S1PR4 Antibody - FITC Conjugated (OAEG00108)

Catalog No: OAEG00108

Size:100ug

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid. PBS with 0.08% sodium azide
• Clonality: Monoclonal
• Clone: 1
• Isotype: IgG1
• Host: Mouse
• Conjugation: FITC: Fluorescein Isothiocyanate
• Application: FC, WB
• Reconstitution and Storage: Refrigerate on arrival. Product should be stored at 4-8°C. DO NOT FREEZE. Products are stable for one year from purchase when stored properly.
• Immunogen: Hybridoma produced by the fusion of splenocytes from mice immunized with Unique synthetic peptide derived from the C-terminal of the EDG6 (S1P4) protein and mouse myeloma cells.
• Purification: Protein A/G Chromatography
• Concentration: 1 mg/ml
• Application Info: FC Use 1 ug of antibody per 10⁶ cells. Note: Epitope for the antibody is the C-terminal of the S1PR4 protein. The C-terminal is an intracellular region and cells need to be permeablized prior to staining with antibody. Optimal concentration should be evaluated by serial dilutions.

Target Info

• Gene Symbol: S1PR4
• Gene Full Name: Sphingosine 1 Phosphate 4 Receptor
• Description of Target: EDG6 (S1P4) belongs to a family of G-protein coupled receptors whose ligands are lysophospholipids. The ligand for EDG6 (S1P4) is sphingosine-1-phosphate. There are 8 known members of the EDG receptor family and they are implicated in mediating growth related effects such as induction of cellular proliferation, alterations in differentiation and survival and suppression of apoptosis. They also evoke cellular effector functions that are dependent on cytoskeletal responses such as contraction, secretion, adhesion and chemotaxis. EDG receptors are developmentally regulated and differ in tissue distribution. They couple to multiple types of G proteins to signal through ras and MAP kinase, rho, phospholipase C and several protein tyrosine kinases. EDG6 (S1P4) is expressed in lymphoid and hematopoietic tissue and in the lungs. Recently, the designation of the EDG receptors has been modified to include the ligand for the receptor. Thus, the new designation for the EDG6 (S1P4) receptor is the sphingosine 1-phosphate receptor-4 (S1P4).
• Uniprot ID: O95977