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Gene ID: 9447 | AIM2 Antibody Resource


AIM2 Antibody Resource
Gene Full Name: 
absent in melanoma 2
Uniprot: 
O14862
Protein Name: 
interferon-inducible protein AIM2
Nucleotide: 
XR_241108
Alias: 
PYHIN4;
Ensembl: 
ENSG00000163568
Location: 
1q22
HPRD: 
05202
NCBI Gene: 
9447
MIM: 
604578

Summary: 
AIM2 is a member of the IFI20X /IFI16 family. It plays a putative role in tumorigenic reversion and may control cell proliferation. Interferon-gamma induces expression of AIM2. [provided by RefSeq, Jul 2008]
Function: 
Involved in innate immune response by recognizing cytosolic double-stranded DNA and inducing caspase-1-activating inflammasome formation in macrophages. Upon binding to DNA is thought to undergo oligomerization and to associate with PYCARD initiating the recruitment of caspase-1 precusrsor and processing of interleukin-1 beta and interleukin-18. Detects cytosolic dsDNA of viral and bacterial origin in a non-sequence-specific manner. Can also trigger PYCARD-dependent, caspase-1-independent cell death that involves caspase-8 . Tumor suppressor which may act by repressing NF-kappa-B transcriptional activity.
Subcellular location: 
Nucleus. Cytoplasm. Note: Activated inflammasomes can aggregate in the cytosol as speck-like particles.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP50505_P050 AIM2 antibody - N-terminal region (ARP50505_P050) Polyclonal Horse, Human, Mouse WB 50ug $289 Details
Polyclonal Antibody OAEB01074 AIM2 Antibody (OAEB01074) Human WB, IHC 0.1mg $289 Details
Polyclonal Antibody OAAB06476 AIM2 antibody - N-terminal region (OAAB06476) Human WB, FC, ELISA 400ul $289 Details
Polyclonal Antibody ARP50506_P050 AIM2 Antibody (ARP50506_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody OAAF02825 AIM2 Antibody (OAAF02825) Polyclonal Human WB, ELISA 100 ug $289 Details

Show all AIM2 antibodies


Product Images
AIM2 antibody - N-terminal region (ARP50505_P050) in Human Lung cells using Western Blot

Sample Type: Human Lung

AIM2 antibody - N-terminal region (OAAB06476) in MCF-7 cells using Flow Cytometry

Sample Type: MCF-7

AIM2 antibody - N-terminal region (OAAB06476) in MCF-7, HL-60, K562, Hela cells using Western Blot

Sample Type: MCF-7, HL-60, K562, Hela

AIM2 Antibody (OAAF02825) in HUVEC cells using Western Blot

Sample Type: HUVEC

AIM2 Antibody (OAEB01074) in Human spleen cells using Immunohistochemistry

Sample Type: Human spleen

AIM2 Antibody (OAEB01074) in IFNbeta-treated WI-38 cells using Western Blot

Sample Type: IFNbeta-treated WI-38


AIM2 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP50505 Chimpanzee AIM2 antibody; Pan troglodytes AIM2 antibody H2R8J4 100.0%
ARP50506 Chimpanzee AIM2 antibody; Pan troglodytes AIM2 antibody H2R8J4 100.0%
ARP50505 Horse AIM2 antibody; Equus caballus AIM2 antibody F7CDF7 100.0%
ARP50506 Horse AIM2 antibody; Equus caballus AIM2 antibody F7CDF7 83.0%
ARP50505 Human AIM2 antibody; Homo sapiens AIM2 antibody O14862 100.0%
ARP50506 Human AIM2 antibody; Homo sapiens AIM2 antibody O14862 100.0%
ARP50505 Human AIM2 antibody; Homo sapiens AIM2 antibody Q5T3V8 100.0%
ARP50505 Mouse AIM2 antibody; Mus musculus AIM2 antibody D3Z341 79.0%
ARP50505 Mouse AIM2 antibody; Mus musculus AIM2 antibody G3UZ36 79.0%
ARP50505 Mouse AIM2 antibody; Mus musculus AIM2 antibody I3QI32 79.0%
ARP50505 Mouse AIM2 antibody; Mus musculus AIM2 antibody Q91VJ1 79.0%
ARP50505 Northern white-cheeked gibbon AIM2 antibody; Nomascus leucogenys AIM2 antibody G1RRV2 100.0%
ARP50506 Northern white-cheeked gibbon AIM2 antibody; Nomascus leucogenys AIM2 antibody G1RRV2 100.0%
ARP50505 Rat AIM2 antibody; Rattus norvegicus AIM2 antibody D4A9W0 79.0%
ARP50505 Rat AIM2 antibody; Rattus norvegicus AIM2 antibody M0R7W9 79.0%
ARP50505 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody F7GG15 100.0%
ARP50505 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody F7GG22 100.0%
ARP50505 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody H9F2D7 100.0%
ARP50505 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody H9YYG9 100.0%
ARP50506 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody F7GG15 93.0%
ARP50506 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody F7GG22 93.0%
ARP50506 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody H9F2D7 86.0%
ARP50506 Rhesus macaque AIM2 antibody; Macaca mulatta AIM2 antibody H9YYG9 86.0%
ARP50505 Small-eared galago AIM2 antibody; Otolemur garnettii AIM2 antibody H0WG24 86.0%
ARP50505 Sumatran orangutan AIM2 antibody; Pongo abelii AIM2 antibody H2N578 100.0%
ARP50506 Sumatran orangutan AIM2 antibody; Pongo abelii AIM2 antibody H2N578 100.0%
ARP50505 Thirteen-lined ground squirrel AIM2 antibody; Spermophilus tridecemlineatus AIM2 antibody I3MB36 100.0%
ARP50506 Thirteen-lined ground squirrel AIM2 antibody; Spermophilus tridecemlineatus AIM2 antibody I3MB36 86.0%
ARP50506 White-tufted-ear marmoset AIM2 antibody; Callithrix jacchus AIM2 antibody F7HIE2 100.0%
ARP50505 White-tufted-ear marmoset AIM2 antibody; Callithrix jacchus AIM2 antibody F7HIE2 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206513_at721_B_lymphoblasts8.9507.860Details
BioGPS Gene Atlas206513_atAdipocyte5.5007.860Details
BioGPS Gene Atlas206513_atAdrenalCortex6.2007.860Details
BioGPS Gene Atlas206513_atAdrenalgland4.8507.860Details
BioGPS Gene Atlas206513_atAmygdala5.9007.860Details
BioGPS Gene Atlas206513_atAppendix10.9007.860Details
BioGPS Gene Atlas206513_atAtrioventricularNode4.5507.860Details
BioGPS Gene Atlas206513_atBDCA4+_DentriticCells6.2007.860Details
BioGPS Gene Atlas206513_atBonemarrow5.7507.860Details
BioGPS Gene Atlas206513_atBronchialEpithelialCells5.4007.860Details
BioGPS Gene Atlas206513_atCD105+_Endothelial5.4007.860Details
BioGPS Gene Atlas206513_atCD14+_Monocytes6.9507.860Details
BioGPS Gene Atlas206513_atCD19+_BCells(neg._sel.)75.9507.860Details
BioGPS Gene Atlas206513_atCD33+_Myeloid7.8007.860Details
BioGPS Gene Atlas206513_atCD34+6.6507.860Details
BioGPS Gene Atlas206513_atCD4+_Tcells5.7507.860Details
BioGPS Gene Atlas206513_atCD56+_NKCells6.2507.860Details
BioGPS Gene Atlas206513_atCD71+_EarlyErythroid5.2507.860Details
BioGPS Gene Atlas206513_atCD8+_Tcells5.0507.860Details
BioGPS Gene Atlas206513_atCardiacMyocytes7.2507.860Details
BioGPS Gene Atlas206513_atCaudatenucleus5.1007.860Details
BioGPS Gene Atlas206513_atCerebellum4.6007.860Details
BioGPS Gene Atlas206513_atCerebellumPeduncles6.5507.860Details
BioGPS Gene Atlas206513_atCiliaryGanglion4.3007.860Details
BioGPS Gene Atlas206513_atCingulateCortex5.8507.860Details
BioGPS Gene Atlas206513_atColorectaladenocarcinoma5.6007.860Details
BioGPS Gene Atlas206513_atDorsalRootGanglion4.5507.860Details
BioGPS Gene Atlas206513_atFetalThyroid5.4507.860Details
BioGPS Gene Atlas206513_atFetalbrain6.0507.860Details
BioGPS Gene Atlas206513_atFetalliver5.0007.860Details
BioGPS Gene Atlas206513_atFetallung4.8007.860Details
BioGPS Gene Atlas206513_atGlobusPallidus4.2007.860Details
BioGPS Gene Atlas206513_atHeart7.9007.860Details
BioGPS Gene Atlas206513_atHypothalamus5.9007.860Details
BioGPS Gene Atlas206513_atKidney4.7507.860Details
BioGPS Gene Atlas206513_atLeukemia_chronicMyelogenousK-5625.1007.860Details
BioGPS Gene Atlas206513_atLeukemia_promyelocytic-HL-6022.1507.860Details
BioGPS Gene Atlas206513_atLeukemialymphoblastic(MOLT-4)4.5007.860Details
BioGPS Gene Atlas206513_atLiver7.7507.860Details
BioGPS Gene Atlas206513_atLung6.2007.860Details
BioGPS Gene Atlas206513_atLymphnode17.4507.860Details
BioGPS Gene Atlas206513_atLymphoma_burkitts(Daudi)35.1007.860Details
BioGPS Gene Atlas206513_atLymphoma_burkitts(Raji)10.3507.860Details
BioGPS Gene Atlas206513_atMedullaOblongata5.3007.860Details
BioGPS Gene Atlas206513_atOccipitalLobe5.0007.860Details
BioGPS Gene Atlas206513_atOlfactoryBulb4.6007.860Details
BioGPS Gene Atlas206513_atOvary3.8507.860Details
BioGPS Gene Atlas206513_atPancreas5.8507.860Details
BioGPS Gene Atlas206513_atPancreaticIslet6.0507.860Details
BioGPS Gene Atlas206513_atParietalLobe6.1007.860Details
BioGPS Gene Atlas206513_atPituitary10.4007.860Details
BioGPS Gene Atlas206513_atPlacenta5.7007.860Details
BioGPS Gene Atlas206513_atPons7.1507.860Details
BioGPS Gene Atlas206513_atPrefrontalCortex6.9007.860Details
BioGPS Gene Atlas206513_atProstate6.6007.860Details
BioGPS Gene Atlas206513_atSalivarygland4.6507.860Details
BioGPS Gene Atlas206513_atSkeletalMuscle7.2007.860Details
BioGPS Gene Atlas206513_atSkin4.5507.860Details
BioGPS Gene Atlas206513_atSmoothMuscle6.2007.860Details
BioGPS Gene Atlas206513_atSpinalcord6.0507.860Details
BioGPS Gene Atlas206513_atSubthalamicNucleus5.2507.860Details
BioGPS Gene Atlas206513_atSuperiorCervicalGanglion7.1507.860Details
BioGPS Gene Atlas206513_atTemporalLobe5.2007.860Details
BioGPS Gene Atlas206513_atTestis4.8007.860Details
BioGPS Gene Atlas206513_atTestisGermCell4.7507.860Details
BioGPS Gene Atlas206513_atTestisIntersitial4.7507.860Details
BioGPS Gene Atlas206513_atTestisLeydigCell5.6007.860Details
BioGPS Gene Atlas206513_atTestisSeminiferousTubule4.7507.860Details
BioGPS Gene Atlas206513_atThalamus5.7507.860Details
BioGPS Gene Atlas206513_atThymus4.4007.860Details
BioGPS Gene Atlas206513_atThyroid6.8507.860Details
BioGPS Gene Atlas206513_atTongue7.2507.860Details
BioGPS Gene Atlas206513_atTonsil29.9507.860Details
BioGPS Gene Atlas206513_atTrachea4.7007.860Details
BioGPS Gene Atlas206513_atTrigeminalGanglion7.3507.860Details
BioGPS Gene Atlas206513_atUterus5.2507.860Details
BioGPS Gene Atlas206513_atUterusCorpus8.3507.860Details
BioGPS Gene Atlas206513_atWholeBlood18.2507.860Details
BioGPS Gene Atlas206513_atWholebrain5.0007.860Details
BioGPS Gene Atlas206513_atcolon5.6507.860Details
BioGPS Gene Atlas206513_atpineal_day6.7607.860Details
BioGPS Gene Atlas206513_atpineal_night6.7407.860Details
BioGPS Gene Atlas206513_atretina6.7007.860Details
BioGPS Gene Atlas206513_atsmall_intestine5.3507.860Details
BioGPS NCI60206513_at7865.69335.600Details
BioGPS NCI60206513_atA1725.16235.600Details
BioGPS NCI60206513_atA2045.57835.600Details
BioGPS NCI60206513_atA3615.68935.600Details
BioGPS NCI60206513_atA4985.57235.600Details
BioGPS NCI60206513_atA5495.75035.600Details
BioGPS NCI60206513_atACC36.10835.600Details
BioGPS NCI60206513_atACHN4.97935.600Details
BioGPS NCI60206513_atALVA316.10535.600Details
BioGPS NCI60206513_atCAKI15.98135.600Details
BioGPS NCI60206513_atCCRT CEM6.94035.600Details
BioGPS NCI60206513_atCOLO2055.64535.600Details
BioGPS NCI60206513_atDLD15.52335.600Details
BioGPS NCI60206513_atDU1455.22635.600Details
BioGPS NCI60206513_atEKVX5.20635.600Details
BioGPS NCI60206513_atGM133216.75435.600Details
BioGPS NCI60206513_atGM16005.94235.600Details
BioGPS NCI60206513_atGM23135.72335.600Details
BioGPS NCI60206513_atGM23455.64035.600Details
BioGPS NCI60206513_atGM24936.04035.600Details
BioGPS NCI60206513_atGM976.47035.600Details
BioGPS NCI60206513_atHCC29984.98435.600Details
BioGPS NCI60206513_atHCT1165.60535.600Details
BioGPS NCI60206513_atHCT155.10135.600Details
BioGPS NCI60206513_atHEK 293 T-rex5.89335.600Details
BioGPS NCI60206513_atHEK 293T5.66035.600Details
BioGPS NCI60206513_atHEK2935.68135.600Details
BioGPS NCI60206513_atHELA5.09835.600Details
BioGPS NCI60206513_atHEPG25.60035.600Details
BioGPS NCI60206513_atHL60152.08735.600Details
BioGPS NCI60206513_atHOP62176.24335.600Details
BioGPS NCI60206513_atHOP92328.89735.600Details
BioGPS NCI60206513_atHS578T5.43435.600Details
BioGPS NCI60206513_atHSG5.45735.600Details
BioGPS NCI60206513_atHT10806.03335.600Details
BioGPS NCI60206513_atHT296.18435.600Details
BioGPS NCI60206513_atIGROV15.55235.600Details
BioGPS NCI60206513_atIOSE805.50135.600Details
BioGPS NCI60206513_atJURKAT5.58035.600Details
BioGPS NCI60206513_atK5626.29035.600Details
BioGPS NCI60206513_atKM125.94735.600Details
BioGPS NCI60206513_atLN185.39735.600Details
BioGPS NCI60206513_atLNCAP5.65235.600Details
BioGPS NCI60206513_atLOX IMVI635.71035.600Details
BioGPS NCI60206513_atM145.53235.600Details
BioGPS NCI60206513_atMALME 3M6.10935.600Details
BioGPS NCI60206513_atMCF75.32535.600Details
BioGPS NCI60206513_atMD MB2316.18835.600Details
BioGPS NCI60206513_atMDA MB4356.18435.600Details
BioGPS NCI60206513_atMOLT45.98635.600Details
BioGPS NCI60206513_atNCI 4605.80735.600Details
BioGPS NCI60206513_atNCI H2265.80135.600Details
BioGPS NCI60206513_atNCI H235.60435.600Details
BioGPS NCI60206513_atNCI H322M5.61035.600Details
BioGPS NCI60206513_atNCVADR RES5.07835.600Details
BioGPS NCI60206513_atOVCAR35.98435.600Details
BioGPS NCI60206513_atOVCAR45.57435.600Details
BioGPS NCI60206513_atOVCAR55.51535.600Details
BioGPS NCI60206513_atOVCAR85.18335.600Details
BioGPS NCI60206513_atPANC15.66035.600Details
BioGPS NCI60206513_atRL714.53635.600Details
BioGPS NCI60206513_atRPMI 82265.82435.600Details
BioGPS NCI60206513_atRS1184631.04135.600Details
BioGPS NCI60206513_atRXF39314.48135.600Details
BioGPS NCI60206513_atSAOS25.67335.600Details
BioGPS NCI60206513_atSF2685.54635.600Details
BioGPS NCI60206513_atSF2955.53535.600Details
BioGPS NCI60206513_atSF5395.25735.600Details
BioGPS NCI60206513_atSHSYSY+RA5.40035.600Details
BioGPS NCI60206513_atSHSYSY-RA5.52635.600Details
BioGPS NCI60206513_atSKMEL25.87835.600Details
BioGPS NCI60206513_atSKMEL285.93035.600Details
BioGPS NCI60206513_atSKMEL55.33835.600Details
BioGPS NCI60206513_atSKOV35.75435.600Details
BioGPS NCI60206513_atSN12C5.54335.600Details
BioGPS NCI60206513_atSNB195.09335.600Details
BioGPS NCI60206513_atSNB755.49235.600Details
BioGPS NCI60206513_atSR1551.24135.600Details
BioGPS NCI60206513_atSW6205.72035.600Details
BioGPS NCI60206513_atT245.77235.600Details
BioGPS NCI60206513_atT3M45.90735.600Details
BioGPS NCI60206513_atTK105.58735.600Details
BioGPS NCI60206513_atU1186.59835.600Details
BioGPS NCI60206513_atU1385.09835.600Details
BioGPS NCI60206513_atU20S5.56435.600Details
BioGPS NCI60206513_atU2515.47035.600Details
BioGPS NCI60206513_atU8713.81635.600Details
BioGPS NCI60206513_atUACC2575.35735.600Details
BioGPS NCI60206513_atUACC625.73535.600Details
BioGPS NCI60206513_atUO315.30635.600Details
BioGPS NCI60206513_atZR75_15.88935.600Details
BioGPS NCI60206513_atastrocytes5.64335.600Details
BioGPS NCI60206513_athuh-75.85435.600Details