RUNX3 Antibody - middle region (OASG06510)

Catalog No: OASG06510

Size:100 uL

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB
• Additional Information: Cellular Localization: Nucleus Cytoplasm. The tyrosine phosphorylated form localizes to the cytoplasm. Translocates from the cytoplasm to the nucleus following TGF-beta stimulation.
  Tissue Specificity: Expressed in gastric cancer tissues (at protein level).
  Sequence & Domain Family: A proline/serine/threonine rich region at the C-terminus is necessary for transcriptional activation of target genes.
• Reconstitution and Storage: Store at -20°C. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from the Internal region of human RUNX3.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phosphorylated on tyrosine residues by SRC. Phosphorylated by LCK and FYN.
• Specificity: RUNX3 Polyclonal Antibody detects endogenous levels of RUNX3 protein.
• Application Info: WB: 1:500~2000
  ELISA: 1:20000

Target Info

• Gene Symbol: RUNX3
• Gene Full Name: runt-related transcription factor 3
• Alias Symbols: AML2, CBFA3, PEBP2aC
• NCBI Gene Id: 864;
• Description of Target: CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, lck, IL-3 and GM-CSF promoters. In association with ZFHX3, upregulates CDKN1A promoter activity following TGF-beta stimulation.
• Uniprot ID: Q13761
• Molecular Weight: 44 kDa