RUNX2 Recombinant Protein (OPCD06760)

Catalog No: OPCD06760

RUNX2 Recombinant Protein (OPCD06760) using SDS-PAGE

RUNX2 Recombinant Protein (OPCD06760) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Ser125-Ala352
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Runx2
• Gene Full Name: runt related transcription factor 2
• Alias Symbols: acute myeloid leukemia 3 protein;AKV core binding factor;AM;AML3;Cbf;Cbfa;Cbfa1;Cbfa-1;CBF-alpha-1;core binding factor alpha 1;Core-binding factor subunit alpha-1;LS3;Oncogene AML-3;Os;Osf2;osteoblast-specific transcription factor 2;PEA2-alpha A;PEB;PEBP2 alpha A;Pebp2a1;PEBP2aA;Pebpa2a;polyomavirus enhancer-binding protein 2 alpha A subunit;runt domain, alpha subunit 1;runt-related transcription factor 2;SL3/AKV core-binding factor alpha A subunit;SL3-3 enhancer factor 1 alpha A subunit;transcription factor Cbfa1/Osf2.
• NCBI Gene Id: 12393
• Protein Name: Runt-related transcription factor 2
• Description of Target: Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation (By similarity). In osteoblasts, supports transcription activation: synergizes with SPEN/MINT to enhance FGFR2-mediated activation of the osteocalcin FGF-responsive element (OCFRE).
• Uniprot ID: Q08775
• Protein Accession #: NP_001139510.1
• Nucleotide Accession #: NM_001146038.2
• Protein Size (# AA): Ser125~Ala352
• Molecular Weight: 28kDa