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Gene ID: 51554 | ACKR4 Antibody Resource


ACKR4 Antibody Resource
Gene Full Name: 
atypical chemokine receptor 4
Uniprot: 
Q9NPB9
Protein Name: 
atypical chemokine receptor 4
Nucleotide: 
NM_016557
Alias: 
PPR1;CCBP2;CCR10;CCR11;CCRL1;VSHK1;CCR-11;CKR-11;CCX CKR;CCX-CKR;CC-CKR-11;
Ensembl: 
ENSG00000129048
Location: 
3q22
HPRD: 
07298
NCBI Gene: 
51554
MIM: 
606065

Summary: 
The protein encoded by this gene is a member of the G protein-coupled receptor family, and is a receptor for C-C type chemokines. This receptor has been shown to bind dendritic cell- and T cell-activated chemokines including CCL19/ELC, CCL21/SLC, and CCL25/TECK. A pseudogene of this gene is found on chromosome 6. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2013]
Function: 
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines CCL2, CCL8, CCL13, CCL19, CCL21 and CCL25. Chemokine-binding does not activate G-protein-mediated signal transduction but instead induces beta-arrestin recruitment, leading to ligand internalization. Plays an important role in controlling the migration of immune and cancer cells that express chemokine receptors CCR7 and CCR9, by reducing the availability of CCL19, CCL21, and CCL25 through internalization. Negatively regulates CXCR3-induced chemotaxis. Regulates T-cell development in the thymus.
Subcellular location: 
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via caveolae. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
PTM: 
Disulfide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP62099_P050 CCRL1 antibody - C-terminal region (ARP62099_P050) Bovine, Human, Mouse, Pig, Rat IHC, WB 50ug $289 Details
Polyclonal Antibody ARP62100_P050 CCRL1 antibody - C-terminal region (ARP62100_P050) Bovine, Human, Mouse, Pig, Rat WB 50ug $289 Details

Show all ACKR4 antibodies


Product Images
CCRL1 antibody - C-terminal region (ARP62099_P050) in Human 293T cells using Western Blot

Sample Type: Human 293T

CCRL1 antibody - C-terminal region (ARP62099_P050) in human gastrointestinal cells using Immunohistochemistry

Sample Type: human gastrointestinal

CCRL1 antibody - C-terminal region (ARP62100_P050) in Human 721_B cells using Western Blot

Sample Type: Human 721_B


ACKR4 Protocols
Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP62099 Bovine ACKR4 antibody; Bos taurus ACKR4 antibody P35350 93.0%
ARP62100 Bovine ACKR4 antibody; Bos taurus ACKR4 antibody P35350 79.0%
ARP62100 Cat ACKR4 antibody; Felis catus ACKR4 antibody M3W144 93.0%
ARP62099 Cat ACKR4 antibody; Felis catus ACKR4 antibody M3W144 86.0%
ARP62100 Dog ACKR4 antibody; Canis familiaris ACKR4 antibody E2QZY3 93.0%
ARP62099 Dog ACKR4 antibody; Canis familiaris ACKR4 antibody E2QZY3 86.0%
ARP62099 European domestic ferret ACKR4 antibody; Mustela putorius furo ACKR4 antibody M3Z4N7 93.0%
ARP62100 European domestic ferret ACKR4 antibody; Mustela putorius furo ACKR4 antibody M3Z4N7 86.0%
ARP62099 Giant panda ACKR4 antibody; Ailuropoda melanoleuca ACKR4 antibody D2HUH5 93.0%
ARP62100 Giant panda ACKR4 antibody; Ailuropoda melanoleuca ACKR4 antibody D2HUH5 93.0%
ARP62100 Gray short-tailed opossum ACKR4 antibody; Monodelphis domestica ACKR4 antibody F7GHG6 93.0%
ARP62099 Horse ACKR4 antibody; Equus caballus ACKR4 antibody F6VNE0 93.0%
ARP62100 Horse ACKR4 antibody; Equus caballus ACKR4 antibody F6VNE0 93.0%
ARP62099 Human ACKR4 antibody; Homo sapiens ACKR4 antibody Q9NPB9 100.0%
ARP62100 Human ACKR4 antibody; Homo sapiens ACKR4 antibody Q9NPB9 100.0%
ARP62099 Mouse ACKR4 antibody; Mus musculus ACKR4 antibody B2RU75 93.0%
ARP62099 Mouse ACKR4 antibody; Mus musculus ACKR4 antibody Q924I3 93.0%
ARP62100 Mouse ACKR4 antibody; Mus musculus ACKR4 antibody B2RU75 92.0%
ARP62100 Mouse ACKR4 antibody; Mus musculus ACKR4 antibody Q924I3 92.0%
ARP62100 Rabbit ACKR4 antibody; Oryctolagus cuniculus ACKR4 antibody G1TBW3 100.0%
ARP62099 Rabbit ACKR4 antibody; Oryctolagus cuniculus ACKR4 antibody G1TBW3 86.0%
ARP62100 Rat ACKR4 antibody; Rattus norvegicus ACKR4 antibody G3V9V6 92.0%
ARP62099 Rat ACKR4 antibody; Rattus norvegicus ACKR4 antibody G3V9V6 86.0%
ARP62099 Small-eared galago ACKR4 antibody; Otolemur garnettii ACKR4 antibody H0WX64 93.0%
ARP62100 Small-eared galago ACKR4 antibody; Otolemur garnettii ACKR4 antibody H0WX64 93.0%
ARP62099 Sumatran orangutan ACKR4 antibody; Pongo abelii ACKR4 antibody H2PBG1 100.0%
ARP62100 Sumatran orangutan ACKR4 antibody; Pongo abelii ACKR4 antibody H2PBG1 100.0%
ARP62100 Tasmanian devil ACKR4 antibody; Sarcophilus harrisii ACKR4 antibody G3WSD4 86.0%
ARP62099 Thirteen-lined ground squirrel ACKR4 antibody; Spermophilus tridecemlineatus ACKR4 antibody I3N5N6 93.0%
ARP62100 Thirteen-lined ground squirrel ACKR4 antibody; Spermophilus tridecemlineatus ACKR4 antibody I3N5N6 92.0%
ARP62099 White-tufted-ear marmoset ACKR4 antibody; Callithrix jacchus ACKR4 antibody F6VC38 100.0%
ARP62099 White-tufted-ear marmoset ACKR4 antibody; Callithrix jacchus ACKR4 antibody F7HLF4 100.0%
ARP62100 White-tufted-ear marmoset ACKR4 antibody; Callithrix jacchus ACKR4 antibody F6VC38 93.0%
ARP62100 White-tufted-ear marmoset ACKR4 antibody; Callithrix jacchus ACKR4 antibody F7HLF4 93.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas220351_at721_B_lymphoblasts8.1508.860Details
BioGPS Gene Atlas220351_atAdipocyte13.0008.860Details
BioGPS Gene Atlas220351_atAdrenalCortex11.9008.860Details
BioGPS Gene Atlas220351_atAdrenalgland7.4508.860Details
BioGPS Gene Atlas220351_atAmygdala7.9508.860Details
BioGPS Gene Atlas220351_atAppendix10.7508.860Details
BioGPS Gene Atlas220351_atAtrioventricularNode12.6508.860Details
BioGPS Gene Atlas220351_atBDCA4+_DentriticCells7.7508.860Details
BioGPS Gene Atlas220351_atBonemarrow9.5508.860Details
BioGPS Gene Atlas220351_atBronchialEpithelialCells7.8008.860Details
BioGPS Gene Atlas220351_atCD105+_Endothelial7.6008.860Details
BioGPS Gene Atlas220351_atCD14+_Monocytes8.5508.860Details
BioGPS Gene Atlas220351_atCD19+_BCells(neg._sel.)7.9508.860Details
BioGPS Gene Atlas220351_atCD33+_Myeloid9.7008.860Details
BioGPS Gene Atlas220351_atCD34+9.3008.860Details
BioGPS Gene Atlas220351_atCD4+_Tcells7.6008.860Details
BioGPS Gene Atlas220351_atCD56+_NKCells8.3508.860Details
BioGPS Gene Atlas220351_atCD71+_EarlyErythroid7.8008.860Details
BioGPS Gene Atlas220351_atCD8+_Tcells6.6508.860Details
BioGPS Gene Atlas220351_atCardiacMyocytes15.3508.860Details
BioGPS Gene Atlas220351_atCaudatenucleus7.3008.860Details
BioGPS Gene Atlas220351_atCerebellum6.5508.860Details
BioGPS Gene Atlas220351_atCerebellumPeduncles10.2008.860Details
BioGPS Gene Atlas220351_atCiliaryGanglion8.4008.860Details
BioGPS Gene Atlas220351_atCingulateCortex9.0008.860Details
BioGPS Gene Atlas220351_atColorectaladenocarcinoma8.0008.860Details
BioGPS Gene Atlas220351_atDorsalRootGanglion8.2508.860Details
BioGPS Gene Atlas220351_atFetalThyroid8.1508.860Details
BioGPS Gene Atlas220351_atFetalbrain7.2508.860Details
BioGPS Gene Atlas220351_atFetalliver7.4508.860Details
BioGPS Gene Atlas220351_atFetallung5.9508.860Details
BioGPS Gene Atlas220351_atGlobusPallidus6.9508.860Details
BioGPS Gene Atlas220351_atHeart15.9008.860Details
BioGPS Gene Atlas220351_atHypothalamus8.2508.860Details
BioGPS Gene Atlas220351_atKidney7.7508.860Details
BioGPS Gene Atlas220351_atLeukemia_chronicMyelogenousK-5627.2008.860Details
BioGPS Gene Atlas220351_atLeukemia_promyelocytic-HL-606.9508.860Details
BioGPS Gene Atlas220351_atLeukemialymphoblastic(MOLT-4)5.8008.860Details
BioGPS Gene Atlas220351_atLiver13.1508.860Details
BioGPS Gene Atlas220351_atLung8.4008.860Details
BioGPS Gene Atlas220351_atLymphnode6.2008.860Details
BioGPS Gene Atlas220351_atLymphoma_burkitts(Daudi)10.7508.860Details
BioGPS Gene Atlas220351_atLymphoma_burkitts(Raji)12.7508.860Details
BioGPS Gene Atlas220351_atMedullaOblongata7.4508.860Details
BioGPS Gene Atlas220351_atOccipitalLobe7.2508.860Details
BioGPS Gene Atlas220351_atOlfactoryBulb6.1508.860Details
BioGPS Gene Atlas220351_atOvary6.4008.860Details
BioGPS Gene Atlas220351_atPancreas7.2008.860Details
BioGPS Gene Atlas220351_atPancreaticIslet8.6008.860Details
BioGPS Gene Atlas220351_atParietalLobe9.4508.860Details
BioGPS Gene Atlas220351_atPituitary9.1008.860Details
BioGPS Gene Atlas220351_atPlacenta7.7008.860Details
BioGPS Gene Atlas220351_atPons8.8508.860Details
BioGPS Gene Atlas220351_atPrefrontalCortex9.8008.860Details
BioGPS Gene Atlas220351_atProstate9.0508.860Details
BioGPS Gene Atlas220351_atSalivarygland7.5008.860Details
BioGPS Gene Atlas220351_atSkeletalMuscle13.8008.860Details
BioGPS Gene Atlas220351_atSkin10.4008.860Details
BioGPS Gene Atlas220351_atSmoothMuscle9.1508.860Details
BioGPS Gene Atlas220351_atSpinalcord8.6508.860Details
BioGPS Gene Atlas220351_atSubthalamicNucleus7.9008.860Details
BioGPS Gene Atlas220351_atSuperiorCervicalGanglion15.6508.860Details
BioGPS Gene Atlas220351_atTemporalLobe7.9008.860Details
BioGPS Gene Atlas220351_atTestis6.9508.860Details
BioGPS Gene Atlas220351_atTestisGermCell6.6508.860Details
BioGPS Gene Atlas220351_atTestisIntersitial6.9008.860Details
BioGPS Gene Atlas220351_atTestisLeydigCell10.9008.860Details
BioGPS Gene Atlas220351_atTestisSeminiferousTubule6.9008.860Details
BioGPS Gene Atlas220351_atThalamus8.6008.860Details
BioGPS Gene Atlas220351_atThymus5.8508.860Details
BioGPS Gene Atlas220351_atThyroid9.9508.860Details
BioGPS Gene Atlas220351_atTongue10.0508.860Details
BioGPS Gene Atlas220351_atTonsil8.4508.860Details
BioGPS Gene Atlas220351_atTrachea6.8008.860Details
BioGPS Gene Atlas220351_atTrigeminalGanglion10.8508.860Details
BioGPS Gene Atlas220351_atUterus6.4008.860Details
BioGPS Gene Atlas220351_atUterusCorpus8.8508.860Details
BioGPS Gene Atlas220351_atWholeBlood8.8008.860Details
BioGPS Gene Atlas220351_atWholebrain6.5508.860Details
BioGPS Gene Atlas220351_atcolon8.2508.860Details
BioGPS Gene Atlas220351_atpineal_day9.5608.860Details
BioGPS Gene Atlas220351_atpineal_night9.2208.860Details
BioGPS Gene Atlas220351_atretina10.0258.860Details
BioGPS Gene Atlas220351_atsmall_intestine14.9508.860Details
BioGPS NCI60220351_at7868.4288.190Details
BioGPS NCI60220351_atA1726.8548.190Details
BioGPS NCI60220351_atA2047.7978.190Details
BioGPS NCI60220351_atA3618.0068.190Details
BioGPS NCI60220351_atA4987.6708.190Details
BioGPS NCI60220351_atA5498.1878.190Details
BioGPS NCI60220351_atACC39.5078.190Details
BioGPS NCI60220351_atACHN6.9978.190Details
BioGPS NCI60220351_atALVA3110.8758.190Details
BioGPS NCI60220351_atCAKI110.7108.190Details
BioGPS NCI60220351_atCCRT CEM16.6788.190Details
BioGPS NCI60220351_atCOLO20510.4578.190Details
BioGPS NCI60220351_atDLD17.4198.190Details
BioGPS NCI60220351_atDU1457.3808.190Details
BioGPS NCI60220351_atEKVX7.0218.190Details
BioGPS NCI60220351_atGM1338.4118.190Details
BioGPS NCI60220351_atGM16008.9658.190Details
BioGPS NCI60220351_atGM23138.2568.190Details
BioGPS NCI60220351_atGM23457.8788.190Details
BioGPS NCI60220351_atGM24938.8238.190Details
BioGPS NCI60220351_atGM9711.2588.190Details
BioGPS NCI60220351_atHCC29986.1488.190Details
BioGPS NCI60220351_atHCT1167.8688.190Details
BioGPS NCI60220351_atHCT156.5108.190Details
BioGPS NCI60220351_atHEK 293 T-rex11.1748.190Details
BioGPS NCI60220351_atHEK 293T7.6948.190Details
BioGPS NCI60220351_atHEK2937.7128.190Details
BioGPS NCI60220351_atHELA6.6908.190Details
BioGPS NCI60220351_atHEPG27.9818.190Details
BioGPS NCI60220351_atHL6010.0098.190Details
BioGPS NCI60220351_atHOP627.8618.190Details
BioGPS NCI60220351_atHOP927.2478.190Details
BioGPS NCI60220351_atHS578T7.6508.190Details
BioGPS NCI60220351_atHSG7.3458.190Details
BioGPS NCI60220351_atHT10807.4478.190Details
BioGPS NCI60220351_atHT2910.4748.190Details
BioGPS NCI60220351_atIGROV17.5118.190Details
BioGPS NCI60220351_atIOSE807.7778.190Details
BioGPS NCI60220351_atJURKAT7.7608.190Details
BioGPS NCI60220351_atK56211.2408.190Details
BioGPS NCI60220351_atKM129.0198.190Details
BioGPS NCI60220351_atLN186.5598.190Details
BioGPS NCI60220351_atLNCAP7.8438.190Details
BioGPS NCI60220351_atLOX IMVI7.6718.190Details
BioGPS NCI60220351_atM147.8948.190Details
BioGPS NCI60220351_atMALME 3M9.8958.190Details
BioGPS NCI60220351_atMCF77.5048.190Details
BioGPS NCI60220351_atMD MB2318.3968.190Details
BioGPS NCI60220351_atMDA MB43511.2988.190Details
BioGPS NCI60220351_atMOLT49.6168.190Details
BioGPS NCI60220351_atNCI 4608.3368.190Details
BioGPS NCI60220351_atNCI H2268.6228.190Details
BioGPS NCI60220351_atNCI H237.8438.190Details
BioGPS NCI60220351_atNCI H322M7.6268.190Details
BioGPS NCI60220351_atNCVADR RES6.5398.190Details
BioGPS NCI60220351_atOVCAR39.3708.190Details
BioGPS NCI60220351_atOVCAR47.8088.190Details
BioGPS NCI60220351_atOVCAR57.5878.190Details
BioGPS NCI60220351_atOVCAR86.7008.190Details
BioGPS NCI60220351_atPANC18.0298.190Details
BioGPS NCI60220351_atRL78.4118.190Details
BioGPS NCI60220351_atRPMI 82268.5488.190Details
BioGPS NCI60220351_atRS118469.7088.190Details
BioGPS NCI60220351_atRXF3937.8138.190Details
BioGPS NCI60220351_atSAOS27.9418.190Details
BioGPS NCI60220351_atSF2687.8468.190Details
BioGPS NCI60220351_atSF2957.4558.190Details
BioGPS NCI60220351_atSF5396.6788.190Details
BioGPS NCI60220351_atSHSYSY+RA7.1088.190Details
BioGPS NCI60220351_atSHSYSY-RA7.6648.190Details
BioGPS NCI60220351_atSKMEL27.7408.190Details
BioGPS NCI60220351_atSKMEL287.8698.190Details
BioGPS NCI60220351_atSKMEL56.6898.190Details
BioGPS NCI60220351_atSKOV38.8208.190Details
BioGPS NCI60220351_atSN12C7.5868.190Details
BioGPS NCI60220351_atSNB197.2108.190Details
BioGPS NCI60220351_atSNB757.6988.190Details
BioGPS NCI60220351_atSR9.1038.190Details
BioGPS NCI60220351_atSW6208.5618.190Details
BioGPS NCI60220351_atT248.2708.190Details
BioGPS NCI60220351_atT3M49.0558.190Details
BioGPS NCI60220351_atTK107.6378.190Details
BioGPS NCI60220351_atU1187.0978.190Details
BioGPS NCI60220351_atU1386.5868.190Details
BioGPS NCI60220351_atU20S7.3968.190Details
BioGPS NCI60220351_atU2517.6528.190Details
BioGPS NCI60220351_atU877.0718.190Details
BioGPS NCI60220351_atUACC2577.4008.190Details
BioGPS NCI60220351_atUACC628.2678.190Details
BioGPS NCI60220351_atUO317.1498.190Details
BioGPS NCI60220351_atZR75_18.9248.190Details
BioGPS NCI60220351_atastrocytes7.9258.190Details
BioGPS NCI60220351_athuh-78.4508.190Details