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RNF6 Antibody - N-terminal region (ARP43064_P050)

100 ul
$289.00
In Stock
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Conjugation Options

ARP43064_P050-FITC Conjugated

ARP43064_P050-HRP Conjugated

ARP43064_P050-Biotin Conjugated

Gene Symbol:
RNF6
Official Gene Full Name:
Ring finger protein (C3H2C3 type) 6
NCBI Gene Id:
6049
Protein Name:
E3 ubiquitin-protein ligase RNF6
Swissprot Id:
Q9Y252
Protein Accession #:
NP_005968
Nucleotide Accession #:
NM_005977
Alias Symbols:
DKFZp686P0776
Replacement Item:
This antibody may replace item sc-106519 from Santa Cruz Biotechnology.
Description of Target:
RNF6 contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. The protein encoded by this gene contains a RING-H2 finger motif. Deletions and mutations in this gene were detected in esophageal squamous cell carcinoma (ESCC), suggesting that this protein may be a potential tumor suppressor. Studies of the mouse counterpart suggested a role of this protein in the transcription regulation that controls germinal differentiation. Multiple alternatively spliced transcript variants encoding the same protein are observed.
Protein Size (# AA):
685
Molecular Weight:
78kDa
Host:
Rabbit
Clonality:
Polyclonal
Purification:
Affinity Purified
Application:
WB
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RNF6.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RNF6.
Immunogen:
The immunogen is a synthetic peptide directed towards the N terminal region of human RNF6
Predicted Species Reactivity:
Cow, Dog, Guinea Pig, Horse, Human, Pig, Rabbit, Rat
Tested Species Reactivity:
Human
Predicted Homology Based on Immunogen Sequence:
Cow: 85%; Dog: 86%; Guinea Pig: 85%; Horse: 86%; Human: 100%; Pig: 86%; Rabbit: 85%; Rat: 86%
Complete computational species homology data:
Anti-RNF6 (ARP43064_P050)
Peptide Sequence:
Synthetic peptide located within the following region: LQQRLDGVKEQLASQPDLRDGTNYRDSEVPRESSHEDSLLEWLNTFRRTG
Product Format:
Liquid. Purified antibody supplied in 1x PBS buffer with 0.09% (w/v) sodium azide and 2% sucrose.
Reconstitution and Storage:
For short term use, store at 2-8C up to 1 week. For long term storage, store at -20C in small aliquots to prevent freeze-thaw cycles.
Concentration:
Batch dependent within range: 100 ul at 0.5 - 1 mg/ml
Protein Interactions:
UBE2D1; AR; LDB1; UBC; tat; UBE2H;
Blocking Peptide:
For anti-RNF6 (ARP43064_P050) antibody is Catalog # AAP43064 (Previous Catalog # AAPP25040)
Datasheets/Manuals:
Printable datasheet for anti-RNF6 (ARP43064_P050) antibody
Target Reference:
Tursun,B., (2005) Genes Dev. 19 (19), 2307-2319

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