RSAD2 Antibody (OACA07828)

Catalog No: OACA07828

Immunohistochemistry of paraffin-embedded human kidney at dilution 1:100

Immunohistochemistry of paraffin-embedded human skin at dilution 1:100

Immunohistochemistry of paraffin-embedded human kidney at dilution 1:100

Immunohistochemistry of paraffin-embedded human skin at dilution 1:100

Product Info

• Predicted Species Reactivity: Human
• Product Format: Liquid
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Conjugation: Unconjugated
• Application: Enzyme-linked immunosorbent assay|Immunohistochemistry
• Reconstitution and Storage: -20°C or -80°C
• Immunogen: Recombinant Human Radical S-adenosyl methionine domain-containing protein 2 protein (42-361AA)
• Purification: Affinity Purified
• Preservative: 0.02% sodium azide
• Formulation: PBS with, 50% glycerol, pH7.3.
• Reference: [1]"Viperin (cig5), an IFN-inducible antiviral protein directly induced by human cytomegalovirus." Chin K.-C., Cresswell P.Proc. Natl. Acad. Sci. U.S.A. 98:15125-15130(2001). [2]"Generation and annotation of the DNA sequences of human chromosomes 2 and 4."Hillier L.W., Graves T.A., Fulton R.S., Fulton L.A., Pepin K.H., Minx P., Wagner-McPherson C., Layman D., Wylie K., Sekhon M., Becker M.C., Fewell G.A., Delehaunty K.D., Miner T.L., Nash W.E., Kremitzki C., Oddy L., Du H. Wilson R.K.Nature 434:724-731(2005). [3]"The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC)."The MGC Project TeamGenome Res. 14:2121-2127(2004).

Target Info

• Gene Symbol: RSAD2
• Gene Full Name: radical S-adenosyl methionine domain containing 2
• Alias Symbols: cig33;cig5;cytomegalovirus-induced gene 5 protein;radical S-adenosyl methionine domain-containing protein 2;vig1;viperin;virus inhibitory protein, endoplasmic reticulum-associated, interferon-inducible.
• NCBI Gene Id: 91543
• Protein Name: Radical S-adenosyl methionine domain-containing protein 2
• Description of Target: Interferon-inducible iron-sulfur (4FE-4S) cluster-binding antiviral protein which plays a major role in the cell antiviral state induced by type I and type II interferon. Can inhibit a wide range of DNA and RNA viruses, including human cytomegalovirus (HCMV), hepatitis C virus (HCV), west Nile virus (WNV), dengue virus, sindbis virus, influenza A virus, sendai virus, vesicular stomatitis virus (VSV), and human immunodeficiency virus (HIV-1). Displays antiviral activity against influenza A virus by inhibiting the budding of the virus from the plasma membrane by disturbing the lipid rafts. This is accomplished, at least in part, through binding and inhibition of the enzyme farnesyl diphosphate synthase (FPPS), which is essential for the biosynthesis of isoprenoid-derived lipids. Promotes TLR7 and TLR9-dependent production of IFN-beta production in plasmacytoid dendritic cells (pDCs) by facilitating Lys-63'-linked ubiquitination of IRAK1. Plays a role in CD4+ T-cells activation and differentiation. Facilitates T-cell receptor (TCR)-mediated GATA3 activation and optimal T-helper 2 (Th2) cytokine production by modulating NFKB1 and JUNB activities. Can inhibit secretion of soluble proteins.
• Uniprot ID: Q8WXG1
• Protein Accession #: NP_542388
• Nucleotide Accession #: NM_080657