ROCK1 Recombinant Protein (OPCD06734)

Catalog No: OPCD06734

ROCK1 Recombinant Protein (OPCD06734) using SDS-PAGE

ROCK1 Recombinant Protein (OPCD06734) using SDS-PAGE

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Freeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
• Host: E.coli
• Conjugation: Unconjugated
• Application: Positive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
• Additional Information: Endotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
  Residues: Leu1094-Gly1323
  Subcellular Location: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Golgi apparatus membrane; Peripheral membrane protein. Cell projection, bleb. Cell membra
• Reconstitution and Storage: 2°C to 8°C|-80°C
• Concentration: 200 ug/mL (prior to lyoph)
• Purity: > 95%
• Source: E.coli
• Tag: N-terminal His Tag

Target Info

• Gene Symbol: Rock1
• Gene Full Name: Rho-associated coiled-coil containing protein kinase 1
• Alias Symbols: 1110055K06Rik;p160 ROCK-1;p160ROCK;Rho-associated coiled-coil forming kinase 1;rho-associated protein kinase 1;rho-associated, coiled-coil-containing protein kinase 1;rho-associated, coiled-coil-containing protein kinase I;Roc;Rock-I.
• NCBI Gene Id: 19877
• Protein Name: Rho-associated protein kinase 1
• Description of Target: Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. Involved in regulation of smooth muscle contraction, actin cytoskeleton organization, stress fiber and focal adhesion formation, neurite retraction, cell adhesion and motility via phosphorylation of DAPK3, GFAP, LIMK1, LIMK2, MYL9/MLC2, PFN1 and PPP1R12A. Phosphorylates FHOD1 and acts synergistically with it to promote SRC-dependent non-apoptotic plasma membrane blebbing. Required for centrosome positioning and centrosome-dependent exit from mitosis. Plays a role in terminal erythroid differentiation. Promotes keratinocyte terminal differentiation (By similarity). Phosphorylates JIP3 and regulates the recruitment of JNK to JIP3 upon UVB-induced stress. Acts as a suppressor of inflammatory cell migration by regulating PTEN phosphorylation and stability. Acts as a negative regulator of VEGF-induced angiogenic endothelial cell activation. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. May regulate closure of the eyelids and ventral body wall by inducing the assembly of actomyosin bundles.
• Uniprot ID: P70335
• Protein Accession #: NP_033097.1
• Nucleotide Accession #: NM_009071.2
• Protein Size (# AA): Leu1094~Gly1323
• Molecular Weight: 33kDa