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ROBO3 Antibody - C-terminal region (ARP74184_P050)

100 ul

Regular Price: $289.00

Special Price: $229.00

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Conjugation Options

ARP74184_P050-FITC Conjugated

ARP74184_P050-HRP Conjugated

ARP74184_P050-Biotin Conjugated

Tested Species Reactivity:
Human
Predicted Species Reactivity:
Human
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Gene Symbol:
ROBO3
NCBI Gene Id:
64221
Swissprot Id:
Q96MS0
Protein Accession #:
NP_071765
Alias Symbols:
ROBO3,
Replacement Item:
This antibody may replace item sc-44498 from Santa Cruz Biotechnology.
Description of Target:
This gene is a member of the Roundabout (ROBO) gene family that controls neurite outgrowth, growth cone guidance, and axon fasciculation. ROBO proteins are a subfamily of the immunoglobulin transmembrane receptor superfamily. SLIT proteins 1-3, a family of secreted chemorepellants, are ligands for ROBO proteins and SLIT/ROBO interactions regulate myogenesis, leukocyte migration, kidney morphogenesis, angiogenesis, and vasculogenesis in addition to neurogenesis. This gene, ROBO3, has a putative extracellular domain with five immunoglobulin (Ig)-like loops and three fibronectin (Fn) type III motifs, a transmembrane segment, and a cytoplasmic tail with three conserved signaling motifs: CC0, CC2, and CC3 (CC for conserved cytoplasmic). Unlike other ROBO family members, ROBO3 lacks motif CC1. The ROBO3 gene regulates axonal navigation at the ventral midline of the neural tube. In mouse, loss of Robo3 results in a complete failure of commissural axons to cross the midline throughout the spinal cord and the hindbrain. Mutations ROBO3 result in horizontal gaze palsy with progressive scoliosis (HGPPS); an autosomal recessive disorder characterized by congenital absence of horizontal gaze, progressive scoliosis, and failure of the corticospinal and somatosensory axon tracts to cross the midline in the medulla. Alternative transcript variants have been described but have not been experimentally validated.
Protein Size (# AA):
1386
Molecular Weight:
152kDa
Purification:
Affinity Purified
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express ROBO3.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express ROBO3.
Immunogen:
The immunogen is a synthetic peptide directed towards the C-terminal region of Human ROBO3
Peptide Sequence:
Synthetic peptide located within the following region: HPSRSPSAQEPRGSCCPSNPDPDDRYYNEAGISLYLAQTARGTAAPGEGP
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
CCDC57; LNX1; RBMX; MTUS2; Zswim8; APOA1; NEDD4L; UBC;
Blocking Peptide:
For anti-ROBO3 (ARP74184_P050) antibody is Catalog # AAP74184
Datasheets/Manuals:
Printable datasheet for anti-ROBO3 (ARP74184_P050) antibody

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