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Gene ID: 95 | ACY1 Antibody Resource


ACY1 Antibody Resource
Gene Full Name: 
aminoacylase 1
Uniprot: 
Q03154
Protein Name: 
aminoacylase-1
Nucleotide: 
NM_000666
Alias: 
ACY-1;ACY1D;
Ensembl: 
ENSG00000114786
Location: 
3p21.1
HPRD: 
00092
NCBI Gene: 
95
MIM: 
104620

Summary: 
This gene encodes a cytosolic, homodimeric, zinc-binding enzyme that catalyzes the hydrolysis of acylated L-amino acids to L-amino acids and an acyl group, and has been postulated to function in the catabolism and salvage of acylated amino acids. This gene is located on chromosome 3p21.1, a region reduced to homozygosity in small-cell lung cancer (SCLC), and its expression has been reported to be reduced or undetectable in SCLC cell lines and tumors. The amino acid sequence of human aminoacylase-1 is highly homologous to the porcine counterpart, and this enzyme is the first member of a new family of zinc-binding enzymes. Mutations in this gene cause aminoacylase-1 deficiency, a metabolic disorder characterized by central nervous system defects and increased urinary excretion of N-acetylated amino acids. Alternative splicing of this gene results in multiple transcript variants. Read-through transcription also exists between this gene and the upstream ABHD14A (abhydrolase domain containing 14A) gene, as represented in GeneID:100526760. A related pseudogene has been identified on chromosome 18. [provided by RefSeq, Nov 2010]
Function: 
Involved in the hydrolysis of N-acylated or N-acetylated amino acids (except L-aspartate).
Subcellular location: 
Cytoplasm.
PTM: 
Disease: 
Aminoacylase-1 deficiency (ACY1D) [MIM:609924]: An enzymatic deficiency resulting in encephalopathy, unspecific psychomotor delay, psychomotor delay with atrophy of the vermis and syringomyelia, marked muscular hypotonia or normal clinical features. Epileptic seizures are a frequent feature. All affected individuals exhibit markedly increased urinary excretion of several N-acetylated amino acids. Note: The disease is caused by mutations affecting the gene represented in this entry.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Protein OPPA00817 ACY1 Human - Recombinant Human AminoAcylase-1 (2ug) 2ug $100 Details
Polyclonal Antibody ARP61383_P050 ACY1 Antibody (ARP61383_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody ARP61384_P050 ACY1 Antibody (ARP61384_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat Not tested 50 ug $125 Details
Polyclonal Antibody OAAB08295 ACY1 antibody - center region (OAAB08295) Human WB, IHC 400ul $289 Details
Polyclonal Antibody OAGA00844 ACY1 antibody (OAGA00844) Polyclonal Human ICC/IF, WB 100 ul $340 Details

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Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP61383 African elephant ACY1 antibody; Loxodonta africana ACY1 antibody G3SWU1 86.0%
ARP61383 Bovine ACY1 antibody; Bos taurus ACY1 antibody Q3T0V2 79.0%
ARP61384 Bovine ACY1 antibody; Bos taurus ACY1 antibody Q3T0V2 79.0%
ARP61384 Chimpanzee ACY1 antibody; Pan troglodytes ACY1 antibody K7BXN5 100.0%
ARP61383 Chimpanzee ACY1 antibody; Pan troglodytes ACY1 antibody K7CQ78 100.0%
ARP61384 Chimpanzee ACY1 antibody; Pan troglodytes ACY1 antibody K7CQ78 100.0%
ARP61383 Dog ACY1 antibody; Canis familiaris ACY1 antibody F1PHI4 86.0%
ARP61384 Dog ACY1 antibody; Canis familiaris ACY1 antibody F1PHI4 79.0%
ARP61383 European domestic ferret ACY1 antibody; Mustela putorius furo ACY1 antibody M3YJZ7 79.0%
ARP61384 Horse ACY1 antibody; Equus caballus ACY1 antibody F6R8T8 79.0%
ARP61383 Human ACY1 antibody; Homo sapiens ACY1 antibody B4DNW0 100.0%
ARP61384 Human ACY1 antibody; Homo sapiens ACY1 antibody B4DNW0 100.0%
ARP61384 Human ACY1 antibody; Homo sapiens ACY1 antibody C9JYZ0 100.0%
ARP61383 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154-2 100.0%
ARP61384 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154-2 100.0%
ARP61384 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154-3 100.0%
ARP61383 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154-4 100.0%
ARP61384 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154-4 100.0%
ARP61383 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154 100.0%
ARP61384 Human ACY1 antibody; Homo sapiens ACY1 antibody Q03154 100.0%
ARP61383 Mouse ACY1 antibody; Mus musculus ACY1 antibody Q99JW2 86.0%
ARP61384 Mouse ACY1 antibody; Mus musculus ACY1 antibody Q99JW2 86.0%
ARP61384 Northern white-cheeked gibbon ACY1 antibody; Nomascus leucogenys ACY1 antibody G1R600 100.0%
ARP61383 Northern white-cheeked gibbon ACY1 antibody; Nomascus leucogenys ACY1 antibody G1R600 93.0%
ARP61384 Pig ACY1 antibody; Sus scrofa ACY1 antibody P37111 79.0%
ARP61383 Rhesus macaque ACY1 antibody; Macaca mulatta ACY1 antibody H9EWL7 93.0%
ARP61383 Rhesus macaque ACY1 antibody; Macaca mulatta ACY1 antibody H9Z113 93.0%
ARP61384 Rhesus macaque ACY1 antibody; Macaca mulatta ACY1 antibody H9EWL7 79.0%
ARP61384 Rhesus macaque ACY1 antibody; Macaca mulatta ACY1 antibody H9Z113 79.0%
ARP61383 Sumatran orangutan ACY1 antibody; Pongo abelii ACY1 antibody H2PAL1 100.0%
ARP61384 Sumatran orangutan ACY1 antibody; Pongo abelii ACY1 antibody H2PAL1 100.0%
ARP61383 Sumatran orangutan ACY1 antibody; Pongo abelii ACY1 antibody Q5RFB0 100.0%
ARP61384 Sumatran orangutan ACY1 antibody; Pongo abelii ACY1 antibody Q5RFB0 100.0%
ARP61383 White-tufted-ear marmoset ACY1 antibody; Callithrix jacchus ACY1 antibody U3FP55 93.0%
ARP61383 White-tufted-ear marmoset ACY1 antibody; Callithrix jacchus ACY1 antibody U3DX56 93.0%
ARP61384 White-tufted-ear marmoset ACY1 antibody; Callithrix jacchus ACY1 antibody U3DX56 86.0%
ARP61384 White-tufted-ear marmoset ACY1 antibody; Callithrix jacchus ACY1 antibody U3FP55 86.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas202740_at721_B_lymphoblasts81.90068.620Details
BioGPS Gene Atlas202740_atAdipocyte90.90068.620Details
BioGPS Gene Atlas202740_atAdrenalCortex23.85068.620Details
BioGPS Gene Atlas202740_atAdrenalgland37.10068.620Details
BioGPS Gene Atlas202740_atAmygdala18.05068.620Details
BioGPS Gene Atlas202740_atAppendix16.05068.620Details
BioGPS Gene Atlas202740_atAtrioventricularNode14.80068.620Details
BioGPS Gene Atlas202740_atBDCA4+_DentriticCells17.90068.620Details
BioGPS Gene Atlas202740_atBonemarrow11.85068.620Details
BioGPS Gene Atlas202740_atBronchialEpithelialCells81.45068.620Details
BioGPS Gene Atlas202740_atCD105+_Endothelial63.10068.620Details
BioGPS Gene Atlas202740_atCD14+_Monocytes19.55068.620Details
BioGPS Gene Atlas202740_atCD19+_BCells(neg._sel.)22.15068.620Details
BioGPS Gene Atlas202740_atCD33+_Myeloid26.60068.620Details
BioGPS Gene Atlas202740_atCD34+80.75068.620Details
BioGPS Gene Atlas202740_atCD4+_Tcells18.85068.620Details
BioGPS Gene Atlas202740_atCD56+_NKCells22.70068.620Details
BioGPS Gene Atlas202740_atCD71+_EarlyErythroid12.45068.620Details
BioGPS Gene Atlas202740_atCD8+_Tcells19.80068.620Details
BioGPS Gene Atlas202740_atCardiacMyocytes20.60068.620Details
BioGPS Gene Atlas202740_atCaudatenucleus17.15068.620Details
BioGPS Gene Atlas202740_atCerebellum16.50068.620Details
BioGPS Gene Atlas202740_atCerebellumPeduncles16.40068.620Details
BioGPS Gene Atlas202740_atCiliaryGanglion10.55068.620Details
BioGPS Gene Atlas202740_atCingulateCortex20.00068.620Details
BioGPS Gene Atlas202740_atColorectaladenocarcinoma122.00068.620Details
BioGPS Gene Atlas202740_atDorsalRootGanglion12.95068.620Details
BioGPS Gene Atlas202740_atFetalThyroid16.60068.620Details
BioGPS Gene Atlas202740_atFetalbrain17.25068.620Details
BioGPS Gene Atlas202740_atFetalliver53.90068.620Details
BioGPS Gene Atlas202740_atFetallung20.95068.620Details
BioGPS Gene Atlas202740_atGlobusPallidus14.65068.620Details
BioGPS Gene Atlas202740_atHeart58.00068.620Details
BioGPS Gene Atlas202740_atHypothalamus24.80068.620Details
BioGPS Gene Atlas202740_atKidney1816.00068.620Details
BioGPS Gene Atlas202740_atLeukemia_chronicMyelogenousK-56286.95068.620Details
BioGPS Gene Atlas202740_atLeukemia_promyelocytic-HL-6021.95068.620Details
BioGPS Gene Atlas202740_atLeukemialymphoblastic(MOLT-4)17.05068.620Details
BioGPS Gene Atlas202740_atLiver1710.40068.620Details
BioGPS Gene Atlas202740_atLung29.40068.620Details
BioGPS Gene Atlas202740_atLymphnode16.05068.620Details
BioGPS Gene Atlas202740_atLymphoma_burkitts(Daudi)25.85068.620Details
BioGPS Gene Atlas202740_atLymphoma_burkitts(Raji)72.45068.620Details
BioGPS Gene Atlas202740_atMedullaOblongata16.95068.620Details
BioGPS Gene Atlas202740_atOccipitalLobe16.85068.620Details
BioGPS Gene Atlas202740_atOlfactoryBulb17.20068.620Details
BioGPS Gene Atlas202740_atOvary6.00068.620Details
BioGPS Gene Atlas202740_atPancreas19.50068.620Details
BioGPS Gene Atlas202740_atPancreaticIslet21.75068.620Details
BioGPS Gene Atlas202740_atParietalLobe21.20068.620Details
BioGPS Gene Atlas202740_atPituitary24.00068.620Details
BioGPS Gene Atlas202740_atPlacenta19.65068.620Details
BioGPS Gene Atlas202740_atPons19.85068.620Details
BioGPS Gene Atlas202740_atPrefrontalCortex21.65068.620Details
BioGPS Gene Atlas202740_atProstate37.25068.620Details
BioGPS Gene Atlas202740_atSalivarygland16.10068.620Details
BioGPS Gene Atlas202740_atSkeletalMuscle63.80068.620Details
BioGPS Gene Atlas202740_atSkin15.10068.620Details
BioGPS Gene Atlas202740_atSmoothMuscle20.35068.620Details
BioGPS Gene Atlas202740_atSpinalcord21.90068.620Details
BioGPS Gene Atlas202740_atSubthalamicNucleus15.70068.620Details
BioGPS Gene Atlas202740_atSuperiorCervicalGanglion20.40068.620Details
BioGPS Gene Atlas202740_atTemporalLobe18.50068.620Details
BioGPS Gene Atlas202740_atTestis15.55068.620Details
BioGPS Gene Atlas202740_atTestisGermCell13.65068.620Details
BioGPS Gene Atlas202740_atTestisIntersitial6.95068.620Details
BioGPS Gene Atlas202740_atTestisLeydigCell20.05068.620Details
BioGPS Gene Atlas202740_atTestisSeminiferousTubule16.20068.620Details
BioGPS Gene Atlas202740_atThalamus20.60068.620Details
BioGPS Gene Atlas202740_atThymus14.45068.620Details
BioGPS Gene Atlas202740_atThyroid62.05068.620Details
BioGPS Gene Atlas202740_atTongue19.95068.620Details
BioGPS Gene Atlas202740_atTonsil18.50068.620Details
BioGPS Gene Atlas202740_atTrachea20.75068.620Details
BioGPS Gene Atlas202740_atTrigeminalGanglion19.60068.620Details
BioGPS Gene Atlas202740_atUterus16.40068.620Details
BioGPS Gene Atlas202740_atUterusCorpus19.05068.620Details
BioGPS Gene Atlas202740_atWholeBlood12.05068.620Details
BioGPS Gene Atlas202740_atWholebrain16.05068.620Details
BioGPS Gene Atlas202740_atcolon31.30068.620Details
BioGPS Gene Atlas202740_atpineal_day24.20068.620Details
BioGPS Gene Atlas202740_atpineal_night21.24068.620Details
BioGPS Gene Atlas202740_atretina24.50068.620Details
BioGPS Gene Atlas202740_atsmall_intestine181.20068.620Details
BioGPS NCI60202740_at786298.242462.940Details
BioGPS NCI60202740_atA172443.781462.940Details
BioGPS NCI60202740_atA204228.854462.940Details
BioGPS NCI60202740_atA3611335.965462.940Details
BioGPS NCI60202740_atA498223.024462.940Details
BioGPS NCI60202740_atA549225.300462.940Details
BioGPS NCI60202740_atACC3569.870462.940Details
BioGPS NCI60202740_atACHN464.646462.940Details
BioGPS NCI60202740_atALVA31243.057462.940Details
BioGPS NCI60202740_atCAKI1229.158462.940Details
BioGPS NCI60202740_atCCRT CEM229.131462.940Details
BioGPS NCI60202740_atCOLO205390.991462.940Details
BioGPS NCI60202740_atDLD1521.531462.940Details
BioGPS NCI60202740_atDU145238.039462.940Details
BioGPS NCI60202740_atEKVX181.083462.940Details
BioGPS NCI60202740_atGM133213.711462.940Details
BioGPS NCI60202740_atGM1600126.938462.940Details
BioGPS NCI60202740_atGM2313117.576462.940Details
BioGPS NCI60202740_atGM2345167.797462.940Details
BioGPS NCI60202740_atGM249380.867462.940Details
BioGPS NCI60202740_atGM97229.621462.940Details
BioGPS NCI60202740_atHCC29983339.396462.940Details
BioGPS NCI60202740_atHCT116409.459462.940Details
BioGPS NCI60202740_atHCT15701.682462.940Details
BioGPS NCI60202740_atHEK 293 T-rex211.178462.940Details
BioGPS NCI60202740_atHEK 293T293.695462.940Details
BioGPS NCI60202740_atHEK293149.248462.940Details
BioGPS NCI60202740_atHELA270.870462.940Details
BioGPS NCI60202740_atHEPG21646.234462.940Details
BioGPS NCI60202740_atHL60270.332462.940Details
BioGPS NCI60202740_atHOP62239.174462.940Details
BioGPS NCI60202740_atHOP92186.727462.940Details
BioGPS NCI60202740_atHS578T198.481462.940Details
BioGPS NCI60202740_atHSG633.567462.940Details
BioGPS NCI60202740_atHT1080248.577462.940Details
BioGPS NCI60202740_atHT29429.641462.940Details
BioGPS NCI60202740_atIGROV1624.541462.940Details
BioGPS NCI60202740_atIOSE80239.109462.940Details
BioGPS NCI60202740_atJURKAT237.791462.940Details
BioGPS NCI60202740_atK562541.479462.940Details
BioGPS NCI60202740_atKM12692.244462.940Details
BioGPS NCI60202740_atLN18870.275462.940Details
BioGPS NCI60202740_atLNCAP1649.716462.940Details
BioGPS NCI60202740_atLOX IMVI704.745462.940Details
BioGPS NCI60202740_atM14348.615462.940Details
BioGPS NCI60202740_atMALME 3M244.649462.940Details
BioGPS NCI60202740_atMCF7176.179462.940Details
BioGPS NCI60202740_atMD MB231322.285462.940Details
BioGPS NCI60202740_atMDA MB4352879.446462.940Details
BioGPS NCI60202740_atMOLT499.210462.940Details
BioGPS NCI60202740_atNCI 460440.081462.940Details
BioGPS NCI60202740_atNCI H226311.755462.940Details
BioGPS NCI60202740_atNCI H23197.225462.940Details
BioGPS NCI60202740_atNCI H322M541.045462.940Details
BioGPS NCI60202740_atNCVADR RES260.787462.940Details
BioGPS NCI60202740_atOVCAR3242.257462.940Details
BioGPS NCI60202740_atOVCAR4418.045462.940Details
BioGPS NCI60202740_atOVCAR51246.246462.940Details
BioGPS NCI60202740_atOVCAR8208.336462.940Details
BioGPS NCI60202740_atPANC1547.278462.940Details
BioGPS NCI60202740_atRL7433.951462.940Details
BioGPS NCI60202740_atRPMI 8226962.629462.940Details
BioGPS NCI60202740_atRS11846372.769462.940Details
BioGPS NCI60202740_atRXF393216.476462.940Details
BioGPS NCI60202740_atSAOS2153.362462.940Details
BioGPS NCI60202740_atSF268187.349462.940Details
BioGPS NCI60202740_atSF295208.102462.940Details
BioGPS NCI60202740_atSF539130.930462.940Details
BioGPS NCI60202740_atSHSYSY+RA286.823462.940Details
BioGPS NCI60202740_atSHSYSY-RA221.583462.940Details
BioGPS NCI60202740_atSKMEL2736.046462.940Details
BioGPS NCI60202740_atSKMEL28221.871462.940Details
BioGPS NCI60202740_atSKMEL51412.199462.940Details
BioGPS NCI60202740_atSKOV3119.908462.940Details
BioGPS NCI60202740_atSN12C448.286462.940Details
BioGPS NCI60202740_atSNB19183.824462.940Details
BioGPS NCI60202740_atSNB75199.016462.940Details
BioGPS NCI60202740_atSR348.962462.940Details
BioGPS NCI60202740_atSW620478.696462.940Details
BioGPS NCI60202740_atT24223.926462.940Details
BioGPS NCI60202740_atT3M4431.187462.940Details
BioGPS NCI60202740_atTK10359.106462.940Details
BioGPS NCI60202740_atU118472.765462.940Details
BioGPS NCI60202740_atU138657.575462.940Details
BioGPS NCI60202740_atU20S228.334462.940Details
BioGPS NCI60202740_atU251189.225462.940Details
BioGPS NCI60202740_atU87459.464462.940Details
BioGPS NCI60202740_atUACC257561.582462.940Details
BioGPS NCI60202740_atUACC62741.738462.940Details
BioGPS NCI60202740_atUO31444.635462.940Details
BioGPS NCI60202740_atZR75_1988.444462.940Details
BioGPS NCI60202740_atastrocytes225.868462.940Details
BioGPS NCI60202740_athuh-7729.514462.940Details