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Gene ID: 125981 | ACER1 Antibody Resource


ACER1 Antibody Resource
Gene Full Name: 
alkaline ceramidase 1
Uniprot: 
Q8TDN7
Protein Name: 
alkaline ceramidase 1
Nucleotide: 
NM_133492
Alias: 
ASAH3;ALKCDase1;
Ensembl: 
Location: 
19p13.3
HPRD: 
12496
NCBI Gene: 
125981
MIM: 
613491

Summary: 
Ceramides are synthesized during epidermal differentiation and accumulate within the interstices of the stratum corneum, where they represent critical components of the epidermal permeability barrier. Excess cellular ceramide can trigger antimitogenic signals and induce apoptosis, and the ceramide metabolites sphingosine and sphingosine-1-phosphate (S1P) are important bioregulatory molecules. Ceramide hydrolysis in the nucleated cell layers regulates keratinocyte proliferation and apoptosis in response to external stress. Ceramide hydrolysis also occurs at the stratum corneum, releasing free sphingoid base that functions as an endogenous antimicrobial agent. ACER1 is highly expressed in epidermis and catalyzes the hydrolysis of very long chain ceramides to generate sphingosine (Houben et al., 2006 [PubMed 16477081]; Sun et al., 2008 [PubMed 17713573]).[supplied by OMIM, Jul 2010]
Function: 
Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid at an optimal pH of 8.0. Has a highly restricted substrate specificity for the natural stereoisomer of ceramide with D-erythro-sphingosine but not D-ribo-phytosphingosine or D-erythro-dihydrosphingosine as a backbone. May have a role in regulating the levels of bioactive lipids ceramide and sphingosine 1-phosphate, as well as complex sphingolipids .
Subcellular location: 
Endoplasmic reticulum membrane; Multi-pass membrane protein.
PTM: 
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody ARP60813_P050 ACER1 antibody - C-terminal region (ARP60813_P050) Polyclonal Human WB 50ug $289 Details
Polyclonal Antibody ARP60812_P050 ACER1 antibody - C-terminal region (ARP60812_P050) Polyclonal Bovine, Dog, Guinea pig, Human, Rabbit WB 50ug $289 Details
Polyclonal Antibody OAAB14193 ACER1 antibody - C - terminal region (OAAB14193) Human WB 400ul $289 Details
Polyclonal Antibody OAAF03259 ACER1 Antibody (OAAF03259) Polyclonal Human WB, ELISA 100 ug $229 Details

Show all ACER1 antibodies


Product Images
ACER1 antibody - C-terminal region (ARP60812_P050) in Human HCT15 cells using Western Blot

Sample Type: Human HCT15

ACER1 antibody - C-terminal region (ARP60813_P050) in Human Fetal Brain cells using Western Blot

Sample Type: Human Fetal Brain

ACER1 antibody - C - terminal region (OAAB14193) in Jurkat cells using Western Blot

Sample Type: Jurkat

ACER1 Antibody (OAAF03259) in HepG2 cells using Western Blot

Sample Type: HepG2


ACER1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP60812 Cat ACER1 antibody; Felis catus ACER1 antibody M3WH30 85.0%
ARP60813 Cat ACER1 antibody; Felis catus ACER1 antibody M3WH30 79.0%
ARP60812 Chimpanzee ACER1 antibody; Pan troglodytes ACER1 antibody H2QF43 100.0%
ARP60813 Chimpanzee ACER1 antibody; Pan troglodytes ACER1 antibody H2QF43 100.0%
ARP60812 Dog ACER1 antibody; Canis familiaris ACER1 antibody F1PTY8 92.0%
ARP60812 Dog ACER1 antibody; Canis familiaris ACER1 antibody F1PZB6 92.0%
ARP60812 European domestic ferret ACER1 antibody; Mustela putorius furo ACER1 antibody M3Y589 92.0%
ARP60812 Giant panda ACER1 antibody; Ailuropoda melanoleuca ACER1 antibody G1LK17 85.0%
ARP60812 Human ACER1 antibody; Homo sapiens ACER1 antibody Q8TDN7 100.0%
ARP60813 Human ACER1 antibody; Homo sapiens ACER1 antibody Q8TDN7 100.0%
ARP60812 Pig ACER1 antibody; Sus scrofa ACER1 antibody I3LJ54 85.0%
ARP60812 Rabbit ACER1 antibody; Oryctolagus cuniculus ACER1 antibody G1TNB0 86.0%
ARP60812 Rhesus macaque ACER1 antibody; Macaca mulatta ACER1 antibody F6U4Z7 100.0%
ARP60813 Rhesus macaque ACER1 antibody; Macaca mulatta ACER1 antibody F6U4Z7 93.0%
ARP60812 Small-eared galago ACER1 antibody; Otolemur garnettii ACER1 antibody H0WJD2 79.0%
ARP60812 Sumatran orangutan ACER1 antibody; Pongo abelii ACER1 antibody H2NX75 100.0%
ARP60813 Sumatran orangutan ACER1 antibody; Pongo abelii ACER1 antibody H2NX75 93.0%
ARP60812 Thirteen-lined ground squirrel ACER1 antibody; Spermophilus tridecemlineatus ACER1 antibody I3M086 92.0%
ARP60813 Thirteen-lined ground squirrel ACER1 antibody; Spermophilus tridecemlineatus ACER1 antibody I3M086 79.0%
ARP60812 White-tufted-ear marmoset ACER1 antibody; Callithrix jacchus ACER1 antibody F6WT27 100.0%
ARP60813 White-tufted-ear marmoset ACER1 antibody; Callithrix jacchus ACER1 antibody F6WT27 93.0%

Tissue & Cell Line Gene Expression Data