RRM1 Antibody - N-terminal region (ARP46030_T100)

Catalog No: ARP46030_T100

WB Suggested Anti-RRM1 Antibody Titration: 1.25ug/ml
Positive Control: HepG2 cell lysate

Product Info

• Tested Species Reactivity: Human
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Rabbit, Yeast, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RRM1
• Purification: Protein A purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 100%; Horse: 100%; Human: 100%; Mouse: 100%; Rabbit: 100%; Rat: 100%; Yeast: 100%; Zebrafish: 100%
• Peptide Sequence: Synthetic peptide located within the following region: ATGSYIAGTNGNSNGLVPMLRVYNNTARYVDQGGNKRPGAFAIYLEPWHL
• Concentration: 1.0 mg/ml
• Blocking Peptide: For anti-RRM1 (ARP46030_T100) antibody is Catalog # AAP46030 (Previous Catalog # AAPP26873)
• Reference: Bryan,B.A., J. Gen. Virol. 87 (PT 3), 519-529 (2006)

Target Info

• Gene Symbol: RRM1
• Gene Full Name: Ribonucleotide reductase M1
• Alias Symbols: R1, RR1, RIR1
• NCBI Gene Id: 6240
• Protein Name: Ribonucleoside-diphosphate reductase large subunit
• Description of Target: RRM1 is one of two non-identical subunits that constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. Its gene is located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. Its gene may play a role in malignancies and disease that involve this region.Western blots using two different antibodies against two unique regions of this protein target confirm the same apparent molecular weight in our tests.This gene encodes one of two non-identical subunits which constitute ribonucleoside-diphosphate reductase, an enzyme essential for the production of deoxyribonucleotides prior to DNA synthesis in S phase of dividing cells. It is one of several genes located in the imprinted gene domain of 11p15.5, an important tumor-suppressor gene region. Alterations in this region have been associated with the Beckwith-Wiedemann syndrome, Wilms tumor, rhabdomyosarcoma, adrenocrotical carcinoma, and lung, ovarian, and breast cancer. This gene may play a role in malignancies and disease that involve this region. This gene is oriented in a head-to-tail configuration with the stromal interaction molecule 1 gene (STIM1), with the 3' end of STIM1 situated 1.6 kb from the 5' end of this gene.
• Uniprot ID: P23921
• Protein Accession #: NP_001024
• Nucleotide Accession #: NM_001033
• Protein Size (# AA): 792
• Molecular Weight: 90kDa
• Protein Interactions: UBC; RRM1; SUMO2; RNF2; BMI1; PPIB; TNPO1; FBXO6; PPP1CC; TMEM177; DNAJB11; SUCLA2; SGSH; NDUFV1; EEF2; DNASE2; COPS5; CDK2; RRM2; RRM2B; KAT5; LRIF1; YWHAG;