RPN1 Antibody - N-terminal region (ARP40436_P050)

Catalog No: ARP40436_P050

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WB Suggested Anti-RPN1 Antibody
Titration: 1 ug/ml
Positive Control: HeLa and CHO-K1 cell lines, rouch canine microsomes

Product Info

• Tested Species Reactivity: Dog
• Predicted Species Reactivity: Human, Mouse, Rat, Cow, Dog, Guinea Pig, Horse, Pig, Rabbit, Yeast, Zebrafish
• Product Format: Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
• Clonality: Polyclonal
• Host: Rabbit
• Application: WB
• Reconstitution and Storage: For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
• Immunogen: The immunogen is a synthetic peptide directed towards the N terminal region of human RPN1
• Purification: Affinity Purified
• Predicted Homology Based on Immunogen Sequence: Cow: 100%; Dog: 100%; Guinea Pig: 93%; Horse: 100%; Human: 100%; Mouse: 93%; Pig: 100%; Rabbit: 100%; Rat: 93%; Yeast: 100%; Zebrafish: 80%
• Peptide Sequence: Synthetic peptide located within the following region: TSRATSFLLALEPELEARLAHLGVQVKGEDEEENNLEVRETKIKGKSGRF
• Concentration: 0.5 mg/ml
• Blocking Peptide: For anti-RPN1 (ARP40436_P050) antibody is Catalog # AAP40436 (Previous Catalog # AAPS03011)
• Subunit: 1
• Reference: Ewing,R.M., Mol. Syst. Biol. 3, 89 (2007)

Target Info

• Gene Symbol: RPN1
• Gene Full Name: Ribophorin I
• Alias Symbols: OST1, RBPH1
• NCBI Gene Id: 6184
• Protein Name: Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit 1
• Description of Target: RPN1 is a type I integral membrane protein found only in the rough endoplasmic reticulum. It is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. RPN1 forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. This gene encodes a type I integral membrane protein found only in the rough endoplasmic reticulum. The encoded protein is part of an N-oligosaccharyl transferase complex that links high mannose oligosaccharides to asparagine residues found in the Asn-X-Ser/Thr consensus motif of nascent polypeptide chains. This protein forms part of the regulatory subunit of the 26S proteasome and may mediate binding of ubiquitin-like domains to this proteasome. Publication Note: This RefSeq record includes a subset of the publications that are available for this gene. Please see the Entrez Gene record to access additional publications.
• Uniprot ID: P04843
• Protein Accession #: NP_002941
• Nucleotide Accession #: NM_002950
• Protein Size (# AA): 607
• Molecular Weight: 69kDa
• Protein Interactions: UBQLN1; UBC; SGTA; SUMO3; STAU1; LGR4; SUMO1; NEDD8; MDM2; ASB5; ASB11; BMI1; EED; RNF2; EGFR; ADRB2; CLN5; CLN3; AMFR; OST4; MMS19; env; UBL4A; WHSC1; VCAM1; FN1; ATF2; VCP; ESR1; ECT2; STT3B; SND1; SYNCRIP; TECR; VDAC2; SSR3; RPN2; RPSA; ILF3; SLC25A5;