Catalog No: OAAN06661
Price: $0.00
SKU
OAAN06661
Availability: Domestic: within 1-2 weeks delivery | International: 1-2 weeks
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  • $55: Antibody & Protein in US
  • $55 + $25/Kit in US
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Datasheets/ManualsPrintable datasheet for OAAN06661
Product Info
Predicted Species ReactivitySARS-CoV-2
Product FormatLiquid PBS with 0.02% sodium azide,50% glycerol,pH7.3.
ClonalityMonoclonal
IsotypeIgG
HostRabbit
ApplicationELISA, FC, IHC, IF, IP
Reconstitution and StorageStore at 4°C. Avoid freeze / thaw cycles.
ImmunogenRecombinant fusion protein of SARS-CoV-2 Spike 51.
PurificationAffinity purification
Application InfoELISA: 1:1000~5000
FC: 1:50~200
IF: 1:50~200
IP: 1:50~200
Gene SymbolS
Gene Full Namesurface glycoprotein
Alias Symbolsspike glycoprotein
NCBI Gene Id43740568
Protein Namesurface glycoprotein
Description of TargetThe spike (S) glycoprotein of coronaviruses contains protrusions that will only bind to certain receptors on the host cell. Known receptors bind S1 are ACE2, angiotensin-converting enzyme 2; DPP4, dipeptidyl peptidase-4; APN, aminopeptidase N; CEACAM, carcinoembryonic antigen-related cell adhesion molecule 1; Sia, sialic acid; O-ac Sia, O-acetylated sialic acid. The spike is essential for both host specificity and viral infectivity. The term 'peplomer' is typically used to refer to a grouping of heterologous proteins on the virus surface that function together. The spike (S) glycoprotein of coronaviruses is known to be essential in the binding of the virus to the host cell at the advent of the infection process. It's been reported that 2019-nCoV can infect the human respiratory epithelial cells through interaction with the human ACE2 receptor. The spike protein is a large type I transmembrane protein containing two subunits, S1 and S2. S1 mainly contains a receptor binding domain (RBD), which is responsible for recognizing the cell surface receptor. S2 contains basic elements needed for the membrane fusion.The S protein plays key parts in the induction of neutralizing-antibody and T-cell responses, as well as protective immunity. The main functions for the Spike protein are summarized as: Mediate receptor binding and membrane fusion; Defines the range of the hosts and specificity of the virus; Main component to bind with the neutralizing antibody; Key target for vaccine design; Can be transmitted between different hosts through gene recombination or mutation of the receptor binding domain (RBD), leading to a higher mortality rate.
Protein Accession #YP_009724390.1
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express S.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express S.
  1. What is the species homology for "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "SARS-CoV-2".

  2. How long will it take to receive "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: 1-2 weeks".

  3. What buffer format is "SARS-CoV-2 Spike Antibody (OAAN06661)" provided in?

    This item is provided in "Liquid PBS with 0.02% sodium azide,50% glycerol,pH7.3.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    This target may also be called "spike glycoprotein" in publications.

  5. What is the shipping cost for "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "SARS-CoV-2 Spike Antibody (OAAN06661)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "S"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "S"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "S"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "S"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "S"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "S"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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