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Gene ID: 221120 | ALKBH3 Antibody Resource


ALKBH3 Antibody Resource
Gene Full Name: 
alkB, alkylation repair homolog 3 (E. coli)
Uniprot: 
Q96Q83
Protein Name: 
alpha-ketoglutarate-dependent dioxygenase alkB homolog 3
Nucleotide: 
NM_139178
Alias: 
ABH3;PCA1;DEPC1;DEPC-1;
Ensembl: 
ENSG00000166199
Location: 
11p11.2
HPRD: 
16793
NCBI Gene: 
221120
MIM: 
610603

Summary: 
The Escherichia coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA. ALKBH2 (MIM 610602) and ALKBH3 are E. coli AlkB homologs that catalyze the removal of 1-methyladenine and 3-methylcytosine (Duncan et al., 2002 [PubMed 12486230]).[supplied by OMIM, Mar 2008]
Function: 
Dioxygenase that repairs alkylated DNA containing 1-methyladenine (1meA) and 3-methylcytosine (3meC) by oxidative demethylation. Has a strong preference for single-stranded DNA. Able to process alkylated 3mC within double-stranded regions via its interaction with ASCC3, which promotes DNA unwinding to generate single-stranded substrate needed for ALKHB3. May also act on RNA. Requires molecular oxygen, alpha-ketoglutarate and iron.
Subcellular location: 
Cytoplasm. Nucleus .
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP55429_P050 ALKBH3 antibody - middle region (ARP55429_P050) Polyclonal Dog, Guinea pig, Horse, Human, Mouse, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAAB05277 ALKBH3 antibody - C-terminal region (OAAB05277) Human; Mouse WB, IHC, ELISA 400ul $289 Details
Protein OOPA00115 ALKBH3 Human - Recombinant Human ALKB Alkylation Repair Homolog 3 (5ug) 5ug $100 Details

Show all ALKBH3 antibodies


Product Images
ALKBH3 antibody - middle region (ARP55429_P050) in Human Muscle cells using Western Blot

Sample Type: Human Muscle

ALKBH3 antibody - C-terminal region (OAAB05277) in human prostate carcinoma cells using Immunohistochemistry

Sample Type: human prostate carcinoma

ALKBH3 antibody - C-terminal region (OAAB05277) in Mouse Kidney cells using Western Blot

Sample Type: Mouse Kidney


ALKBH3 Protocols

Publications
Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP55429 African clawed frog ALKBH3 antibody; Xenopus laevis ALKBH3 antibody Q5PPV1 93.0%
ARP55429 Bovine ALKBH3 antibody; Bos taurus ALKBH3 antibody Q32L00 93.0%
ARP55429 Cat ALKBH3 antibody; Felis catus ALKBH3 antibody M3WWB8 93.0%
ARP55429 Chimpanzee ALKBH3 antibody; Pan troglodytes ALKBH3 antibody H2Q3G1 100.0%
ARP55429 Chinese softshell turtle ALKBH3 antibody; Pelodiscus sinensis ALKBH3 antibody K7FZ03 100.0%
ARP55429 Collared flycatcher ALKBH3 antibody; Ficedula albicollis ALKBH3 antibody U3KD04 93.0%
ARP55429 Dog ALKBH3 antibody; Canis familiaris ALKBH3 antibody E2QU58 93.0%
ARP55429 Dog ALKBH3 antibody; Canis familiaris ALKBH3 antibody F6UZ53 93.0%
ARP55429 Dog ALKBH3 antibody; Canis familiaris ALKBH3 antibody J9P9A4 93.0%
ARP55429 Domestic duck ALKBH3 antibody; Anas platyrhynchos ALKBH3 antibody U3IMF2 93.0%
ARP55429 Duckbill platypus ALKBH3 antibody; Ornithorhynchus anatinus ALKBH3 antibody F7G6X9 93.0%
ARP55429 Duckbill platypus ALKBH3 antibody; Ornithorhynchus anatinus ALKBH3 antibody F7GCA9 93.0%
ARP55429 European domestic ferret ALKBH3 antibody; Mustela putorius furo ALKBH3 antibody M3Y448 93.0%
ARP55429 Giant panda ALKBH3 antibody; Ailuropoda melanoleuca ALKBH3 antibody G1LDY0 93.0%
ARP55429 Horse ALKBH3 antibody; Equus caballus ALKBH3 antibody F7CHQ0 100.0%
ARP55429 Human ALKBH3 antibody; Homo sapiens ALKBH3 antibody H0YDH4 100.0%
ARP55429 Human ALKBH3 antibody; Homo sapiens ALKBH3 antibody Q96Q83 100.0%
ARP55429 Mouse ALKBH3 antibody; Mus musculus ALKBH3 antibody A2AKV6 100.0%
ARP55429 Mouse ALKBH3 antibody; Mus musculus ALKBH3 antibody Q8K1E6 100.0%
ARP55429 Pig ALKBH3 antibody; Sus scrofa ALKBH3 antibody I3L9I0 100.0%
ARP55429 Rabbit ALKBH3 antibody; Oryctolagus cuniculus ALKBH3 antibody G1TBG6 86.0%
ARP55429 Rat ALKBH3 antibody; Rattus norvegicus ALKBH3 antibody Q5XIC8 100.0%
ARP55429 Rhesus macaque ALKBH3 antibody; Macaca mulatta ALKBH3 antibody F7HUA6 100.0%
ARP55429 Rhesus macaque ALKBH3 antibody; Macaca mulatta ALKBH3 antibody H9EVC6 100.0%
ARP55429 Small-eared galago ALKBH3 antibody; Otolemur garnettii ALKBH3 antibody H0WZW5 100.0%
ARP55429 Spotted green pufferfish ALKBH3 antibody; Tetraodon nigroviridis ALKBH3 antibody H3CYF7 79.0%
ARP55429 Sumatran orangutan ALKBH3 antibody; Pongo abelii ALKBH3 antibody H2NDN1 100.0%
ARP55429 Tasmanian devil ALKBH3 antibody; Sarcophilus harrisii ALKBH3 antibody G3VVB7 93.0%
ARP55429 Thirteen-lined ground squirrel ALKBH3 antibody; Spermophilus tridecemlineatus ALKBH3 antibody I3M775 93.0%
ARP55429 Western clawed frog ALKBH3 antibody; Xenopus tropicalis ALKBH3 antibody F6S0W0 93.0%
ARP55429 White-tufted-ear marmoset ALKBH3 antibody; Callithrix jacchus ALKBH3 antibody F7IPG0 100.0%
ARP55429 Zebra finch ALKBH3 antibody; Taeniopygia guttata ALKBH3 antibody H0ZIY1 86.0%

Tissue & Cell Line Gene Expression Data