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Gene ID: 340485 | ACER2 Antibody Resource


ACER2 Antibody Resource
Gene Full Name: 
alkaline ceramidase 2
Uniprot: 
Q5QJU3
Protein Name: 
alkaline ceramidase 2
Nucleotide: 
XM_005251447
Alias: 
ASAH3L;ALKCDase2;
Ensembl: 
Location: 
9p22.1
HPRD: 
16512
NCBI Gene: 
340485
MIM: 
613492

Summary: 
The sphingolipid metabolite sphingosine-1-phosphate promotes cell proliferation and survival, whereas its precursor, sphingosine, has the opposite effect. The ceramidase ACER2 hydrolyzes very long chain ceramides to generate sphingosine (Xu et al., 2006 [PubMed 16940153]).[supplied by OMIM, Jul 2010]
Function: 
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. Unsaturated long-chain ceramides are the best substrates, saturated long-chain ceramides and unsaturated very long-chain ceramides are good substrates, whereas saturated very long-chain ceramides and short-chain ceramides were poor substrates. The substrate preference is D-erythro-C(18:1)-, C(20:1)-, C(20:4)-ceramide > D-erythro-C(16:0)-, C(18:0), C(20:0)-ceramide > D-erythro-C(24:1)-ceramide > D-erythro-C(12:0)-ceramide, D-erythro-C(14:0)-ceramides > D-erythro-C(24:0)-ceramide > D-erythro-C(6:0)-ceramide. Inhibits the maturation of protein glycosylation in the Golgi complex, including that of integrin beta-1 (ITGB1) and of LAMP1, by increasing the levels of sphingosine. Inhibits cell adhesion by reducing the level of ITGB1 in the cell surface. May have a role in cell proliferation and apoptosis that seems to depend on the balance between sphingosine and sphingosine-1-phosphate.
Subcellular location: 
Golgi apparatus membrane; Multi-pass membrane protein .
PTM: 
Glycoprotein;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP66122_P050 ACER2 Antibody - middle region (ARP66122_P050) Human WB 50ug $289 Details
Polyclonal Antibody ARP66121_P050 ACER2 Antibody (ARP66121_P050) Polyclonal Not tested 50 ug $125 Details
Polyclonal Antibody OAEC02483 ASAH3L Antibody (OAEC02483) Human; Mouse WB: 1:500~1:1000 ELISA: 1:5000 100ug $229 Details
Polyclonal Antibody OAAF03260 ACER2 Antibody (OAAF03260) Polyclonal Human, Mouse WB, ELISA 100 ug $229 Details

Show all ACER2 antibodies


Product Images
ACER2 Antibody - middle region (ARP66122_P050) in Human Fetal Lung cells using Western Blot

Sample Type: Human Fetal Lung

ACER2 Antibody (OAAF03260) in COS7 cells using Western Blot

Sample Type: COS7


ACER2 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP66121 Bovine ACER2 antibody; Bos taurus ACER2 antibody E1B8N2 100.0%
ARP66122 Bovine ACER2 antibody; Bos taurus ACER2 antibody E1B8N2 100.0%
ARP66122 Cat ACER2 antibody; Felis catus ACER2 antibody M3VYQ1 100.0%
ARP66121 Cat ACER2 antibody; Felis catus ACER2 antibody M3VYQ1 86.0%
ARP66122 Channel catfish ACER2 antibody; Ictalurus punctatus ACER2 antibody E3TG15 79.0%
ARP66121 Chicken ACER2 antibody; Gallus gallus ACER2 antibody E1C990 85.0%
ARP66122 Chicken ACER2 antibody; Gallus gallus ACER2 antibody E1C990 79.0%
ARP66121 Chimpanzee ACER2 antibody; Pan troglodytes ACER2 antibody H2QX17 100.0%
ARP66122 Chimpanzee ACER2 antibody; Pan troglodytes ACER2 antibody H2QX17 100.0%
ARP66121 Chinese softshell turtle ACER2 antibody; Pelodiscus sinensis ACER2 antibody K7FLJ2 92.0%
ARP66122 Chinese softshell turtle ACER2 antibody; Pelodiscus sinensis ACER2 antibody K7FLJ2 86.0%
ARP66121 Collared flycatcher ACER2 antibody; Ficedula albicollis ACER2 antibody U3JKA3 85.0%
ARP66122 Collared flycatcher ACER2 antibody; Ficedula albicollis ACER2 antibody U3JKA3 79.0%
ARP66122 Dog ACER2 antibody; Canis familiaris ACER2 antibody J9NTZ7 93.0%
ARP66121 Dog ACER2 antibody; Canis familiaris ACER2 antibody J9NTZ7 86.0%
ARP66121 Domestic duck ACER2 antibody; Anas platyrhynchos ACER2 antibody R0LZP2 85.0%
ARP66122 Domestic duck ACER2 antibody; Anas platyrhynchos ACER2 antibody R0LZP2 79.0%
ARP66122 Duckbill platypus ACER2 antibody; Ornithorhynchus anatinus ACER2 antibody F6VJK4 86.0%
ARP66122 European domestic ferret ACER2 antibody; Mustela putorius furo ACER2 antibody M3YX44 93.0%
ARP66121 European domestic ferret ACER2 antibody; Mustela putorius furo ACER2 antibody M3YX44 86.0%
ARP66122 Giant panda ACER2 antibody; Ailuropoda melanoleuca ACER2 antibody D2H9N1 93.0%
ARP66121 Giant panda ACER2 antibody; Ailuropoda melanoleuca ACER2 antibody D2H9N1 86.0%
ARP66122 Gray short-tailed opossum ACER2 antibody; Monodelphis domestica ACER2 antibody F6VW29 93.0%
ARP66121 Gray short-tailed opossum ACER2 antibody; Monodelphis domestica ACER2 antibody F6VW29 86.0%
ARP66122 Horse ACER2 antibody; Equus caballus ACER2 antibody F6XSP1 100.0%
ARP66121 Horse ACER2 antibody; Equus caballus ACER2 antibody F6XSP1 79.0%
ARP66121 Human ACER2 antibody; Homo sapiens ACER2 antibody Q5QJU3-2 100.0%
ARP66122 Human ACER2 antibody; Homo sapiens ACER2 antibody Q5QJU3-2 100.0%
ARP66122 Human ACER2 antibody; Homo sapiens ACER2 antibody Q5QJU3-3 100.0%
ARP66121 Human ACER2 antibody; Homo sapiens ACER2 antibody Q5QJU3 100.0%
ARP66122 Human ACER2 antibody; Homo sapiens ACER2 antibody Q5QJU3 100.0%
ARP66122 Mouse ACER2 antibody; Mus musculus ACER2 antibody Q8VD53-2 100.0%
ARP66122 Mouse ACER2 antibody; Mus musculus ACER2 antibody Q8VD53 100.0%
ARP66121 Mouse ACER2 antibody; Mus musculus ACER2 antibody Q8VD53-2 86.0%
ARP66121 Mouse ACER2 antibody; Mus musculus ACER2 antibody Q8VD53 86.0%
ARP66122 Pig ACER2 antibody; Sus scrofa ACER2 antibody F1SNG0 100.0%
ARP66121 Pig ACER2 antibody; Sus scrofa ACER2 antibody F1SNG0 93.0%
ARP66122 Rabbit ACER2 antibody; Oryctolagus cuniculus ACER2 antibody G1T3A8 100.0%
ARP66121 Rabbit ACER2 antibody; Oryctolagus cuniculus ACER2 antibody G1T3A8 93.0%
ARP66122 Rat ACER2 antibody; Rattus norvegicus ACER2 antibody D3ZNW4 100.0%
ARP66121 Rat ACER2 antibody; Rattus norvegicus ACER2 antibody D3ZNW4 86.0%
ARP66121 Rhesus macaque ACER2 antibody; Macaca mulatta ACER2 antibody H9F8S7 100.0%
ARP66122 Rhesus macaque ACER2 antibody; Macaca mulatta ACER2 antibody H9F8S7 100.0%
ARP66122 Small-eared galago ACER2 antibody; Otolemur garnettii ACER2 antibody H0XEZ3 100.0%
ARP66121 Small-eared galago ACER2 antibody; Otolemur garnettii ACER2 antibody H0XEZ3 93.0%
ARP66121 Sumatran orangutan ACER2 antibody; Pongo abelii ACER2 antibody H2PS33 93.0%
ARP66122 Sumatran orangutan ACER2 antibody; Pongo abelii ACER2 antibody H2PS33 93.0%
ARP66122 Thirteen-lined ground squirrel ACER2 antibody; Spermophilus tridecemlineatus ACER2 antibody I3N422 100.0%
ARP66121 Thirteen-lined ground squirrel ACER2 antibody; Spermophilus tridecemlineatus ACER2 antibody I3N422 86.0%
ARP66121 Western clawed frog ACER2 antibody; Xenopus tropicalis ACER2 antibody B5DE59 85.0%
ARP66121 White-tufted-ear marmoset ACER2 antibody; Callithrix jacchus ACER2 antibody F7IBP9 100.0%
ARP66121 White-tufted-ear marmoset ACER2 antibody; Callithrix jacchus ACER2 antibody U3CY90 100.0%
ARP66122 White-tufted-ear marmoset ACER2 antibody; Callithrix jacchus ACER2 antibody U3CY90 100.0%
ARP66122 White-tufted-ear marmoset ACER2 antibody; Callithrix jacchus ACER2 antibody F7IBP9 88.0%

Tissue & Cell Line Gene Expression Data