RTN3 Antibody - C-terminal region (OABB01421)

Catalog No: OABB01421

Size:100ug

Anti-RTN3 antibody, OABB01421, Western blotting
All lanes: Anti RTN3 (OABB01421) at 0.5ug/ml
Lane 1: Rat Brain Tissue Lysate at 50ug
Lane 2: Mouse Brain Tissue Lysate at 50ug
Lane 3: U87 Whole Cell Lysate at 40ug
Predicted bind size: 116 kDa
Observed bind size: 150 kDa

Anti-RTN3 antibody, OABB01421, IHC(P)
IHC(P): Human Mammary Cancer Tissue

Anti-RTN3 antibody, OABB01421, IHC(P)
IHC(P): Rat Brain Tissue

Product Info

• Tested Species Reactivity: Human, Mouse, Rat
• Product Format: Lyophilized 5 mg BSA, 0.9 mg NaCl, 0.2 mg Na₂HPO₄, 0.05 mg Thimerosal, 0.05 mg sodium azide
• Clonality: Polyclonal
• Clone: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC-P
• Reconstitution and Storage: Adding 0.2 ml of distilled water will yield a concentration of 500 ug/ml. At -20°C for one year from date of receipt. After reconstitution, at 4°C for one month. It can also be aliquotted and stored frozen at -20°C for six months. Avoid repeated freezing and thawing.
• Immunogen: A synthetic peptide corresponding to a sequence at the C-terminus of human RTN3(1017-1032aa EKIQAKLPGIAKKKAE), identical to the related mouse and rat sequences.
• Purification: Immunogen affinity purified.
• Specificity: No cross reactivity with other proteins.
• Application Info: WB: 0.1-0.5 ug/ml. Tested Species: Hu, Ms, Rat
  IHC-P: 0.5-1 ug/mL. Tested Species: Hu, Rat. Predicted Species: Ms. Antigen retrieval is by heat, where boiling the paraffin sections in 10mM citrate buffer (pH 6.0) for 20 mins is required for the staining of formalin/paraffin sections.
• Publications:

  Infants Uniquely Express High Levels of RBM3 and Other Cold-Adaptive Neuroprotectant Proteins in the Human Brain. Dev Neurosci. 40, 325-336 (2018). 30399610

• Description:
  View product citations for RTN3 Antibody - C-terminal region (OABB01421) on CiteAb

Target Info

• Gene Symbol: RTN3
• Gene Full Name: reticulon 3
• Alias Symbols: ASYIP, Neuroendocrine specific protein like 2, Neuroendocrine-specific protein-like 2, Neuroendocrine-specific protein-like II, NSP like protein II, NSP-like protein 2, NSP-like protein II, NSPL2, NSPLII, Reticulon 3, Reticulon-3, Reticulon3, Rtn3, RTN3_HUMAN
• Protein Name: Reticulon-3
• Description of Target: Reticulon-3, also known as RTN3 or NSPL2, is a protein that in humans is encoded by the RTN3 gene. It is mapped to 11q13, which is between markers D11S4535 and D11S4627. This gene belongs to the reticulon family of highly conserved genes that are preferentially expressed in neuroendocrine tissues. This family of proteins interact with, and modulate the activity of beta-amyloid converting enzyme 1(BACE1), and the production of amyloid-beta. RTN3 colocalized with BACE1 in neurons of human brain gray matter, and overexpression of RTN3 in vitro inhibited BACE1 activity and decreased amyloid precursor protein processing. 
• Uniprot ID: O95197
• Molecular Weight: 113 kDa