Catalog No: OACA05890
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OACA05890
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  • $55: Antibody & Protein in US
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Datasheets/ManualsPrintable datasheet for RNF31 Antibody (OACA05890) (OACA05890)
Product Info
Predicted Species ReactivityHuman
Product FormatLiquid
ClonalityPolyclonal
IsotypeIgG
HostRabbit
ConjugationUnconjugated
ApplicationEnzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry
Reconstitution and Storage-20°C or -80°C
ImmunogenRecombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA)
PurificationProtein G Purified
Preservative0.03% Proclin 300
Formulation50% Glycerol, 0.01M PBS, PH 7.4
Gene SymbolRNF31
Gene Full Namering finger protein 31
Alias SymbolsE3 ubiquitin-protein ligase RNF31;HOIL-1-interacting protein;HOIP;Paul;RING finger protein 31;RING-type E3 ubiquitin transferase RNF31;ZIBRA;zinc in-between-RING-finger ubiquitin-associated domain protein.
NCBI Gene Id55072
Protein NameE3 ubiquitin-protein ligase RNF31
Description of TargetE3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998).
Uniprot IDQ96EP0
Protein Accession #NP_001297261
Nucleotide Accession #NM_001310332
  1. What is the species homology for "RNF31 Antibody (OACA05890)"?

    The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".

  2. How long will it take to receive "RNF31 Antibody (OACA05890)"?

    This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".

  3. What buffer format is "RNF31 Antibody (OACA05890)" provided in?

    This item is provided in "Liquid".
    Additional format options may be available. For more information please contact info@avivasysbio.com.

  4. What are other names for "RNF31 Antibody (OACA05890)"?

    This target may also be called "E3 ubiquitin-protein ligase RNF31;HOIL-1-interacting protein;HOIP;Paul;RING finger protein 31;RING-type E3 ubiquitin transferase RNF31;ZIBRA;zinc in-between-RING-finger ubiquitin-associated domain protein." in publications.

  5. What is the shipping cost for "RNF31 Antibody (OACA05890)"?

    The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.

  6. What is the guarantee for "RNF31 Antibody (OACA05890)"?

    All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.

  7. Can I get bulk pricing for "RNF31 Antibody (OACA05890)"?

    You can get bulk pricing for this item by going here.

  8. What is the molecular weight of the protein?

    The molecular weight reported by Uniprot for this item is "".
    Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics.

  9. What protocols are available for "RNF31 Antibody (OACA05890)"?

    We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.

  10. What are positive controls for "RNF31"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  11. What are negative controls for "RNF31"?

    We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.

  12. What other proteins interact with "RNF31"?

    This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.

  13. What biological processes are associated with "RNF31"?

    This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.

  14. What cellular components are associated with "RNF31"?

    This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.

  15. What protein functions are associated with "RNF31"?

    This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.

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