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Gene ID: 130013 | ACMSD Antibody Resource


ACMSD Antibody Resource
Gene Full Name: 
aminocarboxymuconate semialdehyde decarboxylase
Uniprot: 
Q8TDX5
Protein Name: 
2-amino-3-carboxymuconate-6-semialdehyde decarboxylase
Nucleotide: 
XM_005263586
Alias: 
Ensembl: 
ENSG00000153086
Location: 
2q21.3
HPRD: 
12326
NCBI Gene: 
130013
MIM: 
608889

Summary: 
The neuronal excitotoxin quinolinate is an intermediate in the de novo synthesis pathway of NAD from tryptophan, and has been implicated in the pathogenesis of several neurodegenerative disorders. Quinolinate is derived from alpha-amino-beta-carboxy-muconate-epsilon-semialdehyde (ACMS). ACMSD (ACMS decarboxylase; EC 4.1.1.45) can divert ACMS to a benign catabolite and thus prevent the accumulation of quinolinate from ACMS.[supplied by OMIM, Oct 2004]
Function: 
Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.
Subcellular location: 
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP45728_P050 ACMSD antibody - middle region (ARP45728_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Mouse, Pig, Rabbit, Rat, Zebrafish WB 50ug $289 Details
Polyclonal Antibody OAAB05550 ACMSD antibody - N-terminal region (OAAB05550) Human WB, FC, IHC, ELISA 400ul $289 Details
Polyclonal Antibody OAGA00530 ACMSD antibody (OAGA00530) Polyclonal Human, Mouse IHC (Formalin-fixed paraffin-embedded sections), WB 100 ul $340 Details

Show all ACMSD antibodies


Product Images
ACMSD antibody - middle region (ARP45728_P050) in Human kidney cells using Western Blot

Sample Type: Human kidney


ACMSD Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP45728 blue catfish ACMSD antibody; Ictalurus furcatus ACMSD antibody E3TDC1 86.0%
ARP45728 Bovine ACMSD antibody; Bos taurus ACMSD antibody Q0II68 100.0%
ARP45728 Cat ACMSD antibody; Felis catus ACMSD antibody M3W199 100.0%
ARP45728 Channel catfish ACMSD antibody; Ictalurus punctatus ACMSD antibody E3TEB8 92.0%
ARP45728 Chimpanzee ACMSD antibody; Pan troglodytes ACMSD antibody H2QIR4 100.0%
ARP45728 Chinese softshell turtle ACMSD antibody; Pelodiscus sinensis ACMSD antibody K7FP40 85.0%
ARP45728 Dog ACMSD antibody; Canis familiaris ACMSD antibody E2RPR4 100.0%
ARP45728 Dog ACMSD antibody; Canis familiaris ACMSD antibody J9P2Q1 100.0%
ARP45728 Duckbill platypus ACMSD antibody; Ornithorhynchus anatinus ACMSD antibody F7E307 92.0%
ARP45728 European domestic ferret ACMSD antibody; Mustela putorius furo ACMSD antibody M3XTX3 100.0%
ARP45728 Giant panda ACMSD antibody; Ailuropoda melanoleuca ACMSD antibody G1MD21 100.0%
ARP45728 Gray short-tailed opossum ACMSD antibody; Monodelphis domestica ACMSD antibody F6SFT6 100.0%
ARP45728 Green anole ACMSD antibody; Anolis carolinensis ACMSD antibody R4G9F7 92.0%
ARP45728 Horse ACMSD antibody; Equus caballus ACMSD antibody F6PWP9 100.0%
ARP45728 Human ACMSD antibody; Homo sapiens ACMSD antibody Q8TDX5-2 100.0%
ARP45728 Human ACMSD antibody; Homo sapiens ACMSD antibody Q8TDX5 100.0%
ARP45728 Mouse ACMSD antibody; Mus musculus ACMSD antibody Q3TNK0 100.0%
ARP45728 Mouse ACMSD antibody; Mus musculus ACMSD antibody Q8R519 100.0%
ARP45728 Pig ACMSD antibody; Sus scrofa ACMSD antibody F1S0C2 100.0%
ARP45728 Rabbit ACMSD antibody; Oryctolagus cuniculus ACMSD antibody G1SDS9 100.0%
ARP45728 Rat ACMSD antibody; Rattus norvegicus ACMSD antibody A9CMA9 93.0%
ARP45728 Rat ACMSD antibody; Rattus norvegicus ACMSD antibody F8WFI2 93.0%
ARP45728 Rat ACMSD antibody; Rattus norvegicus ACMSD antibody Q8R5M5 93.0%
ARP45728 Rhesus macaque ACMSD antibody; Macaca mulatta ACMSD antibody F6SQ09 100.0%
ARP45728 Rhesus macaque ACMSD antibody; Macaca mulatta ACMSD antibody F6SQG9 100.0%
ARP45728 Rhesus macaque ACMSD antibody; Macaca mulatta ACMSD antibody F7HFG7 100.0%
ARP45728 Small-eared galago ACMSD antibody; Otolemur garnettii ACMSD antibody H0WJH2 100.0%
ARP45728 Spotted green pufferfish ACMSD antibody; Tetraodon nigroviridis ACMSD antibody Q4SQ80 85.0%
ARP45728 Sumatran orangutan ACMSD antibody; Pongo abelii ACMSD antibody H2P7F0 100.0%
ARP45728 Tasmanian devil ACMSD antibody; Sarcophilus harrisii ACMSD antibody G3WS71 92.0%
ARP45728 Thirteen-lined ground squirrel ACMSD antibody; Spermophilus tridecemlineatus ACMSD antibody I3MFN8 86.0%
ARP45728 Western clawed frog ACMSD antibody; Xenopus tropicalis ACMSD antibody F7EHT0 85.0%
ARP45728 Zebrafish ACMSD antibody; Danio rerio ACMSD antibody A4QP55 93.0%
ARP45728 Zebrafish ACMSD antibody; Danio rerio ACMSD antibody B0S8J5 93.0%

Tissue & Cell Line Gene Expression Data