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Gene ID: 9507 | Adamts4 Antibody Resource


Adamts4 Antibody Resource
Gene Full Name: 
ADAM metallopeptidase with thrombospondin type 1 motif, 4
Uniprot: 
O75173
Protein Name: 
A disintegrin and metalloproteinase with thrombospondin motifs 4
Nucleotide: 
NM_005099
Alias: 
ADMP-1;ADAMTS-2;ADAMTS-4;
Ensembl: 
Location: 
1q21-q23
HPRD: 
04853
NCBI Gene: 
9507
MIM: 
603876

Summary: 
This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene lacks a C-terminal TS motif. It is responsible for the degradation of aggrecan, a major proteoglycan of cartilage, and brevican, a brain-specific extracellular matrix protein. The cleavage of aggrecan and brevican suggests key roles of this enzyme in arthritic disease and in the central nervous system, potentially, in the progression of glioma. [provided by RefSeq, Jul 2008]
Function: 
Cleaves aggrecan, a cartilage proteoglycan, and may be involved in its turnover. May play an important role in the destruction of aggrecan in arthritic diseases. Could also be a critical factor in the exacerbation of neurodegeneration in Alzheimer disease. Cleaves aggrecan at the '392-Glu-|-Ala-393' site.
Subcellular location: 
Secreted › extracellular space › extracellular matrix.
PTM: 
Cleavage on pair of basic residues;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP41556_P050 ADAMTS4 antibody - N-terminal region (ARP41556_P050) Polyclonal Bovine, Dog, Horse, Human, Mouse, Pig IHC, WB 50ug $289 Details
Polyclonal Antibody OASA07380 ADAMTS4 antibody - C-terminal region (OASA07380) Human IHC-AFF, WB 0.15mg $725 Details
Polyclonal Antibody OASA07381 ADAMTS4 antibody - C-terminal region (OASA07381) Human WB 0.1mg $645 Details
Polyclonal Antibody OAAB04466 ADAMTS4 antibody - C-terminal region (OAAB04466) Human; Mouse WB, ELISA 400ul $289 Details
Polyclonal Antibody ARP41555_P050 Adamts4 antibody - N-terminal region (ARP41555_P050) Rat; Human WB 50ug $289 Details

Show all Adamts4 antibodies


Product Images
Adamts4 antibody - N-terminal region (ARP41555_P050) in Rat Kidney cells using Western Blot

Sample Type: Rat Kidney

ADAMTS4 antibody - N-terminal region (ARP41556_P050) in Human HepG2 cells using Western Blot

Sample Type: Human HepG2

ADAMTS4 antibody - N-terminal region (ARP41556_P050) in Human Kidney cells using Immunohistochemistry

Sample Type: Human Kidney

ADAMTS4 antibody - C-terminal region (OAAB04466) in mouse cerebellum cells using Western Blot

Sample Type: mouse cerebellum


Adamts4 Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP41555 Bovine Adamts4 antibody; Bos taurus Adamts4 antibody Q9TT93 100.0%
ARP41556 Bovine Adamts4 antibody; Bos taurus Adamts4 antibody Q9TT93 100.0%
ARP41555 Bovine Adamts4 antibody; Bos taurus Adamts4 antibody G8JKX1 100.0%
ARP41556 Bovine Adamts4 antibody; Bos taurus Adamts4 antibody G8JKX1 100.0%
ARP41555 Cat Adamts4 antibody; Felis catus Adamts4 antibody M3VUV7 100.0%
ARP41556 Cat Adamts4 antibody; Felis catus Adamts4 antibody M3VUV7 93.0%
ARP41555 Chimpanzee Adamts4 antibody; Pan troglodytes Adamts4 antibody H2R0A6 100.0%
ARP41556 Chimpanzee Adamts4 antibody; Pan troglodytes Adamts4 antibody H2R0A6 100.0%
ARP41555 Dog Adamts4 antibody; Canis familiaris Adamts4 antibody E2RFF5 100.0%
ARP41556 Dog Adamts4 antibody; Canis familiaris Adamts4 antibody E2RFF5 93.0%
ARP41555 European domestic ferret Adamts4 antibody; Mustela putorius furo Adamts4 antibody M3YS56 100.0%
ARP41556 European domestic ferret Adamts4 antibody; Mustela putorius furo Adamts4 antibody M3YS56 93.0%
ARP41555 Giant panda Adamts4 antibody; Ailuropoda melanoleuca Adamts4 antibody D2I0T1 100.0%
ARP41556 Giant panda Adamts4 antibody; Ailuropoda melanoleuca Adamts4 antibody D2I0T1 100.0%
ARP41556 Gray short-tailed opossum Adamts4 antibody; Monodelphis domestica Adamts4 antibody F7DMX5 100.0%
ARP41555 Gray short-tailed opossum Adamts4 antibody; Monodelphis domestica Adamts4 antibody F7DMX5 83.0%
ARP41555 Horse Adamts4 antibody; Equus caballus Adamts4 antibody F6YRD3 100.0%
ARP41556 Horse Adamts4 antibody; Equus caballus Adamts4 antibody F6YRD3 100.0%
ARP41555 Human Adamts4 antibody; Homo sapiens Adamts4 antibody Q5VTW1 100.0%
ARP41556 Human Adamts4 antibody; Homo sapiens Adamts4 antibody Q5VTW1 100.0%
ARP41555 Human Adamts4 antibody; Homo sapiens Adamts4 antibody O75173 100.0%
ARP41556 Human Adamts4 antibody; Homo sapiens Adamts4 antibody O75173 100.0%
ARP41556 Mouse Adamts4 antibody; Mus musculus Adamts4 antibody Q3TNX8 100.0%
ARP41555 Mouse Adamts4 antibody; Mus musculus Adamts4 antibody Q3U025 100.0%
ARP41556 Mouse Adamts4 antibody; Mus musculus Adamts4 antibody Q3U025 100.0%
ARP41555 Mouse Adamts4 antibody; Mus musculus Adamts4 antibody Q8BNJ2 100.0%
ARP41556 Mouse Adamts4 antibody; Mus musculus Adamts4 antibody Q8BNJ2 100.0%
ARP41555 Mouse Adamts4 antibody; Mus musculus Adamts4 antibody Q3TNX8 100.0%
ARP41555 Northern white-cheeked gibbon Adamts4 antibody; Nomascus leucogenys Adamts4 antibody G1RV89 100.0%
ARP41556 Northern white-cheeked gibbon Adamts4 antibody; Nomascus leucogenys Adamts4 antibody G1RV89 100.0%
ARP41555 Pig Adamts4 antibody; Sus scrofa Adamts4 antibody F1S1A7 100.0%
ARP41556 Pig Adamts4 antibody; Sus scrofa Adamts4 antibody F1S1A7 100.0%
ARP41555 Rhesus macaque Adamts4 antibody; Macaca mulatta Adamts4 antibody G7ME94 100.0%
ARP41556 Rhesus macaque Adamts4 antibody; Macaca mulatta Adamts4 antibody G7ME94 100.0%
ARP41556 Small-eared galago Adamts4 antibody; Otolemur garnettii Adamts4 antibody H0X9N5 100.0%
ARP41555 Small-eared galago Adamts4 antibody; Otolemur garnettii Adamts4 antibody H0X9N5 93.0%
ARP41555 Sumatran orangutan Adamts4 antibody; Pongo abelii Adamts4 antibody Q5RFQ8 100.0%
ARP41555 Sumatran orangutan Adamts4 antibody; Pongo abelii Adamts4 antibody H2N516 100.0%
ARP41556 Sumatran orangutan Adamts4 antibody; Pongo abelii Adamts4 antibody H2N516 100.0%
ARP41556 Sumatran orangutan Adamts4 antibody; Pongo abelii Adamts4 antibody Q5RFQ8 93.0%
ARP41556 Tasmanian devil Adamts4 antibody; Sarcophilus harrisii Adamts4 antibody G3WVQ6 100.0%
ARP41555 Thirteen-lined ground squirrel Adamts4 antibody; Spermophilus tridecemlineatus Adamts4 antibody I3M807 100.0%
ARP41556 Thirteen-lined ground squirrel Adamts4 antibody; Spermophilus tridecemlineatus Adamts4 antibody I3M807 100.0%
ARP41555 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody F7H2R3 100.0%
ARP41555 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody U3C182 100.0%
ARP41556 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody F7H2R3 100.0%
ARP41556 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody U3C182 100.0%
ARP41555 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody U3CN59 100.0%
ARP41556 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody U3CN59 100.0%
ARP41555 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody U3ETP4 100.0%
ARP41556 White-tufted-ear marmoset Adamts4 antibody; Callithrix jacchus Adamts4 antibody U3ETP4 100.0%

Tissue & Cell Line Gene Expression Data