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Gene ID: 1238 | ACKR2 Antibody Resource


ACKR2 Antibody Resource
Gene Full Name: 
atypical chemokine receptor 2
Uniprot: 
O00590
Protein Name: 
atypical chemokine receptor 2
Nucleotide: 
NM_001296
Alias: 
D6;hD6;CCR9;CCBP2;CCR10;CMKBR9;
Ensembl: 
ENSG00000144648
Location: 
3p21.3
HPRD: 
09095
NCBI Gene: 
1238
MIM: 
602648

Summary: 
This gene encodes a beta chemokine receptor, which is predicted to be a seven transmembrane protein similar to G protein-coupled receptors. Chemokines and their receptor-mediated signal transduction are critical for the recruitment of effector immune cells to the inflammation site. This gene is expressed in a range of tissues and hemopoietic cells. The expression of this receptor in lymphatic endothelial cells and overexpression in vascular tumors suggested its function in chemokine-driven recirculation of leukocytes and possible chemokine effects on the development and growth of vascular tumors. This receptor appears to bind the majority of beta-chemokine family members; however, its specific function remains unknown. This gene is mapped to chromosome 3p21.3, a region that includes a cluster of chemokine receptor genes. [provided by RefSeq, Jul 2008]
Function: 
Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Acts as a receptor for chemokines including CCL2, CCL3, CCL3L1, CCL4, CCL5, CCL7, CCL8, CCL11, CCL13, CCL17, CCL22, CCL23, CCL24, SCYA2/MCP-1, SCY3/MIP-1-alpha, SCYA5/RANTES and SCYA7/MCP-3. Upon active ligand stimulation, activates a beta-arrestin 1 (ARRB1)-dependent, G protein-independent signaling pathway that results in the phosphorylation of the actin-binding protein cofilin (CFL1) through a RAC1-PAK1-LIMK1 signaling pathway. Activation of this pathway results in up-regulation of ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation. By scavenging chemokines in tissues, on the surfaces of lymphatic vessels, and in placenta, plays an essential role in the resolution (termination) of the inflammatory response and in the regulation of adaptive immune responses. Plays a major role in the immune silencing of macrophages during the resolution of inflammation. Acts as a regulator of inflammatory leukocyte interactions with lymphatic endothelial cells (LECs) and is required for immature/mature dendritic cells discrimination by LECs.
Subcellular location: 
Early endosome. Recycling endosome. Cell membrane; Multi-pass membrane protein. Note: Predominantly localizes to endocytic vesicles, and upon stimulation by the ligand is internalized via clathrin-coated pits. Once internalized, the ligand dissociates from the receptor, and is targeted to degradation while the receptor is recycled back to the cell membrane.
PTM: 
Disulfide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP30776_P050 CCBP2 antibody - N-terminal region (ARP30776_P050) Polyclonal Human IHC, WB 50ug $289 Details

Show all ACKR2 antibodies


Product Images
CCBP2 antibody - N-terminal region (ARP30776_P050) in Human Jurkat cells using Western Blot

Sample Type: Human Jurkat

CCBP2 antibody - N-terminal region (ARP30776_P050) in Human Muscle cells using Immunohistochemistry

Sample Type: Human Muscle


ACKR2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30776 Chimpanzee ACKR2 antibody; Pan troglodytes ACKR2 antibody H2R8C8 100.0%
ARP30776 Human ACKR2 antibody; Homo sapiens ACKR2 antibody O00590 100.0%
ARP30776 Rabbit ACKR2 antibody; Oryctolagus cuniculus ACKR2 antibody G1TG81 86.0%
ARP30776 Sumatran orangutan ACKR2 antibody; Pongo abelii ACKR2 antibody H2PB19 100.0%
ARP30776 Thirteen-lined ground squirrel ACKR2 antibody; Spermophilus tridecemlineatus ACKR2 antibody I3NBZ2 80.0%
ARP30776 White-tufted-ear marmoset ACKR2 antibody; Callithrix jacchus ACKR2 antibody F7HK24 79.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas206887_at721_B_lymphoblasts4.2503.480Details
BioGPS Gene Atlas206887_atAdipocyte3.3503.480Details
BioGPS Gene Atlas206887_atAdrenalCortex3.5003.480Details
BioGPS Gene Atlas206887_atAdrenalgland2.8503.480Details
BioGPS Gene Atlas206887_atAmygdala3.5503.480Details
BioGPS Gene Atlas206887_atAppendix3.3503.480Details
BioGPS Gene Atlas206887_atAtrioventricularNode3.0503.480Details
BioGPS Gene Atlas206887_atBDCA4+_DentriticCells3.8003.480Details
BioGPS Gene Atlas206887_atBonemarrow3.3003.480Details
BioGPS Gene Atlas206887_atBronchialEpithelialCells3.3503.480Details
BioGPS Gene Atlas206887_atCD105+_Endothelial3.4503.480Details
BioGPS Gene Atlas206887_atCD14+_Monocytes3.6003.480Details
BioGPS Gene Atlas206887_atCD19+_BCells(neg._sel.)3.6503.480Details
BioGPS Gene Atlas206887_atCD33+_Myeloid4.3503.480Details
BioGPS Gene Atlas206887_atCD34+4.3503.480Details
BioGPS Gene Atlas206887_atCD4+_Tcells3.7003.480Details
BioGPS Gene Atlas206887_atCD56+_NKCells4.0503.480Details
BioGPS Gene Atlas206887_atCD71+_EarlyErythroid3.2003.480Details
BioGPS Gene Atlas206887_atCD8+_Tcells3.3003.480Details
BioGPS Gene Atlas206887_atCardiacMyocytes4.2503.480Details
BioGPS Gene Atlas206887_atCaudatenucleus3.0503.480Details
BioGPS Gene Atlas206887_atCerebellum2.7503.480Details
BioGPS Gene Atlas206887_atCerebellumPeduncles3.8503.480Details
BioGPS Gene Atlas206887_atCiliaryGanglion2.3503.480Details
BioGPS Gene Atlas206887_atCingulateCortex3.4503.480Details
BioGPS Gene Atlas206887_atColorectaladenocarcinoma3.4003.480Details
BioGPS Gene Atlas206887_atDorsalRootGanglion2.9003.480Details
BioGPS Gene Atlas206887_atFetalThyroid3.3003.480Details
BioGPS Gene Atlas206887_atFetalbrain3.4003.480Details
BioGPS Gene Atlas206887_atFetalliver2.9003.480Details
BioGPS Gene Atlas206887_atFetallung2.9003.480Details
BioGPS Gene Atlas206887_atGlobusPallidus2.5003.480Details
BioGPS Gene Atlas206887_atHeart4.2503.480Details
BioGPS Gene Atlas206887_atHypothalamus3.7503.480Details
BioGPS Gene Atlas206887_atKidney2.7503.480Details
BioGPS Gene Atlas206887_atLeukemia_chronicMyelogenousK-5623.0503.480Details
BioGPS Gene Atlas206887_atLeukemia_promyelocytic-HL-603.0003.480Details
BioGPS Gene Atlas206887_atLeukemialymphoblastic(MOLT-4)2.7503.480Details
BioGPS Gene Atlas206887_atLiver4.4503.480Details
BioGPS Gene Atlas206887_atLung3.8003.480Details
BioGPS Gene Atlas206887_atLymphnode2.9503.480Details
BioGPS Gene Atlas206887_atLymphoma_burkitts(Daudi)4.3003.480Details
BioGPS Gene Atlas206887_atLymphoma_burkitts(Raji)4.7503.480Details
BioGPS Gene Atlas206887_atMedullaOblongata3.1503.480Details
BioGPS Gene Atlas206887_atOccipitalLobe3.1003.480Details
BioGPS Gene Atlas206887_atOlfactoryBulb2.7003.480Details
BioGPS Gene Atlas206887_atOvary2.2503.480Details
BioGPS Gene Atlas206887_atPancreas2.7003.480Details
BioGPS Gene Atlas206887_atPancreaticIslet3.6003.480Details
BioGPS Gene Atlas206887_atParietalLobe3.5503.480Details
BioGPS Gene Atlas206887_atPituitary4.0003.480Details
BioGPS Gene Atlas206887_atPlacenta4.7503.480Details
BioGPS Gene Atlas206887_atPons3.2003.480Details
BioGPS Gene Atlas206887_atPrefrontalCortex4.3003.480Details
BioGPS Gene Atlas206887_atProstate4.0503.480Details
BioGPS Gene Atlas206887_atSalivarygland2.7003.480Details
BioGPS Gene Atlas206887_atSkeletalMuscle5.5503.480Details
BioGPS Gene Atlas206887_atSkin2.7003.480Details
BioGPS Gene Atlas206887_atSmoothMuscle3.9003.480Details
BioGPS Gene Atlas206887_atSpinalcord3.6503.480Details
BioGPS Gene Atlas206887_atSubthalamicNucleus3.1003.480Details
BioGPS Gene Atlas206887_atSuperiorCervicalGanglion3.7503.480Details
BioGPS Gene Atlas206887_atTemporalLobe3.1003.480Details
BioGPS Gene Atlas206887_atTestis2.9503.480Details
BioGPS Gene Atlas206887_atTestisGermCell2.8503.480Details
BioGPS Gene Atlas206887_atTestisIntersitial2.8503.480Details
BioGPS Gene Atlas206887_atTestisLeydigCell3.3503.480Details
BioGPS Gene Atlas206887_atTestisSeminiferousTubule2.9503.480Details
BioGPS Gene Atlas206887_atThalamus3.4503.480Details
BioGPS Gene Atlas206887_atThymus2.7003.480Details
BioGPS Gene Atlas206887_atThyroid4.3003.480Details
BioGPS Gene Atlas206887_atTongue3.3003.480Details
BioGPS Gene Atlas206887_atTonsil3.3003.480Details
BioGPS Gene Atlas206887_atTrachea2.8003.480Details
BioGPS Gene Atlas206887_atTrigeminalGanglion3.4003.480Details
BioGPS Gene Atlas206887_atUterus2.8003.480Details
BioGPS Gene Atlas206887_atUterusCorpus4.5003.480Details
BioGPS Gene Atlas206887_atWholeBlood3.7503.480Details
BioGPS Gene Atlas206887_atWholebrain2.9503.480Details
BioGPS Gene Atlas206887_atcolon3.4003.480Details
BioGPS Gene Atlas206887_atpineal_day4.2403.480Details
BioGPS Gene Atlas206887_atpineal_night4.1203.480Details
BioGPS Gene Atlas206887_atretina4.1503.480Details
BioGPS Gene Atlas206887_atsmall_intestine3.2503.480Details
BioGPS NCI60206887_at7863.4123.360Details
BioGPS NCI60206887_atA1723.2913.360Details
BioGPS NCI60206887_atA2043.3143.360Details
BioGPS NCI60206887_atA3613.3773.360Details
BioGPS NCI60206887_atA4983.3653.360Details
BioGPS NCI60206887_atA5493.3903.360Details
BioGPS NCI60206887_atACC33.4383.360Details
BioGPS NCI60206887_atACHN3.2143.360Details
BioGPS NCI60206887_atALVA313.4263.360Details
BioGPS NCI60206887_atCAKI13.4253.360Details
BioGPS NCI60206887_atCCRT CEM3.5743.360Details
BioGPS NCI60206887_atCOLO2053.3463.360Details
BioGPS NCI60206887_atDLD13.3233.360Details
BioGPS NCI60206887_atDU1453.2813.360Details
BioGPS NCI60206887_atEKVX3.2803.360Details
BioGPS NCI60206887_atGM1333.4253.360Details
BioGPS NCI60206887_atGM16003.4743.360Details
BioGPS NCI60206887_atGM23133.4033.360Details
BioGPS NCI60206887_atGM23453.3633.360Details
BioGPS NCI60206887_atGM24933.4663.360Details
BioGPS NCI60206887_atGM973.5953.360Details
BioGPS NCI60206887_atHCC29983.2073.360Details
BioGPS NCI60206887_atHCT1163.3333.360Details
BioGPS NCI60206887_atHCT153.2583.360Details
BioGPS NCI60206887_atHEK 293 T-rex3.3913.360Details
BioGPS NCI60206887_atHEK 293T3.3743.360Details
BioGPS NCI60206887_atHEK2933.3743.360Details
BioGPS NCI60206887_atHELA3.2593.360Details
BioGPS NCI60206887_atHEPG23.3403.360Details
BioGPS NCI60206887_atHL603.3963.360Details
BioGPS NCI60206887_atHOP623.3603.360Details
BioGPS NCI60206887_atHOP923.2993.360Details
BioGPS NCI60206887_atHS578T3.3373.360Details
BioGPS NCI60206887_atHSG3.2913.360Details
BioGPS NCI60206887_atHT10803.3423.360Details
BioGPS NCI60206887_atHT293.5043.360Details
BioGPS NCI60206887_atIGROV13.3283.360Details
BioGPS NCI60206887_atIOSE803.3373.360Details
BioGPS NCI60206887_atJURKAT3.3473.360Details
BioGPS NCI60206887_atK5623.4843.360Details
BioGPS NCI60206887_atKM123.4343.360Details
BioGPS NCI60206887_atLN183.2803.360Details
BioGPS NCI60206887_atLNCAP3.3433.360Details
BioGPS NCI60206887_atLOX IMVI3.3463.360Details
BioGPS NCI60206887_atM143.3163.360Details
BioGPS NCI60206887_atMALME 3M3.4663.360Details
BioGPS NCI60206887_atMCF73.2743.360Details
BioGPS NCI60206887_atMD MB2313.3683.360Details
BioGPS NCI60206887_atMDA MB4353.4393.360Details
BioGPS NCI60206887_atMOLT43.3953.360Details
BioGPS NCI60206887_atNCI 4603.4073.360Details
BioGPS NCI60206887_atNCI H2263.4043.360Details
BioGPS NCI60206887_atNCI H233.3453.360Details
BioGPS NCI60206887_atNCI H322M3.3643.360Details
BioGPS NCI60206887_atNCVADR RES3.2853.360Details
BioGPS NCI60206887_atOVCAR33.4313.360Details
BioGPS NCI60206887_atOVCAR43.3403.360Details
BioGPS NCI60206887_atOVCAR53.3273.360Details
BioGPS NCI60206887_atOVCAR83.2233.360Details
BioGPS NCI60206887_atPANC13.3803.360Details
BioGPS NCI60206887_atRL73.3903.360Details
BioGPS NCI60206887_atRPMI 82263.3743.360Details
BioGPS NCI60206887_atRS118463.4593.360Details
BioGPS NCI60206887_atRXF3933.3363.360Details
BioGPS NCI60206887_atSAOS23.3863.360Details
BioGPS NCI60206887_atSF2683.3563.360Details
BioGPS NCI60206887_atSF2953.3133.360Details
BioGPS NCI60206887_atSF5393.2283.360Details
BioGPS NCI60206887_atSHSYSY+RA3.2833.360Details
BioGPS NCI60206887_atSHSYSY-RA3.3253.360Details
BioGPS NCI60206887_atSKMEL23.3463.360Details
BioGPS NCI60206887_atSKMEL283.3543.360Details
BioGPS NCI60206887_atSKMEL53.2943.360Details
BioGPS NCI60206887_atSKOV33.3923.360Details
BioGPS NCI60206887_atSN12C3.3393.360Details
BioGPS NCI60206887_atSNB193.2653.360Details
BioGPS NCI60206887_atSNB753.3463.360Details
BioGPS NCI60206887_atSR3.3963.360Details
BioGPS NCI60206887_atSW6203.3513.360Details
BioGPS NCI60206887_atT243.3953.360Details
BioGPS NCI60206887_atT3M43.4463.360Details
BioGPS NCI60206887_atTK103.3353.360Details
BioGPS NCI60206887_atU1183.3393.360Details
BioGPS NCI60206887_atU1383.2853.360Details
BioGPS NCI60206887_atU20S3.3593.360Details
BioGPS NCI60206887_atU2513.3333.360Details
BioGPS NCI60206887_atU873.3253.360Details
BioGPS NCI60206887_atUACC2573.3253.360Details
BioGPS NCI60206887_atUACC623.3843.360Details
BioGPS NCI60206887_atUO313.2813.360Details
BioGPS NCI60206887_atZR75_13.3883.360Details
BioGPS NCI60206887_atastrocytes3.4163.360Details
BioGPS NCI60206887_athuh-73.4263.360Details