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Now Offering Over 102,157 Antibodies & 44,722 Antigens!

SBDS antibody - N-terminal region (ARP45719_T100)

100 ul
$249.00
In Stock

Conjugation Options

ARP45719_T100-FITC Conjugated

ARP45719_T100-HRP Conjugated

ARP45719_T100-Biotin Conjugated

Gene Symbol:
SBDS
NCBI Gene Id:
51119
Official Gene Full Name:
Shwachman-Bodian-Diamond syndrome
Protein Name:
Ribosome maturation protein SBDS
Swissprot Id:
Q9Y3A5
Protein Accession #:
NP_057122
Nucleotide Accession #:
NM_016038
Alias Symbols:
CGI-97, FLJ10917, SDS, SWDS
Replacement Item:
This antibody may replace item sc-134735 from Santa Cruz Biotechnology.
Description of Target:
SBDS is a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The protein may function in RNA metabolism. Mutations within its gene are associated with Shwachman-Bodian-Diamond syndrome.This gene encodes a member of a highly conserved protein family that exists from archaea to vertebrates and plants. The encoded protein may function in RNA metabolism. Mutations within this gene are associated with Shwachman-Bodian-Diamond syndrome. An alternative transcript has been described, but its biological nature has not been determined. This gene has a closely linked pseudogene that is distally located.
Protein Size (# AA):
250
Molecular Weight:
28kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Protein A purified
Application:
IHC, WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express SBDS.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express SBDS.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human SBDS
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 93%; Rat: 100%; Zebrafish: 85%
Complete computational species homology data:
Anti-SBDS (ARP45719_T100)
Peptide Sequence:
Synthetic peptide located within the following region: LQTHSVFVNVSKGQVAKKEDLISAFGTDDQTEICKQILTKGEVQVSDKER
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
SUMO2; TYMS; PNP; IDH1; GOT1; UBC; CHAMP1; MPLKIP; MRPL53; SARNP; SLIRP; SRPRB; ACOT13; SRRM2; TIMM44; TOMM40; UBE4B; SCO2; SNX3; STX7; SF1; VDAC3; TIAL1; SPR; RBMS1; NDUFA7; NDUFA2; IDH3G; STOM; ACAA1; ACD; TERF2IP; POT1; TERF1; CLN3;
Blocking Peptide:
For anti-SBDS (ARP45719_T100) antibody is Catalog # AAP45719 (Previous Catalog # AAPP11852)
Datasheets/Manuals:
Printable datasheet for anti-SBDS (ARP45719_T100) antibody
Target Reference:
Austin,K.M., (2005) Blood 106 (4), 1253-1258
Publications:

Sezgin, G. et al. Impaired growth, hematopoietic colony formation, and ribosome maturation in human cells depleted of Shwachman-Diamond syndrome protein SBDS. Pediatr. Blood Cancer 60, 281-6 (2013). IHC, WB, Cow, Dog, Guinea Pig, Horse, Human, Mouse, Rabbit, Rat, Zebrafish 22997148

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