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- $55: Antibody & Protein in US
- $55 + $25/Kit in US
- Contact us for international orders.
Datasheets/Manuals | Printable datasheet for RNF31 Antibody (OACA05890) (OACA05890) |
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Predicted Species Reactivity | Human |
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Product Format | Liquid |
Clonality | Polyclonal |
Isotype | IgG |
Host | Rabbit |
Conjugation | Unconjugated |
Application | Enzyme-linked immunosorbent assay|Immunofluorescence|Immunohistochemistry |
Reconstitution and Storage | -20°C or -80°C |
Immunogen | Recombinant Human E3 ubiquitin-protein ligase RNF31 protein (421-700AA) |
Purification | Protein G Purified |
Preservative | 0.03% Proclin 300 |
Formulation | 50% Glycerol, 0.01M PBS, PH 7.4 |
Gene Symbol | RNF31 |
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Gene Full Name | ring finger protein 31 |
Alias Symbols | E3 ubiquitin-protein ligase RNF31;HOIL-1-interacting protein;HOIP;Paul;RING finger protein 31;RING-type E3 ubiquitin transferase RNF31;ZIBRA;zinc in-between-RING-finger ubiquitin-associated domain protein. |
NCBI Gene Id | 55072 |
Protein Name | E3 ubiquitin-protein ligase RNF31 |
Description of Target | E3 ubiquitin-protein ligase component of the LUBAC complex which conjugates linear ('Met-1'-linked) polyubiquitin chains to substrates and plays a key role in NF-kappa-B activation and regulation of inflammation (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). LUBAC conjugates linear polyubiquitin to IKBKG and RIPK1 and is involved in activation of the canonical NF-kappa-B and the JNK signaling pathways (PubMed:17006537, PubMed:19136968, PubMed:20005846, PubMed:21455173, PubMed:21455180, PubMed:21455181, PubMed:22863777). Linear ubiquitination mediated by the LUBAC complex interferes with TNF-induced cell death and thereby prevents inflammation (PubMed:21455173). LUBAC is proposed to be recruited to the TNF-R1 signaling complex (TNF-RSC) following polyubiquitination of TNF-RSC components by BIRC2 and/or BIRC3 and to conjugate linear polyubiquitin to IKBKG and possibly other components contributing to the stability of the complex (PubMed:20005846). Together with otulin, the LUBAC complex regulates the canonical Wnt signaling during angiogenesis. Binds polyubiquitin of different linkage types (PubMed:23708998). |
Uniprot ID | Q96EP0 |
Protein Accession # | NP_001297261 |
Nucleotide Accession # | NM_001310332 |
- Protocol:
- Reconstitution & Storage Instructions
- Western Blotting/Immunoblotting (WB/IB) Protocol
- Immunohistochemistry (IHC) Protocol
- Immunocytochemistry (ICC) Protocol
- Enzyme-Linked ImmunoSorbent Assay (ELISA) Protocol
- Blocking Peptide Competition Protocol (BPCP)
- Immunoprecipitation (IP) Protocol
- Antibody Array (AA) Protocol
- Tips Information:
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See our General FAQ page.
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What is the species homology for "RNF31 Antibody (OACA05890)"?
The tested species reactivity for this item is "". This antibody is predicted to have homology to "Human".
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How long will it take to receive "RNF31 Antibody (OACA05890)"?
This item is available "Domestic: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks | International: Antibody & Kits: 2 weeks | Proteins: 4-6 weeks".
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What buffer format is "RNF31 Antibody (OACA05890)" provided in?
This item is provided in "Liquid".
Additional format options may be available. For more information please contact info@avivasysbio.com. -
What are other names for "RNF31 Antibody (OACA05890)"?
This target may also be called "E3 ubiquitin-protein ligase RNF31;HOIL-1-interacting protein;HOIP;Paul;RING finger protein 31;RING-type E3 ubiquitin transferase RNF31;ZIBRA;zinc in-between-RING-finger ubiquitin-associated domain protein." in publications.
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What is the shipping cost for "RNF31 Antibody (OACA05890)"?
The shipping cost for this item is $40 within the US. Please contact us for specific shipping prices for international orders.
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What is the guarantee for "RNF31 Antibody (OACA05890)"?
All Aviva products have been through rigorous validations and carry 100% satisfaction guarantee.
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Can I get bulk pricing for "RNF31 Antibody (OACA05890)"?
You can get bulk pricing for this item by going here.
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What is the molecular weight of the protein?
The molecular weight reported by Uniprot for this item is "".
Please note observed molecular weights in western blot applications may differ depending on a variety of protein characteristics. -
What protocols are available for "RNF31 Antibody (OACA05890)"?
We may have detailed protocol data avaialble for this item. To learn more, please view the "Protocols & Data" tab on the product page.
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What are positive controls for "RNF31"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What are negative controls for "RNF31"?
We have listed RNA Seq and gene expression data in the "Target Info" tab. You may be able to find adequate positive controls there.
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What other proteins interact with "RNF31"?
This protein has been reported to interact with "Protein Interactions". Please view the "Related Categories" tab on the product page for more information.
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What biological processes are associated with "RNF31"?
This protein has been associated with "Biological Processes". Please view the "Related Categories" tab on the product page for more information.
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What cellular components are associated with "RNF31"?
This protein has been associated with "Cellular Components". Please view the "Related Categories" tab on the product page for more information.
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What protein functions are associated with "RNF31"?
This protein has been associated with "Protein Functions". Please view the "Related Categories" tab on the product page for more information.