ROR1 Antibody (OAAD00316)

Catalog No: OAAD00316

Size:0.1ml

western blot analysis using ROR1 mouse mAb against extracellular domain of human ROR1 (aa30-423).

Confocal immunofluorescence analysis of HEK293 cells trasfected with extracellular ROR1 (aa30-406)-hIgGFc using ROR1 mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye.

Product Info

• Predicted Species Reactivity: Human
• Clonality: Monoclonal
• Clone: 2H6
• Isotype: IgG1
• Host: Mouse
• Application: WB, IF
• Reconstitution and Storage: Store at 4C, for long term storage, store at -20C.
• Immunogen: Recombinant extracellular fragment of human ROR1 (aa30-406) fused with hIgGFc tag, expressed in HEK293 cells
• Formulation: Ascitic fluid containing 0.03% sodium azide.
• Application Info: Western Bloting: 1/500 - 1/2000.
  Immunofluorescence: 1/200 - 1/1000.
  ELISA: Propose dilution 1/10000.
  Not yet tested in other applications.
  Determining optimal working dilutions by titration test.
• Reference: 1. J Cell Sci. 2005 Jan 15;118(Pt 2):433-46.
  2. Oncogene. 1996 Oct 3;13(7):1555-9.

Target Info

• Alias Symbols: NTRKR1, dJ537F10.1
• NCBI Gene Id: 4919
• Description of Target: ROR1, a type I membrane protein, is a receptor protein tyrosine kinase that modulates neurite growth in the central nervous system. The ROR-family receptor tyrosine kinases consist of two structurally related proteins, ROR1 and ROR2. These proteins are characterized by having intracellular tyrosine kinase domains, which are highly related to Trk-family kinases, extracellular Frizzled-like cysteine-rich domains (CRDs) and Kringle domains. The ROR family members are highly conserved among species, such as C. elegans, Drosophila, Xenopus and mammals. ROR1 and ROR2 are both involved in organogenesis with particular emphasis in neuronal differentiation. Increased expression of ROR1 in acute lymphoblastic leukemias (ALLs) as well as chronic lymphocytic leukemias (CLLs) implicate this protein as a potential tool for targeted immunotherapy in these diseases.
• Uniprot ID: Q01973
• Molecular Weight: 101kDa