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Gene ID: 144568 | A2ML1 Antibody Resource


A2ML1 Antibody Resource
Gene Full Name: 
alpha-2-macroglobulin-like 1
Uniprot: 
A8K2U0
Protein Name: 
alpha-2-macroglobulin-like protein 1
Nucleotide: 
NM_144670
Alias: 
CPAMD9;
Ensembl: 
ENSG00000166535
Location: 
12p13.31
HPRD: 
08684
NCBI Gene: 
144568
MIM: 
610627

Summary: 
This gene encodes a member of the alpha-macroglobulin superfamily. The encoded protein acts as an inhibitor for several proteases, and has been reported as the p170 antigen recognized by autoantibodies in the autoimmune disease paraneoplastic pemphigus (PNP; PMID: 20805888). Alternative splicing results in multiple transcript variants. [provided by RefSeq, Feb 2012]
Function: 
Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase . Displays inhibitory activity against chymotrypsin, papain, thermolysin, subtilisin A and, to a lesser extent, elastase but not trypsin. May play an important role during desquamation by inhibiting extracellular proteases. UniProtKB P01023
Subcellular location: 
Secreted .
PTM: 
Disulfide bond;
Disease: 
Biotechnological use: 

Antibodies
TypeCatalogNameClonalitySpecies ReactivityApplicationSizePriceMore Info
Polyclonal Antibody OAAB02144 A2ML1 antibody - N-terminal region (OAAB02144) Human; Mouse WB, ELISA 400ul $289 Details
Polyclonal Antibody ARP59186_P050 A2ML1 Antibody (ARP59186_P050) Polyclonal Human Not tested 50 ug $125 Details
Polyclonal Antibody ARP59187_P050 A2ML1 Antibody (ARP59187_P050) Polyclonal Horse, Human, Pig Not tested 50 ug $125 Details

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Product Images
A2ML1 antibody - N-terminal region (OAAB02144) in Mouse Lung cells using Western Blot

Sample Type: Mouse Lung


A2ML1 Protocols

Publications
Related Gene Trend Categories
Species
CatalogPredicted Species & TargetTarget ReferencePredicted Homology
ARP59186 Chimpanzee A2ML1 antibody; Pan troglodytes A2ML1 antibody H2R2T1 93.0%
ARP59187 Chimpanzee A2ML1 antibody; Pan troglodytes A2ML1 antibody H2R2T1 93.0%
ARP59187 European domestic ferret A2ML1 antibody; Mustela putorius furo A2ML1 antibody M3Z1G3 86.0%
ARP59187 Horse A2ML1 antibody; Equus caballus A2ML1 antibody F6YA47 93.0%
ARP59186 Human A2ML1 antibody; Homo sapiens A2ML1 antibody A8K2U0 100.0%
ARP59187 Human A2ML1 antibody; Homo sapiens A2ML1 antibody A8K2U0 100.0%
ARP59186 Human A2ML1 antibody; Homo sapiens A2ML1 antibody D3DUV3 100.0%
ARP59187 Human A2ML1 antibody; Homo sapiens A2ML1 antibody D3DUV3 100.0%
ARP59187 Human A2ML1 antibody; Homo sapiens A2ML1 antibody F5H2Z2 100.0%
ARP59187 Human A2ML1 antibody; Homo sapiens A2ML1 antibody H0YGG5 100.0%
ARP59187 Pig A2ML1 antibody; Sus scrofa A2ML1 antibody F1SLW8 93.0%
ARP59187 Rhesus macaque A2ML1 antibody; Macaca mulatta A2ML1 antibody H9FHG2 100.0%
ARP59186 Rhesus macaque A2ML1 antibody; Macaca mulatta A2ML1 antibody H9FHX0 93.0%
ARP59186 Small-eared galago A2ML1 antibody; Otolemur garnettii A2ML1 antibody H0X4U9 79.0%
ARP59187 Sumatran orangutan A2ML1 antibody; Pongo abelii A2ML1 antibody H2NGF0 100.0%
ARP59186 Sumatran orangutan A2ML1 antibody; Pongo abelii A2ML1 antibody H2NGF0 93.0%
ARP59187 White-tufted-ear marmoset A2ML1 antibody; Callithrix jacchus A2ML1 antibody F7IAK8 93.0%
ARP59186 White-tufted-ear marmoset A2ML1 antibody; Callithrix jacchus A2ML1 antibody F7ICV0 93.0%
ARP59187 White-tufted-ear marmoset A2ML1 antibody; Callithrix jacchus A2ML1 antibody F7ICV0 93.0%
ARP59186 White-tufted-ear marmoset A2ML1 antibody; Callithrix jacchus A2ML1 antibody F7IFB4 93.0%

Tissue & Cell Line Gene Expression Data