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Catalog No: OPCD06722
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OPCD06722
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Datasheets/ManualsPrintable datasheet for RNASEL Recombinant Protein (OPCD06722)
Product Info
Predicted Species ReactivityHomo sapiens|Human
Product FormatFreeze-dried Powder. PBS, pH7.4, containing 0.01% SKL, 5% Trehalose.
HostE.coli
ConjugationUnconjugated
ApplicationPositive control|Sodium sodecyl sulfate - polyacrylamide gel electrophoresis|Western blot
Additional InformationEndotoxin Level: < 1.0 EU per 1 ug (determined by the LAL method)
::Residues: Ile358-His583
Reconstitution and Storage2°C to 8°C|-80°C
Concentration200 ug/mL (prior to lyoph)
Purity> 95%
SourceE.coli
TagN-terminal His Tag
Gene SymbolRNASEL
Gene Full Nameribonuclease L
Alias Symbols2',5'-oligoisoadenylate synthetase-dependent;2-5A-dependent ribonuclease;2-5A-dependent RNase;interferon-induced 2-5A-dependent RNase;PRCA1;ribonuclease 4;Ribonuclease L;RNase L;RNS4.
NCBI Gene Id6041
Protein Name2-5A-dependent ribonuclease
Description of TargetEndoribonuclease that functions in the interferon (IFN) antiviral response. In INF treated and virus infected cells, RNASEL probably mediates its antiviral effects through a combination of direct cleavage of single-stranded viral RNAs, inhibition of protein synthesis through the degradation of rRNA, induction of apoptosis, and induction of other antiviral genes. RNASEL mediated apoptosis is the result of a JNK-dependent stress-response pathway leading to cytochrome c release from mitochondria and caspase-dependent apoptosis. Therefore, activation of RNASEL could lead to elimination of virus infected cells under some circumstances. In the crosstalk between autophagy and apoptosis proposed to induce autophagy as an early stress response to small double-stranded RNA and at later stages of prolonged stress to activate caspase-dependent proteolytic cleavage of BECN1 to terminate autophagy and promote apoptosis (PubMed:26263979). Might play a central role in the regulation of mRNA turnover (PubMed:11585831). Cleaves 3' of UpNp dimers, with preference for UU and UA sequences, to sets of discrete products ranging from between 4 and 22 nucleotides in length.
Uniprot IDQ05823
Protein Accession #NP_066956.1
Nucleotide Accession #NM_021133.3
Protein Size (# AA)Ile358~His583
Molecular Weight27kDa
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