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Gene ID: 15 | AANAT Antibody Resource


AANAT Antibody Resource
Gene Full Name: 
aralkylamine N-acetyltransferase
Uniprot: 
Q16613
Protein Name: 
serotonin N-acetyltransferase
Nucleotide: 
NM_001166579
Alias: 
DSPS;SNAT;
Ensembl: 
ENSG00000129673
Location: 
17q25.1
HPRD: 
02974
NCBI Gene: 
15
MIM: 
600950

Summary: 
The protein encoded by this gene belongs to the acetyltransferase superfamily. It is the penultimate enzyme in melatonin synthesis and controls the night/day rhythm in melatonin production in the vertebrate pineal gland. Melatonin is essential for the function of the circadian clock that influences activity and sleep. This enzyme is regulated by cAMP-dependent phosphorylation that promotes its interaction with 14-3-3 proteins and thus protects the enzyme against proteasomal degradation. This gene may contribute to numerous genetic diseases such as delayed sleep phase syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2009]
Function: 
Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin.
Subcellular location: 
Cytoplasm .
PTM: 
Phosphoprotein;
Disease: 
Delayed sleep phase syndrome (DSPS) [MIM:614163]: A circadian rhythm sleep disorder characterized by sleep-onset insomnia and difficulty in awakening at the desired time. Patients with DSPS have chronic difficulty in adjusting their sleep-onset and wake-up times to occupational, school, and social activities. Note: Disease susceptibility may be associated with variations affecting the gene represented in this entry. Susceptibility to delayed sleep phase syndrome can be conferred by variant Thr-129. Thr-129 shows a significantly higher frequency in affected individuals than in healthy controls.
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB06222 AANAT antibody - N-terminal region (OAAB06222) Human WB, ELISA 400ul $289 Details
Polyclonal Antibody ARP30418_P050 AANAT Antibody (ARP30418_P050) Polyclonal Human Not tested 50 ug $125 Details

Show all AANAT antibodies


Product Images
AANAT antibody - N-terminal region (OAAB06222) in Y79 cells using Western Blot

Sample Type: Y79


AANAT Protocols

Publications

Related Gene Trend Categories

Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP30418 Chimpanzee AANAT antibody; Pan troglodytes AANAT antibody Q5IS55 92.0%
ARP30418 Human AANAT antibody; Homo sapiens AANAT antibody F1T0I5 100.0%
ARP30418 Human AANAT antibody; Homo sapiens AANAT antibody J3KMZ5 100.0%
ARP30418 Human AANAT antibody; Homo sapiens AANAT antibody K7ERF6 100.0%
ARP30418 Human AANAT antibody; Homo sapiens AANAT antibody K7ESH7 100.0%
ARP30418 Human AANAT antibody; Homo sapiens AANAT antibody Q16613 100.0%
ARP30418 Human AANAT antibody; Homo sapiens AANAT antibody Q9H3T0 100.0%
ARP30418 Rhesus macaque AANAT antibody; Macaca mulatta AANAT antibody O97756 93.0%
ARP30418 Small-eared galago AANAT antibody; Otolemur garnettii AANAT antibody H0XWM7 91.0%
ARP30418 Sumatran orangutan AANAT antibody; Pongo abelii AANAT antibody H2NUT6 100.0%

Tissue & Cell Line Gene Expression Data
Data SourceProbesetSampleAvgMeanMore Info
BioGPS Gene Atlas207225_at721_B_lymphoblasts4.40024.400Details
BioGPS Gene Atlas207225_atAdipocyte3.45024.400Details
BioGPS Gene Atlas207225_atAdrenalCortex3.80024.400Details
BioGPS Gene Atlas207225_atAdrenalgland2.95024.400Details
BioGPS Gene Atlas207225_atAmygdala3.70024.400Details
BioGPS Gene Atlas207225_atAppendix3.50024.400Details
BioGPS Gene Atlas207225_atAtrioventricularNode2.65024.400Details
BioGPS Gene Atlas207225_atBDCA4+_DentriticCells3.85024.400Details
BioGPS Gene Atlas207225_atBonemarrow3.75024.400Details
BioGPS Gene Atlas207225_atBronchialEpithelialCells3.45024.400Details
BioGPS Gene Atlas207225_atCD105+_Endothelial3.55024.400Details
BioGPS Gene Atlas207225_atCD14+_Monocytes3.75024.400Details
BioGPS Gene Atlas207225_atCD19+_BCells(neg._sel.)3.75024.400Details
BioGPS Gene Atlas207225_atCD33+_Myeloid4.45024.400Details
BioGPS Gene Atlas207225_atCD34+4.40024.400Details
BioGPS Gene Atlas207225_atCD4+_Tcells3.80024.400Details
BioGPS Gene Atlas207225_atCD56+_NKCells4.30024.400Details
BioGPS Gene Atlas207225_atCD71+_EarlyErythroid3.35024.400Details
BioGPS Gene Atlas207225_atCD8+_Tcells3.30024.400Details
BioGPS Gene Atlas207225_atCardiacMyocytes4.45024.400Details
BioGPS Gene Atlas207225_atCaudatenucleus3.15024.400Details
BioGPS Gene Atlas207225_atCerebellum2.80024.400Details
BioGPS Gene Atlas207225_atCerebellumPeduncles3.95024.400Details
BioGPS Gene Atlas207225_atCiliaryGanglion2.45024.400Details
BioGPS Gene Atlas207225_atCingulateCortex3.55024.400Details
BioGPS Gene Atlas207225_atColorectaladenocarcinoma3.50024.400Details
BioGPS Gene Atlas207225_atDorsalRootGanglion2.65024.400Details
BioGPS Gene Atlas207225_atFetalThyroid3.40024.400Details
BioGPS Gene Atlas207225_atFetalbrain3.50024.400Details
BioGPS Gene Atlas207225_atFetalliver3.05024.400Details
BioGPS Gene Atlas207225_atFetallung2.85024.400Details
BioGPS Gene Atlas207225_atGlobusPallidus2.65024.400Details
BioGPS Gene Atlas207225_atHeart4.45024.400Details
BioGPS Gene Atlas207225_atHypothalamus3.80024.400Details
BioGPS Gene Atlas207225_atKidney2.80024.400Details
BioGPS Gene Atlas207225_atLeukemia_chronicMyelogenousK-5623.15024.400Details
BioGPS Gene Atlas207225_atLeukemia_promyelocytic-HL-603.10024.400Details
BioGPS Gene Atlas207225_atLeukemialymphoblastic(MOLT-4)2.80024.400Details
BioGPS Gene Atlas207225_atLiver4.90024.400Details
BioGPS Gene Atlas207225_atLung3.85024.400Details
BioGPS Gene Atlas207225_atLymphnode3.05024.400Details
BioGPS Gene Atlas207225_atLymphoma_burkitts(Daudi)4.50024.400Details
BioGPS Gene Atlas207225_atLymphoma_burkitts(Raji)4.90024.400Details
BioGPS Gene Atlas207225_atMedullaOblongata3.20024.400Details
BioGPS Gene Atlas207225_atOccipitalLobe3.15024.400Details
BioGPS Gene Atlas207225_atOlfactoryBulb2.75024.400Details
BioGPS Gene Atlas207225_atOvary2.35024.400Details
BioGPS Gene Atlas207225_atPancreas2.80024.400Details
BioGPS Gene Atlas207225_atPancreaticIslet3.70024.400Details
BioGPS Gene Atlas207225_atParietalLobe3.65024.400Details
BioGPS Gene Atlas207225_atPituitary4.10024.400Details
BioGPS Gene Atlas207225_atPlacenta3.60024.400Details
BioGPS Gene Atlas207225_atPons3.30024.400Details
BioGPS Gene Atlas207225_atPrefrontalCortex4.40024.400Details
BioGPS Gene Atlas207225_atProstate4.20024.400Details
BioGPS Gene Atlas207225_atSalivarygland2.80024.400Details
BioGPS Gene Atlas207225_atSkeletalMuscle4.20024.400Details
BioGPS Gene Atlas207225_atSkin2.65024.400Details
BioGPS Gene Atlas207225_atSmoothMuscle4.00024.400Details
BioGPS Gene Atlas207225_atSpinalcord3.75024.400Details
BioGPS Gene Atlas207225_atSubthalamicNucleus3.20024.400Details
BioGPS Gene Atlas207225_atSuperiorCervicalGanglion3.95024.400Details
BioGPS Gene Atlas207225_atTemporalLobe3.20024.400Details
BioGPS Gene Atlas207225_atTestis3.00024.400Details
BioGPS Gene Atlas207225_atTestisGermCell2.95024.400Details
BioGPS Gene Atlas207225_atTestisIntersitial2.95024.400Details
BioGPS Gene Atlas207225_atTestisLeydigCell3.45024.400Details
BioGPS Gene Atlas207225_atTestisSeminiferousTubule3.00024.400Details
BioGPS Gene Atlas207225_atThalamus3.55024.400Details
BioGPS Gene Atlas207225_atThymus2.75024.400Details
BioGPS Gene Atlas207225_atThyroid4.45024.400Details
BioGPS Gene Atlas207225_atTongue3.40024.400Details
BioGPS Gene Atlas207225_atTonsil3.40024.400Details
BioGPS Gene Atlas207225_atTrachea2.90024.400Details
BioGPS Gene Atlas207225_atTrigeminalGanglion3.45024.400Details
BioGPS Gene Atlas207225_atUterus2.80024.400Details
BioGPS Gene Atlas207225_atUterusCorpus3.15024.400Details
BioGPS Gene Atlas207225_atWholeBlood3.85024.400Details
BioGPS Gene Atlas207225_atWholebrain2.95024.400Details
BioGPS Gene Atlas207225_atcolon3.50024.400Details
BioGPS Gene Atlas207225_atpineal_day389.50024.400Details
BioGPS Gene Atlas207225_atpineal_night353.56024.400Details
BioGPS Gene Atlas207225_atretina4.30024.400Details
BioGPS Gene Atlas207225_atsmall_intestine3.40024.400Details
BioGPS NCI60207225_at7864.0563.980Details
BioGPS NCI60207225_atA1723.8553.980Details
BioGPS NCI60207225_atA2043.9473.980Details
BioGPS NCI60207225_atA3614.0033.980Details
BioGPS NCI60207225_atA4983.9783.980Details
BioGPS NCI60207225_atA5494.0153.980Details
BioGPS NCI60207225_atACC34.2563.980Details
BioGPS NCI60207225_atACHN3.7823.980Details
BioGPS NCI60207225_atALVA314.2073.980Details
BioGPS NCI60207225_atCAKI14.0883.980Details
BioGPS NCI60207225_atCCRT CEM4.3053.980Details
BioGPS NCI60207225_atCOLO2053.9873.980Details
BioGPS NCI60207225_atDLD13.9273.980Details
BioGPS NCI60207225_atDU1453.9203.980Details
BioGPS NCI60207225_atEKVX3.8933.980Details
BioGPS NCI60207225_atGM1334.0693.980Details
BioGPS NCI60207225_atGM16004.1383.980Details
BioGPS NCI60207225_atGM23134.0273.980Details
BioGPS NCI60207225_atGM23453.9953.980Details
BioGPS NCI60207225_atGM24934.1473.980Details
BioGPS NCI60207225_atGM974.2763.980Details
BioGPS NCI60207225_atHCC29983.7363.980Details
BioGPS NCI60207225_atHCT1163.9433.980Details
BioGPS NCI60207225_atHCT153.8053.980Details
BioGPS NCI60207225_atHEK 293 T-rex4.0243.980Details
BioGPS NCI60207225_atHEK 293T3.9603.980Details
BioGPS NCI60207225_atHEK2933.9593.980Details
BioGPS NCI60207225_atHELA3.6733.980Details
BioGPS NCI60207225_atHEPG23.9633.980Details
BioGPS NCI60207225_atHL604.0323.980Details
BioGPS NCI60207225_atHOP623.9833.980Details
BioGPS NCI60207225_atHOP923.9153.980Details
BioGPS NCI60207225_atHS578T3.9393.980Details
BioGPS NCI60207225_atHSG3.8753.980Details
BioGPS NCI60207225_atHT10803.9603.980Details
BioGPS NCI60207225_atHT294.2723.980Details
BioGPS NCI60207225_atIGROV13.9393.980Details
BioGPS NCI60207225_atIOSE803.9513.980Details
BioGPS NCI60207225_atJURKAT3.9693.980Details
BioGPS NCI60207225_atK5624.2383.980Details
BioGPS NCI60207225_atKM124.1083.980Details
BioGPS NCI60207225_atLN183.7363.980Details
BioGPS NCI60207225_atLNCAP3.9703.980Details
BioGPS NCI60207225_atLOX IMVI3.9643.980Details
BioGPS NCI60207225_atM143.9293.980Details
BioGPS NCI60207225_atMALME 3M4.2043.980Details
BioGPS NCI60207225_atMCF73.8693.980Details
BioGPS NCI60207225_atMD MB2313.9933.980Details
BioGPS NCI60207225_atMDA MB4354.1673.980Details
BioGPS NCI60207225_atMOLT44.0463.980Details
BioGPS NCI60207225_atNCI 4604.0483.980Details
BioGPS NCI60207225_atNCI H2264.0443.980Details
BioGPS NCI60207225_atNCI H233.9903.980Details
BioGPS NCI60207225_atNCI H322M3.9743.980Details
BioGPS NCI60207225_atNCVADR RES3.8123.980Details
BioGPS NCI60207225_atOVCAR34.1233.980Details
BioGPS NCI60207225_atOVCAR43.9583.980Details
BioGPS NCI60207225_atOVCAR53.9293.980Details
BioGPS NCI60207225_atOVCAR83.7863.980Details
BioGPS NCI60207225_atPANC14.0143.980Details
BioGPS NCI60207225_atRL74.0263.980Details
BioGPS NCI60207225_atRPMI 82264.0143.980Details
BioGPS NCI60207225_atRS118464.1593.980Details
BioGPS NCI60207225_atRXF3933.9563.980Details
BioGPS NCI60207225_atSAOS24.0223.980Details
BioGPS NCI60207225_atSF2683.9713.980Details
BioGPS NCI60207225_atSF2953.9063.980Details
BioGPS NCI60207225_atSF5393.8313.980Details
BioGPS NCI60207225_atSHSYSY+RA3.9173.980Details
BioGPS NCI60207225_atSHSYSY-RA3.9453.980Details
BioGPS NCI60207225_atSKMEL23.9653.980Details
BioGPS NCI60207225_atSKMEL283.9813.980Details
BioGPS NCI60207225_atSKMEL53.8923.980Details
BioGPS NCI60207225_atSKOV34.0853.980Details
BioGPS NCI60207225_atSN12C3.9623.980Details
BioGPS NCI60207225_atSNB193.8443.980Details
BioGPS NCI60207225_atSNB753.9623.980Details
BioGPS NCI60207225_atSR4.0173.980Details
BioGPS NCI60207225_atSW6203.9923.980Details
BioGPS NCI60207225_atT244.0463.980Details
BioGPS NCI60207225_atT3M44.1103.980Details
BioGPS NCI60207225_atTK103.9743.980Details
BioGPS NCI60207225_atU1183.8663.980Details
BioGPS NCI60207225_atU1383.8243.980Details
BioGPS NCI60207225_atU20S3.9023.980Details
BioGPS NCI60207225_atU2513.9383.980Details
BioGPS NCI60207225_atU873.8683.980Details
BioGPS NCI60207225_atUACC2573.9263.980Details
BioGPS NCI60207225_atUACC624.0053.980Details
BioGPS NCI60207225_atUO313.8023.980Details
BioGPS NCI60207225_atZR75_14.0473.980Details
BioGPS NCI60207225_atastrocytes3.9943.980Details
BioGPS NCI60207225_athuh-74.0523.980Details