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RUNX1T1 antibody - middle region (ARP58127_P050)

100 ul
$319.00
In Stock

Conjugation Options

ARP58127_P050-FITC Conjugated

ARP58127_P050-HRP Conjugated

ARP58127_P050-Biotin Conjugated

Gene Symbol:
RUNX1T1
NCBI Gene Id:
862
Official Gene Full Name:
Runt-related transcription factor 1; translocated to, 1 (cyclin D-related)
Protein Name:
cDNA, FLJ92968, highly similar to Homo sapiens runt-related transcription factor 1; translocated to, 1 (cyclin D-related) (RUNX1T1), transcript variant 1, mRNA EMBL BAG35486.1
Swissprot Id:
B2R6I9
Protein Accession #:
NP_004340
Nucleotide Accession #:
NM_004349
Alias Symbols:
AML1T1, CBFA2T1, CDR, ETO, MGC2796, MTG8, MTG8b, ZMYND2
Replacement Item:
This antibody may replace item sc-134335 from Santa Cruz Biotechnology.
Description of Target:
RUNX1T1 is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. The protein encoded by this gene is a putative zinc finger transcription factor and oncoprotein. In acute myeloid leukemia, especially in the M2 subtype, the t(8;21)(q22;q22) translocation is one of the most frequent karyotypic abnormalities. The translocation produces a chimeric gene made up of the 5'-region of the RUNX1 gene fused to the 3'-region of this gene. The chimeric protein is thought to associate with the nuclear corepressor/histone deacetylase complex to block hematopoietic differentiation. Several transcript variants encoding multiple isoforms have been found for this gene.
Protein Size (# AA):
577
Molecular Weight:
64kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB, IHC
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RUNX1T1.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RUNX1T1.
Immunogen:
The immunogen is a synthetic peptide directed towards the middle region of human RUNX1T1
Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Mouse, Pig, Rabbit, Rat, Zebrafish
Predicted Homology Based on Immunogen Sequence:
Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 93%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 86%; Zebrafish: 93%
Complete computational species homology data:
Anti-RUNX1T1 (ARP58127_P050)
Peptide Sequence:
Synthetic peptide located within the following region: RQCNLQQFIQQTGAALPPPPRPDRGPPGTQGPLPPAREESLLGAPSESHA
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
EPS8; NECAB2; ABI3; GSE1; MID2; SPRY2; HOMER3; LPXN; ZMYM4; STX11; MEOX2; CCDC36; TRIM42; SPERT; CREB3L1; LZTS2; EFHC2; CPSF7; C19orf57; PRDM14; CBFA2T2; NCOR1; UBQLN4; ATN1; BCL6; ETS1; RUNX1; DNMT1; SPEN; RBPJ; UBE2E2; UBC; TRIM33; HDAC1; NCOR2; SIN3A;
Blocking Peptide:
For anti-RUNX1T1 (ARP58127_P050) antibody is Catalog # AAP58127 (Previous Catalog # AAPP32560)
Datasheets/Manuals:
Printable datasheet for anti-RUNX1T1 (ARP58127_P050) antibody
Target Reference:
Salat,D., (2008) Mol. Cell. Biol. 28 (10), 3502-3512

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