Size:100 ul
Special Price $229.00 Regular Price $289.00
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ARP74184_P050
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Conjugation Options

ARP74184_P050-FITC Conjugated

ARP74184_P050-HRP Conjugated

ARP74184_P050-Biotin Conjugated

ROBO3 Antibody - C-terminal region (ARP74184_P050)

Catalog#: ARP74184_P050
Domestic: within 1-2 days delivery | International: 1-2 days
More Information
Tested Species Reactivity Human
Predicted Species Reactivity Human
Product Format Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality Polyclonal
Host Rabbit
Application WB
Reconstitution and Storage For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Replacement Item This antibody may replace item sc-44498 from Santa Cruz Biotechnology.
Immunogen The immunogen is a synthetic peptide directed towards the C-terminal region of Human ROBO3
Purification Affinity Purified
Peptide Sequence Synthetic peptide located within the following region: HPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGP
Concentration Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Blocking Peptide For anti-ROBO3 (ARP74184_P050) antibody is Catalog # AAP74184
Datasheets/Manuals Printable datasheet for anti-ROBO3 (ARP74184_P050) antibody
Gene Symbol ROBO3
Alias Symbols ROBO3,
NCBI Gene Id 64221
Description of Target This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Swissprot Id Q96MS0
Protein Accession # NP_071765
Protein Size (# AA) 1386
Molecular Weight 152kDa
Tissue Tool Find tissues and cell lines supported by DNA array analysis to express ROBO3.
RNA Seq Find tissues and cell lines supported by RNA-seq analysis to express ROBO3.
Protein Interactions CCDC57; LNX1; RBMX; MTUS2; Zswim8; APOA1; NEDD4L; UBC;
  1. What is the species homology for "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    The tested species reactivity for this item is "Human". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    This item is available "Domestic: within 1-2 days delivery | International: 1-2 days".

  3. What buffer format is "ROBO3 Antibody - C-terminal region (ARP74184_P050)" provided in?

    This item is provided in "Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    This target may also be called "ROBO3, " in publications.

  5. What is the shipping cost for "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "152kDa".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "ROBO3 Antibody - C-terminal region (ARP74184_P050)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data tab on the product page.

  10. What are positive controls for "ROBO3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "ROBO3"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "ROBO3"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "ROBO3"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "ROBO3"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "ROBO3"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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