Catalog No: OPSN00006
Size:100ug
Price: $370.00
SKU
OPSN00006
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Datasheets/ManualsPrintable datasheet for OPSN00006
Product Info
Predicted Species ReactivitySARS-CoV-2
Product FormatLiquid. 50 mM Tris-HCL, 1M NaCl, pH 7.5
HostSf9 Baculovirus
ConjugationUnconjugated
ApplicationIA, AA, FN
Additional InformationLineage: B.1.351, 20H/501Y.V2
Reconstitution and StorageStore at -20C
Formulation50 mM Tris-HCL, 1M NaCl, pH 7.5
PurificationIMAC
Concentration0.14 mg/mL
Purity90%
TagC-Avitag/His
ReferenceEmergence and rapid spread of a new severe acute respiratory syndrome-related coronavirus 2 (SARS-CoV-2) lineage with multiple spike mutations in South Africa https://doi.org/10.1101/2020.12.21.20248640. Sci Rep. 2021 Apr 28;11(1):9166. doi: 10.1038/s41598-021-88696-5.
DescriptionThe SARS-CoV-2 Spike Receptor Binding Domain E484K, N501Y (South Africa Variant Beta) Recombinant Protein (OPSN00006) is expressed in Sf9 Baculovirus cells and includes a C-terminal Avidin-His Tag with purification via IMAC. The sequence includes amino acids 319-357 of the lineage B.1.351, 20H/501Y.V2 SARS-CoV-2 spike sequence first identified in South Africa. Suitable for Biotinylation and Protein:Protein Interaction assays in a variety of formats.
Gene SymbolS (S1)
Gene Full Namesurface glycoprotein
Alias Symbolsspike glycoprotein
NCBI Gene Id43740568
Protein Namesurface glycoprotein
Description of TargetSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is an enveloped, positive-sense, single-stranded RNA virus that causes coronavirus disease 2019 (COVID-19). Virus particles include the RNA genetic material and structural proteins needed for invasion of host cells. Once inside the cell the infecting RNA is used to encode structural proteins that make up virus particles, nonstructural proteins that direct virus assembly, transcription, replication and host control and accessory proteins whose function has not been determined.~ The structural proteins of SARS-CoV-2 include the envelope protein (E), spike or surface glycoprotein (S), membrane protein (M) and the nucleocapsid protein (N). The spike glycoprotein is found on the outside of the virus particle and gives coronavirus viruses their crown-like appearance. This glycoprotein mediates attachment of the virus particle and entry into the host cell. S protein is an important target for vaccine development, antibody therapies and diagnostic antigen-based tests.
Swissprot IdP0DTC2
Protein Size (# AA)AA 319-537, E484K, N501Y (South Africa Variant Beta)
Molecular Weight30kDa
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express S.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express S.
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