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Catalog No: ARP38453_P050
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ARP38453_P050
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for anti-RUNX2 (ARP38453_P050) antibody
Product Info
Tested Species ReactivityHuman
Predicted Species ReactivityHuman, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish
Product FormatLiquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
ClonalityPolyclonal
HostRabbit
ApplicationWB
Reconstitution and StorageFor short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
ImmunogenThe immunogen is a synthetic peptide directed towards the C terminal region of human RUNX2
PurificationAffinity Purified
Predicted Homology Based on Immunogen SequenceCow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 100%; Pig: 100%; Rabbit: 83%; Rat: 100%; Zebrafish: 92%
Peptide SequenceSynthetic peptide located within the following region: TTTSNGSTLLNPNLPNQNDGVDADGSHSSSPTVLNSSGRMDESVWRPY
Concentration0.5 mg/ml
Blocking PeptideFor anti-RUNX2 (ARP38453_P050) antibody is Catalog # AAP38453 (Previous Catalog # AAPY01955)
ReferenceRich,J.T., (2008) Biochem. Biophys. Res. Commun. 372 (1), 230-235
Publications

Synergistic effects of overexpression of BMP‑2 and TGF‑b3 on osteogenic differentiation of bone marrow mesenchymal stem cells. Mol Med Rep. 14, 5514-5520 (2016). 27878265

Gene SymbolRUNX2
Gene Full NameRunt-related transcription factor 2
Alias SymbolsCCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1
NCBI Gene Id860
Protein NameRunt-related transcription factor 2
Description of TargetRUNX2 is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis, acting as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants, encoding different protein isoforms, result from alternate promoter use as well as alternate splicing.This gene is a member of the RUNX family of transcription factors and encodes a nuclear protein with an Runt DNA-binding domain. This protein is essential for osteoblastic differentiation and skeletal morphogenesis and acts as a scaffold for nucleic acids and regulatory factors involved in skeletal gene expression. The protein can bind DNA both as a monomer or, with more affinity, as a subunit of a heterodimeric complex. Mutations in this gene have been associated with the bone development disorder cleidocranial dysplasia (CCD). Transcript variants that encode different protein isoforms result from the use of alternate promoters as well as alternate splicing.
Uniprot IDQ13950-2
Protein Accession #NP_004339
Nucleotide Accession #NM_004348
Protein Size (# AA)507
Molecular Weight55kDa
Protein InteractionsHDAC7; HDAC6; TP53; UBC; RB1; PML; HIF1A; SMURF1; SMAD1; SMURF2; HIVEP3; WWP1; FHL2; UBTF; SUV39H1; HDAC1; STAT3; SMAD3; RBM14; SOX9; NR0B2; EP300; HDAC5; HDAC4; HDAC3; CREBBP; XRCC5; HES1; XRCC6; BMPR1A; KAT2B; TLE1; YAP1; KAT6B; TAF1A; AXIN1; SMAD6; MAP
  1. What is the species homology for "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Zebrafish".

  2. How long will it take to receive "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "RUNX2 Antibody - C-terminal region (ARP38453_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    This target may also be called "CCD, AML3, CCD1, CLCD, OSF2, CBFA1, OSF-2, PEA2aA, PEBP2aA, CBF-alpha-1" in publications.

  5. What is the shipping cost for "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "55kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "RUNX2 Antibody - C-terminal region (ARP38453_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RUNX2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RUNX2"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RUNX2"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RUNX2"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RUNX2"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RUNX2"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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