SARS Antibody - C-terminal region (OAAB04883)

Catalog No: OAAB04883

Size:400UL

Western blot analysis of anti-SARS Antibody (C-term) in NCI-H460 cell lysates (35ug/lane). SARS(arrow) was detected using the purified Pab (1:60dilution).

SARS is strongly supported by BioGPS gene expression data to be expressed in NCI-H460

Formalin-fixed and paraffin-embedded human brain tissue reacted with SARS antibody (C-term), which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Product Info

• Predicted Species Reactivity: Bovine|Hamster|Human|Mouse|Primate|Rabbit|Rat
• Product Format: Purified polyclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.
• Clonality: Polyclonal
• Isotype: Rabbit Ig
• Host: Rabbit
• Application: IHC-P,WB
  Description: This SARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 401~430 amino acids from the C-terminal region of human SARS.
• Reconstitution and Storage: Maintain refrigerated at 2-8C for up to 2 weeks. For long term storage store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: This SARS antibody is generated from rabbits immunized with a KLH conjugated synthetic peptide between 394-422 amino acids from the C-terminal region of human SARS.
• Predicted Homology Based on Immunogen Sequence: Human
• Concentration: Approximately 0.5mg/ml. Actual concentration varies with each lot.
• Sample Type Confirmation:

  SARS is strongly supported by BioGPS gene expression data to be expressed in NCI-H460

• Application Info: WB: 1:1000
  IHC-P: 1:10~50

Target Info

• Gene Symbol: SARS
• Alias Symbols: 62 kDa RNA-binding protein, NEDMAS, S, SARS, Sars1, serine tRNA ligase 1, cytoplasmic, Serine--tRNA ligase, serine--tRNA ligase, cytoplasmic, SERRS, SERS, seryl-aminoacyl-tRNA synthetase, seryl-aminoacyl-tRNA synthetase 1, Seryl-tRNA synthetase, seryl-tRNA synthetase, cytoplasmic, seryl-tRNA(Ser/Sec) synthetase, Strs, transfer RNA-Ser synthetase.
• NCBI Gene Id: 100339002|100689195|101866794|20226|266975|281476|6301
• Protein Name: Serine--tRNA ligase, cytoplasmic|serine--tRNA ligase, cytoplasmic isoform a [Homo sapiens]
• Description of Target: Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser) (PubMed:22353712, PubMed:24095058, PubMed:9431993, PubMed:26433229, PubMed:28236339). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (PubMed:9431993, PubMed:26433229, PubMed:28236339). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC (PubMed:24940000). Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA (PubMed:19423848, PubMed:19423847, PubMed:24940000).|Catalyzes the attachment of serine to tRNA(Ser) in a two-step reaction: serine is first activated by ATP to form Ser-AMP and then transferred to the acceptor end of tRNA(Ser). Is probably also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec). In the nucleus, binds to the VEGFA core promoter and prevents MYC binding and transcriptional activation by MYC. Recruits SIRT2 to the VEGFA promoter, promoting deacetylation of histone H4 at 'Lys-16' (H4K16). Thereby, inhibits the production of VEGFA and sprouting angiogenesis mediated by VEGFA.
• Uniprot ID: P13642|P26636|P26638|P49591|Q4R4U9|Q6P799|Q9GMB8
• Protein Accession #: https://www.ncbi.nlm.nih.gov/protein/NP_006504.2
• Molecular Weight: 58777