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RUNX1T1 Antibody (OADC00048)

Catalog#: OADC00048
Domestic: within 1 week delivery | International: 1 week
More Information
Predicted Species ReactivityHuman
Product FormatLiquid. Whole antiserum from rabbit containing 0.05% azide.
Reconstitution and StorageStore at -20C. Avoid repeated freeze/thaw cycles.
Replacement ItemThis antibody may replace item sc-134335 from Santa Cruz Biotechnology.
PurificationWhole antiserum
ConcentrationUndetermined, ascites
Datasheets/ManualsPrintable datasheet for anti-RUNX1T1 (OADC00048) antibody
Preservative0.05% Sodium Azide
SpecificityPolyclonal antibody raised in rabbit against human ETO (runt-related transcription factor 1; translocated to, 1 (cyclin D-related)) using two KLH-conjugated synthetic peptides containing sequences from the N-terminal and the central region of the protein, respectively.
Application InfoCHIP: 4 ul/CHIP
ELISA: 1:100
Gene SymbolRUNX1T1
Official Gene Full NameRUNX1 translocation partner 1
Alias SymbolsCDR, ETO, MTG8, AML1T1, ZMYND2, CBFA2T1, AML1-MTG8
NCBI Gene Id862;
Protein Nameprotein CBFA2T1
Description of TargetThis gene encodes a member of the myeloid translocation gene family which interact with DNA-bound transcription factors and recruit a range of corepressors to facilitate transcriptional repression. The t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities in acute myeloid leukemia. The translocation produces a chimeric gene made up of the 5'-region of the runt-related transcription factor 1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Alternative splicing results in multiple transcript variants.
Swissprot IdQ06455
Protein Accession #NP_001185554.1
Nucleotide Accession #NM_001198625.1
Tissue ToolFind tissues and cell lines supported by DNA array analysis to express RUNX1T1.
RNA SeqFind tissues and cell lines supported by RNA-seq analysis to express RUNX1T1.
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