene Atlas207206_s_atCD19+_BCells(neg._sel.)4.0504.250Details
BioGPS Gene Atlas207206_s_atCD33+_Myeloid4.9004.250Details
BioGPS Gene Atlas207206_s_atCD34+4.9504.250Details
BioGPS Gene Atlas207206_s_atCD4+_Tcells4.1004.250Details
BioGPS Gene Atlas207206_s_atCD56+_NKCells4.6004.250Details
BioGPS Gene Atlas207206_s_atCD71+_EarlyErythroid3.5504.250Details
BioGPS Gene Atlas207206_s_atCD8+_Tcells3.6004.250Details
BioGPS Gene Atlas207206_s_atCardiacMyocytes4.8504.250Details
BioGPS Gene Atlas207206_s_atCaudatenucleus3.4504.250Details
BioGPS Gene Atlas207206_s_atCerebellum3.1004.250Details
BioGPS Gene Atlas207206_s_atCerebellumPeduncles4.4504.250Details
BioGPS Gene Atlas207206_s_atCiliaryGanglion2.7004.250Details
BioGPS Gene Atlas207206_s_atCingulateCortex3.9504.250Details
BioGPS Gene Atlas207206_s_atColorectaladenocarcinoma3.8004.250Details
BioGPS Gene Atlas207206_s_atDorsalRootGanglion2.9504.250Details
BioGPS Gene Atlas207206_s_atFetalThyroid3.7504.250Details
BioGPS Gene Atlas207206_s_atFetalbrain3.8504.250Details
BioGPS Gene Atlas207206_s_atFetalliver3.3504.250Details
BioGPS Gene Atlas207206_s_atFetallung3.2004.250Details
BioGPS Gene Atlas207206_s_atGlobusPallidus2.9004.250Details
BioGPS Gene Atlas207206_s_atHeart5.7004.250Details
BioGPS Gene Atlas207206_s_atHypothalamus4.1504.250Details
BioGPS Gene Atlas207206_s_atKidney3.2004.250Details
BioGPS Gene Atlas207206_s_atLeukemia_chronicMyelogenousK-5623.4504.250Details
BioGPS Gene Atlas207206_s_atLeukemia_promyelocytic-HL-603.4004.250Details
BioGPS Gene Atlas207206_s_atLeukemialymphoblastic(MOLT-4)3.1004.250Details
BioGPS Gene Atlas207206_s_atLiver5.2004.250Details
BioGPS Gene Atlas207206_s_atLung4.2504.250Details
BioGPS Gene Atlas207206_s_atLymphnode3.3004.250Details
BioGPS Gene Atlas207206_s_atLymphoma_burkitts(Daudi)4.9004.250Details
BioGPS Gene Atlas207206_s_atLymphoma_burkitts(Raji)5.3504.250Details
BioGPS Gene Atlas207206_s_atMedullaOblongata3.5004.250Details
BioGPS Gene Atlas207206_s_atOccipitalLobe3.4504.250Details
BioGPS Gene Atlas207206_s_atOlfactoryBulb3.0004.250Details
BioGPS Gene Atlas207206_s_atOvary2.7004.250Details
BioGPS Gene Atlas207206_s_atPancreas3.0504.250Details
BioGPS Gene Atlas207206_s_atPancreaticIslet4.1004.250Details
BioGPS Gene Atlas207206_s_atParietalLobe4.0504.250Details
BioGPS Gene Atlas207206_s_atPituitary4.4504.250Details
BioGPS Gene Atlas207206_s_atPlacenta3.9004.250Details
BioGPS Gene Atlas207206_s_atPons3.6504.250Details
BioGPS Gene Atlas207206_s_atPrefrontalCortex4.7504.250Details
BioGPS Gene Atlas207206_s_atProstate4.5004.250Details
BioGPS Gene Atlas207206_s_atSalivarygland3.1504.250Details
BioGPS Gene Atlas207206_s_atSkeletalMuscle4.4004.250Details
BioGPS Gene Atlas207206_s_atSkin3.1504.250Details
BioGPS Gene Atlas207206_s_atSmoothMuscle4.3504.250Details
BioGPS Gene Atlas207206_s_atSpinalcord4.1004.250Details
BioGPS Gene Atlas207206_s_atSubthalamicNucleus3.5504.250Details
BioGPS Gene Atlas207206_s_atSuperiorCervicalGanglion4.5004.250Details
BioGPS Gene Atlas207206_s_atTemporalLobe3.5004.250Details
BioGPS Gene Atlas207206_s_atTestis3.6504.250Details
BioGPS Gene Atlas207206_s_atTestisGermCell3.2504.250Details
BioGPS Gene Atlas207206_s_atTestisIntersitial3.2504.250Details
BioGPS Gene Atlas207206_s_atTestisLeydigCell3.7504.250Details
BioGPS Gene Atlas207206_s_atTestisSeminiferousTubule3.3004.250Details
BioGPS Gene Atlas207206_s_atThalamus3.9004.250Details
BioGPS Gene Atlas207206_s_atThymus3.0004.250Details
BioGPS Gene Atlas207206_s_atThyroid4.7504.250Details
BioGPS Gene Atlas207206_s_atTongue9.2004.250Details
BioGPS Gene Atlas207206_s_atTonsil3.7004.250Details
BioGPS Gene Atlas207206_s_atTrachea3.2004.250Details
BioGPS Gene Atlas207206_s_atTrigeminalGanglion3.8504.250Details
BioGPS Gene Atlas207206_s_atUterus3.1004.250Details
BioGPS Gene Atlas207206_s_atUterusCorpus3.4504.250Details
BioGPS Gene Atlas207206_s_atWholeBlood29.0504.250Details
BioGPS Gene Atlas207206_s_atWholebrain3.2504.250Details
BioGPS Gene Atlas207206_s_atcolon3.8504.250Details
BioGPS Gene Atlas207206_s_atpineal_day4.7604.250Details
BioGPS Gene Atlas207206_s_atpineal_night4.6804.250Details
BioGPS Gene Atlas207206_s_atretina4.6754.250Details
BioGPS Gene Atlas207206_s_atsmall_intestine3.7004.250Details
BioGPS NCI60207206_s_at7863.7463.820Details
BioGPS NCI60207206_s_atA1723.5373.820Details
BioGPS NCI60207206_s_atA2043.6393.820Details
BioGPS NCI60207206_s_atA3613.7553.820Details
BioGPS NCI60207206_s_atA4983.6473.820Details
BioGPS NCI60207206_s_atA5493.7323.820Details
BioGPS NCI60207206_s_atACC33.7993.820Details
BioGPS NCI60207206_s_atACHN3.4533.820Details
BioGPS NCI60207206_s_atALVA313.8463.820Details
BioGPS NCI60207206_s_atCAKI13.7683.820Details
BioGPS NCI60207206_s_atCCRT CEM3.9973.820Details
BioGPS NCI60207206_s_atCOLO2053.6863.820Details
BioGPS NCI60207206_s_atDLD13.5973.820Details
BioGPS NCI60207206_s_atDU1453.5173.820Details
BioGPS NCI60207206_s_atEKVX3.5723.820Details
BioGPS NCI60207206_s_atGM1333.7653.820Details
BioGPS NCI60207206_s_atGM16003.8073.820Details
BioGPS NCI60207206_s_atGM23133.7283.820Details
BioGPS NCI60207206_s_atGM23453.6813.820Details
BioGPS NCI60207206_s_atGM24933.8113.820Details
BioGPS NCI60207206_s_atGM974.0143.820Details
BioGPS NCI60207206_s_atHCC29983.3633.820Details
BioGPS NCI60207206_s_atHCT1163.6563.820Details
BioGPS NCI60207206_s_atHCT153.4813.820Details
BioGPS NCI60207206_s_atHEK 293 T-rex3.8003.820Details
BioGPS NCI60207206_s_atHEK 293T3.6663.820Details
BioGPS NCI60207206_s_atHEK2933.7253.820Details
BioGPS NCI60207206_s_atHELA3.5063.820Details
BioGPS NCI60207206_s_atHEPG23.6613.820Details
BioGPS NCI60207206_s_atHL603.8683.820Details
BioGPS NCI60207206_s_atHOP623.6743.820Details
BioGPS NCI60207206_s_atHOP923.5943.820Details
BioGPS NCI60207206_s_atHS578T3.6033.820Details
BioGPS NCI60207206_s_atHSG3.5883.820Details
BioGPS NCI60207206_s_atHT10803.6463.820Details
BioGPS NCI60207206_s_atHT293.8723.820Details
BioGPS NCI60207206_s_atIGROV13.6133.820Details
BioGPS NCI60207206_s_atIOSE803.6243.820Details
BioGPS NCI60207206_s_atJURKAT3.6673.820Details
BioGPS NCI60207206_s_atK5623.8653.820Details
BioGPS NCI60207206_s_atKM123.7763.820Details
BioGPS NCI60207206_s_atLN183.5303.820Details
BioGPS NCI60207206_s_atLNCAP3.6683.820Details
BioGPS NCI60207206_s_atLOX IMVI3.6613.820Details
BioGPS NCI60207206_s_atM143.6343.820Details
BioGPS NCI60207206_s_atMALME 3M3.8273.820Details
BioGPS NCI60207206_s_atMCF73.5483.820Details
BioGPS NCI60207206_s_atMD MB2313.6863.820Details
BioGPS NCI60207206_s_atMDA MB4353.8573.820Details
BioGPS NCI60207206_s_atMOLT43.7403.820Details
BioGPS NCI60207206_s_atNCI 4603.7533.820Details
BioGPS NCI60207206_s_atNCI H2263.7293.820Details
BioGPS NCI60207206_s_atNCI H233.6643.820Details
BioGPS NCI60207206_s_atNCI H322M3.6513.820Details
BioGPS NCI60207206_s_atNCVADR RES3.4953.820Details
BioGPS NCI60207206_s_atOVCAR33.7923.820Details
BioGPS NCI60207206_s_atOVCAR43.6543.820Details
BioGPS NCI60207206_s_atOVCAR53.6253.820Details
BioGPS NCI60207206_s_atOVCAR83.4573.820Details
BioGPS NCI60207206_s_atPANC13.7023.820Details
BioGPS NCI60207206_s_atRL73.7153.820Details
BioGPS NCI60207206_s_atRPMI 82263.7103.820Details
BioGPS NCI60207206_s_atRS118464.0193.820Details
BioGPS NCI60207206_s_atRXF3933.6543.820Details
BioGPS NCI60207206_s_atSAOS23.7133.820Details
BioGPS NCI60207206_s_atSF2683.6473.820Details
BioGPS NCI60207206_s_atSF2953.6223.820Details
BioGPS NCI60207206_s_atSF5393.4813.820Details
BioGPS NCI60207206_s_atSHSYSY+RA3.5893.820Details
BioGPS NCI60207206_s_atSHSYSY-RA3.6393.820Details
BioGPS NCI60207206_s_atSKMEL23.6613.820Details
BioGPS NCI60207206_s_atSKMEL283.6573.820Details
BioGPS NCI60207206_s_atSKMEL53.5883.820Details
BioGPS NCI60207206_s_atSKOV33.7683.820Details
BioGPS NCI60207206_s_atSN12C3.6533.820Details
BioGPS NCI60207206_s_atSNB193.4943.820Details
BioGPS NCI60207206_s_atSNB753.6343.820Details
BioGPS NCI60207206_s_atSR3.8283.820Details
BioGPS NCI60207206_s_atSW6203.6713.820Details
BioGPS NCI60207206_s_atT243.7583.820Details
BioGPS NCI60207206_s_atT3M418.8523.820Details
BioGPS NCI60207206_s_atTK103.6463.820Details
BioGPS NCI60207206_s_atU1183.6123.820Details
BioGPS NCI60207206_s_atU1383.5143.820Details
BioGPS NCI60207206_s_atU20S3.6223.820Details
BioGPS NCI60207206_s_atU2513.6053.820Details
BioGPS NCI60207206_s_atU873.5863.820Details
BioGPS NCI60207206_s_atUACC2573.5853.820Details
BioGPS NCI60207206_s_atUACC623.7033.820Details
BioGPS NCI60207206_s_atUO313.5553.820Details
BioGPS NCI60207206_s_atZR75_13.7433.820Details
BioGPS NCI60207206_s_atastrocytes3.7013.820Details
BioGPS NCI60207206_s_athuh-73.7993.820Details