RSPO1 Antibody (OAEC04480)

Catalog No: OAEC04480

Size:100 ug/100 ul

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Western blot analysis using R-spondin1 mouse mAb against recombinant R-spondin1 protein (1) and R-spondin1 (aa21-263)-hIgGFc transfected HEK293 cell lysate (2).

Product Info

• Predicted Species Reactivity: Human
• Product Format: Ascitic fluid containing 0.03% sodium azide
• Clonality: Monoclonal
• Clone: 7A6
• Isotype: IgG1
• Host: Mouse
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Purified recombinant fragment of R-spondin1 expressed in EColi.
• Concentration: 1 mg/ml
• Application Info: WB: 1/500 - 1/2000
  ELISA: 1/10000
  

Target Info

• Gene Symbol: RSPO1
• Gene Full Name: R-spondin 1
• Alias Symbols: RSPO, CRISTIN3
• NCBI Gene Id: 284654
• Description of Target: R-spondin1, also known as RSPO1, CRISTIN3, FLJ40906. Entrez Protein NP_001033722.1.It is a member of the R-spondin family and a 28.9kDa secreted activator protein with two cys tein-rich, furin-like domains and one thrombospondin type 1 domain. In mice, the protein induces the rapid onset of crypt cell proliferation and increases intestinal epithelial healing, providing a protective effect against chemotherapy-induced adverse effects .It is activator of the beta-catenin signaling cascade, leading to TCF-dependent gene activation. Acts both in the canonical Wnt/beta-catenin-dependent pathway, possibly via a direct interaction with Wnt proteins, and in a Wnt-independent beta catenin pathway through a receptor signaling pathway that may not use frizzled/LRP receptors. Acts as a ligand for frizzled FZD8 and LRP6. May negatively regulate the TGF-beta pathway. Has a essential roles in ovary determination.
• Uniprot ID: Q2MKA7
• Molecular Weight: 28.9 kDa