SCYE1 Antibody - N-terminal region (ARP40551_P050)

Catalog No: ARP40551_P050

WB Suggested Anti-SCYE1 Antibody Titration: 0.2-1 ug/ml
Positive Control: Jurkat cell lysateAIMP1 is strongly supported by BioGPS gene expression data to be expressed in Human Jurkat cells

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human SCYE1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 93%; Rabbit: 100%; Rat: 100%; Zebrafish: 86%
• Peptide Sequence: Synthetic peptide located within the following region: LLKEKAILQATLREEKKLRVENAKLKKEIEELKQELIQAEIQNGVKQIPF
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-AIMP1 (ARP40551_P050) antibody is Catalog # AAP40551 (Previous Catalog # AAPP22729)
• Sample Type Confirmation:

  AIMP1 is strongly supported by BioGPS gene expression data to be expressed in Jurkat

• Reference: Tandle,A.T., (2005) Cytokine 30 (6), 347-358

Target Info

• Gene Symbol: AIMP1
• Gene Full Name: Aminoacyl tRNA synthetase complex-interacting multifunctional protein 1
• Alias Symbols: p43, HLD3, EMAP2, SCYE1, EMAPII
• NCBI Gene Id: 9255
• Protein Name: Aminoacyl tRNA synthase complex-interacting multifunctional protein 1
• Description of Target: SCYE1 is a cytokine that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.The protein encoded by this gene is a cytokine that is specifically induced by apoptosis. The release of this cytokine renders the tumor-associated vasculature sensitive to tumor necrosis factor. The precursor of SCYE1 (pro-SCYE1) is identical to the p43 subunit, which is associated with the multi-tRNA synthetase complex. Therefore, pro-SCYE1 may function in binding RNA as part of the tRNA synthetase complex in normal cells and in stimulating inflammatory responses after proteolytic cleavage in tumor cells.
• Uniprot ID: Q12904
• Protein Accession #: NP_004748
• Nucleotide Accession #: NM_004757
• Protein Size (# AA): 312
• Molecular Weight: 34kDa
• Protein Interactions: AIMP2; TSNAX; UBC; CCAR2; RPL36; EEF1E1; IQGAP1; VARS; RPLP0; RPL27A; RPL23A; RPL21; RPL17; RPL15; RPL13; RPL7A; RARS; QARS; PTBP1; PSMC6; MARS; KARS; IARS; DNAJA1; EIF4G1; EIF2S3; EIF2S1; DARS; PAN2; gag; HSP90B1; MAPK8; LARS; EPRS; APP; COPS5; CUL1; PSM