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Catalog No: OACD00279
Price: $0.00
SKU
OACD00279
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Datasheets/ManualsPrintable datasheet for S100A12 Antibody (OACD00279)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.
ClonalityMonoclonal
Clone15#
IsotypeIgG2b Kappa
HostMouse
ApplicationWestern blot
Reconstitution and Storage2°C to 8°C|-20°C
ImmunogenS100A12 Recombinant Protein (OPCD06779)
Recombinant S100A12 (Met1~Glu92) expressed in E. coli
PurificationProtein A/G Purified
Concentration1 mg/ml
Application InfoWestern blotting: 0.5-5 ug/mL: 1:500-2000
Immunocytochemistry: 5-20 ug/mL; 1:50-200
Immunohistochemistry in formalin fixed frozen section: 5-20 ug/mL; 1:50-200
Immunohistochemistry in paraffin section: 5-20 ug/mL; 1:50-200
Optimal working dilutions must be determined by end user.
Gene SymbolS100A12
Gene Full NameS100 calcium binding protein A12
Alias SymbolsCAAF1;CAGC;calcitermin;calcium-binding protein in amniotic fluid 1;calgranulin C;Calgranulin-C;CGRP;ENRAGE;EN-RAGE;extracellular newly identified RAGE-binding protein;migration inhibitory factor-related protein 6;MRP6;MRP-6;neutrophil S100 protein;p6;protein S100-A12;S100 calcium-binding protein A12.
NCBI Gene Id6283
Protein NameProtein S100-A12
Description of TargetS100A12 is a calcium-, zinc- and copper-binding protein which plays a prominent role in the regulation of inflammatory processes and immune response. Its proinflammatory activity involves recruitment of leukocytes, promotion of cytokine and chemokine production, and regulation of leukocyte adhesion and migration. Acts as an alarmin or a danger associated molecular pattern (DAMP) molecule and stimulates innate immune cells via binding to receptor for advanced glycation endproducts (AGER). Binding to AGER activates the MAP-kinase and NF-kappa-B signaling pathways leading to production of proinflammatory cytokines and up-regulation of cell adhesion molecules ICAM1 and VCAM1. Acts as a monocyte and mast cell chemoattractant. Can stimulate mast cell degranulation and activation which generates chemokines, histamine and cytokines inducing further leukocyte recruitment to the sites of inflammation. Can inhibit the activity of matrix metalloproteinases; MMP2, MMP3 and MMP9 by chelating Zn(2+) from their active sites. Possesses filariacidal and filariastatic activity. Calcitermin possesses antifungal activity against C.albicans and is also active against E.coli and P.aeruginosa but not L.monocytogenes and S.aureus.
Uniprot IDP80511
Protein Accession #NP_005612.1
Nucleotide Accession #NM_005621.1
  1. What is the species homology for "S100A12 Antibody (OACD00279)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "S100A12 Antibody (OACD00279)"?

    This item is available "Domestic: within 1-2 weeks delivery | International: within 1-2 weeks delivery".

  3. What buffer format is "S100A12 Antibody (OACD00279)" provided in?

    This item is provided in "Liquid. 0.01M PBS, pH7.4, containing 0.05% Proclin-300, 50% glycerol.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "S100A12 Antibody (OACD00279)"?

    This target may also be called "CAAF1;CAGC;calcitermin;calcium-binding protein in amniotic fluid 1;calgranulin C;Calgranulin-C;CGRP;ENRAGE;EN-RAGE;extracellular newly identified RAGE-binding protein;migration inhibitory factor-related protein 6;MRP6;MRP-6;neutrophil S100 protein;p6;protein S100-A12;S100 calcium-binding protein A12." in publications.

  5. What is the shipping cost for "S100A12 Antibody (OACD00279)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "S100A12 Antibody (OACD00279)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "S100A12 Antibody (OACD00279)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "S100A12 Antibody (OACD00279)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "S100A12"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "S100A12"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "S100A12"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "S100A12"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "S100A12"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "S100A12"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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