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Gene ID: 84335 | AKT1S1 Antibody Resource


AKT1S1 Antibody Resource
Gene Full Name: 
AKT1 substrate 1 (proline-rich)
Uniprot: 
Q96B36
Protein Name: 
proline-rich AKT1 substrate 1
Nucleotide: 
NM_001278160
Alias: 
Lobe;PRAS40;
Ensembl: 
ENSG00000204673
Location: 
19q13.33
HPRD: 
12441
NCBI Gene: 
84335
MIM: 
610221

Summary: 
AKT1S1 is a proline-rich substrate of AKT (MIM 164730) that binds 14-3-3 protein (see YWHAH, MIM 113508) when phosphorylated (Kovacina et al., 2003 [PubMed 12524439]).[supplied by OMIM, Mar 2008]
Function: 
Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection.
Subcellular location: 
Cytoplasm › cytosol. Note: Found in the cytosolic fraction of the brain .
PTM: 
Phosphoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP48061_P050 AKT1S1 antibody - C-terminal region (ARP48061_P050) Polyclonal Bovine, Dog, Guinea pig, Mouse, Pig, Rat WB 50ug $289 Details
Polyclonal Antibody ARP48062_P050 Akt1s1 Antibody - middle region (ARP48062_P050) Rat; Human WB 50ug $289 Details
Monoclonal Antibody OAAB06974 AKT1S1 antibody (Ascites) (OAAB06974) Human WB 0.1 ml $289 Details
Monoclonal Antibody OAAB06975 AKT1S1 antibody (OAAB06975) Human WB 400ul $289 Details
Polyclonal Antibody OAAB10574 AKT1S1 antibody - C - terminal region (OAAB10574) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAAF00753 AKT1S1 Antibody (OAAF00753) Polyclonal Human, Mouse, Rat WB, IHC, ELISA 100 ug $289 Details

Show all AKT1S1 antibodies


Product Images
AKT1S1 antibody - C-terminal region (ARP48061_P050) in Human 293T cells using Western Blot

Sample Type: Human 293T

Akt1s1 Antibody - middle region (ARP48062_P050) in Rat Thymus cells using Western Blot

Sample Type: Rat Thymus

AKT1S1 antibody (Ascites) (OAAB06974) in A375 cells using Western Blot

Sample Type: A375

AKT1S1 antibody (OAAB06975) in A375 cells using Western Blot

Sample Type: A375

AKT1S1 antibody - C - terminal region (OAAB10574) in Hela cells using Western Blot

Sample Type: Hela

AKT1S1 Antibody (OAAF00753) in 293 cells using Western Blot

Sample Type: 293

AKT1S1 Antibody (OAAF00753) in Human brain cells using Immunohistochemistry

Sample Type: Human brain


AKT1S1 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP48061 Bovine AKT1S1 antibody; Bos taurus AKT1S1 antibody A3KN52 100.0%
ARP48062 Bovine AKT1S1 antibody; Bos taurus AKT1S1 antibody A3KN52 100.0%
ARP48061 Bovine AKT1S1 antibody; Bos taurus AKT1S1 antibody F1N197 100.0%
ARP48062 Bovine AKT1S1 antibody; Bos taurus AKT1S1 antibody F1N197 100.0%
ARP48061 Chimpanzee AKT1S1 antibody; Pan troglodytes AKT1S1 antibody G2HDU5 100.0%
ARP48062 Chimpanzee AKT1S1 antibody; Pan troglodytes AKT1S1 antibody G2HDU5 100.0%
ARP48061 Chimpanzee AKT1S1 antibody; Pan troglodytes AKT1S1 antibody K7AMC0 100.0%
ARP48062 Chimpanzee AKT1S1 antibody; Pan troglodytes AKT1S1 antibody K7AMC0 100.0%
ARP48061 Dog AKT1S1 antibody; Canis familiaris AKT1S1 antibody E2R0X9 93.0%
ARP48062 Dog AKT1S1 antibody; Canis familiaris AKT1S1 antibody E2R0X9 86.0%
ARP48061 European domestic ferret AKT1S1 antibody; Mustela putorius furo AKT1S1 antibody M3XT83 100.0%
ARP48062 European domestic ferret AKT1S1 antibody; Mustela putorius furo AKT1S1 antibody M3XT83 100.0%
ARP48062 Gray short-tailed opossum AKT1S1 antibody; Monodelphis domestica AKT1S1 antibody F6T8V8 85.0%
ARP48061 Horse AKT1S1 antibody; Equus caballus AKT1S1 antibody F6U636 100.0%
ARP48062 Horse AKT1S1 antibody; Equus caballus AKT1S1 antibody F6U636 100.0%
ARP48061 Human AKT1S1 antibody; Homo sapiens AKT1S1 antibody Q96B36-2 100.0%
ARP48061 Human AKT1S1 antibody; Homo sapiens AKT1S1 antibody Q96B36-3 100.0%
ARP48062 Human AKT1S1 antibody; Homo sapiens AKT1S1 antibody Q96B36-3 100.0%
ARP48061 Human AKT1S1 antibody; Homo sapiens AKT1S1 antibody Q96B36 100.0%
ARP48062 Human AKT1S1 antibody; Homo sapiens AKT1S1 antibody Q96B36 100.0%
ARP48062 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody D3YWZ1 100.0%
ARP48062 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody D3Z4R0 100.0%
ARP48061 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody E9QKI4 100.0%
ARP48062 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody E9QKI4 100.0%
ARP48061 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody E9QKI5 100.0%
ARP48062 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody E9QKI5 100.0%
ARP48061 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody F6R8S6 100.0%
ARP48062 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody F6R8S6 100.0%
ARP48061 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody Q9D1F4 100.0%
ARP48062 Mouse AKT1S1 antibody; Mus musculus AKT1S1 antibody Q9D1F4 100.0%
ARP48061 Pig AKT1S1 antibody; Sus scrofa AKT1S1 antibody F1RHU2 100.0%
ARP48062 Pig AKT1S1 antibody; Sus scrofa AKT1S1 antibody F1RHU2 100.0%
ARP48061 Rat AKT1S1 antibody; Rattus norvegicus AKT1S1 antibody D3ZH75 100.0%
ARP48062 Rat AKT1S1 antibody; Rattus norvegicus AKT1S1 antibody D3ZH75 100.0%
ARP48061 Rhesus macaque AKT1S1 antibody; Macaca mulatta AKT1S1 antibody F6PK02 100.0%
ARP48062 Rhesus macaque AKT1S1 antibody; Macaca mulatta AKT1S1 antibody F6PK02 93.0%
ARP48061 Small-eared galago AKT1S1 antibody; Otolemur garnettii AKT1S1 antibody H0WRT4 100.0%
ARP48062 Small-eared galago AKT1S1 antibody; Otolemur garnettii AKT1S1 antibody H0WRT4 100.0%
ARP48061 Sumatran orangutan AKT1S1 antibody; Pongo abelii AKT1S1 antibody H2NZQ0 100.0%
ARP48062 Sumatran orangutan AKT1S1 antibody; Pongo abelii AKT1S1 antibody H2NZQ0 100.0%
ARP48061 Thirteen-lined ground squirrel AKT1S1 antibody; Spermophilus tridecemlineatus AKT1S1 antibody I3MJT1 100.0%
ARP48062 Thirteen-lined ground squirrel AKT1S1 antibody; Spermophilus tridecemlineatus AKT1S1 antibody I3MJT1 93.0%
ARP48061 White-tufted-ear marmoset AKT1S1 antibody; Callithrix jacchus AKT1S1 antibody F6RUS2 100.0%
ARP48062 White-tufted-ear marmoset AKT1S1 antibody; Callithrix jacchus AKT1S1 antibody F6RUS2 100.0%
ARP48061 White-tufted-ear marmoset AKT1S1 antibody; Callithrix jacchus AKT1S1 antibody F6ZIL1 100.0%
ARP48062 White-tufted-ear marmoset AKT1S1 antibody; Callithrix jacchus AKT1S1 antibody F6ZIL1 100.0%

Tissue & Cell Line Gene Expression Data