SAP18 Protein (OPPA02239)

Catalog No: OPPA02239 (Formerly GWB-EF222E)

Size:5UG

Product Info

• Predicted Species Reactivity: Human
• Product Format: The SAP18 solution contains 20mM Tris-HCl buffer (pH8.0), 0.1M NaCl, 30% glycerol, 1mM DTT. Physical appearance: Sterile Filtered colorless solution.
• Host: E. Coli
  Product Introduction: SAP18 is a component of the histone deacetylase complex which has a significant role in the regulation of eukaryotic gene expression. SAP18 directly interacts with SIN3 and enhances SIN3-mediated transcriptional repression once bound to the promoter. SAP18 plays an important part in gene-specific recruitment of the HDAC complex by a number of transcription factors including Gli, GAGA, and Bicoid. Histone acetylation is significant in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation is catalyzed by multisubunit complexes. SAP18 is a component of the histone deacetylase complex, which includes SIN3, SAP30, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. SAP18 is a component of a splicing-dependent multiprotein EJC (exon junction complex) placed at splice junction on mRNAs.
  Product Description: SAP18 Human Recombinant fused with 20 amino acid His tag at N-terminus produced in E.Coli is a single, non-glycosylated, polypeptide chain containing 173 amino acids (20- 172 a.a.) and having a molecular mass of 19.7 kDa.The SAP18 is purified by proprietary chromatographic techniques.
• Reconstitution and Storage: SAP18 although stable 4C for 4 weeks, should be stored desiccated below -18C. For long term storage it is recommended to add a carrier protein (0. 1% HSA or BSA). Please prevent freeze-thaw cycles.
• Purity: Greater than 90.0% as determined by SDS-PAGE.
• Peptide Sequence: MGSSHHHHHH SSGLVPRGSH MAVESRVTQE EIKKEPEKPI DREKTCPLLL RVFTTNNGRH HRMDEFSRGN VPSSELQIYT WMDATLKELT SLVKEVYPEA RKKGTHFNFA IVFTDVKRPG YRVKEIGSTM SGRKGTDDSM TLQSQKFQIG DYLDIAITPP NRAPPPSGRM RPY.

Target Info

• Gene Symbol: SAP18
• Alias Symbols: SAP18P, 2HOR0202
• NCBI Gene Id: 10284
• Protein Name: Histone deacetylase complex subunit SAP18
• Description of Target: Recombinant Human Sin3A-Associated Protein, 18kDa
• Uniprot ID: O00422
• Protein Accession #: NP_005861.2
• Protein Size (# AA): Recombinant