RIPK3 Recombinant Protein (Mouse) (OPCA03079)

Catalog No: OPCA03079

Ripk3 Recombinant Protein (Mouse) (OPCA03079) in SDS-PAGE showing the molecular weight of approximately 55.32 kDa.

Ripk3 Recombinant Protein (Mouse) (OPCA03079) in SDS-PAGE showing the molecular weight of approximately 55.32 kDa.

Product Info

• Predicted Species Reactivity: Mouse|Mus musculus
• Product Format: Liquid 20mM Tris-HCl, 0.5M NaCl (pH 8.0), 50% glycerol
• Reconstitution and Storage: Store at -20°C; for extended storage, conserve at -20°C or -80°C. Store at 4°C for up to one week. Repeated freeze/thaw cycles are not recommended.
• Purification: Affinity purified using IMAC
• Concentration: Varies by lot. See vial for concentration.
• Purity: Greater than 90% as determined by SDS-PAGE.
• Protein Sequence: Full Length: MSSVKLWPTGASAVPLVSREELKKLEFVGKGGFGVVFRAHHRTWNHDVAVKIVNSKKISWEVKAMVNLRNENVLLLLGVTEDLQWDFVSGQALVTRFMENGSLAGLLQPECPRPWPLLCRLLQEVVLGMCYLHSLNPPLLHRDLKPSNILLDPELHAKLADFGLSTFQGGSQSGSGSGSGSRDSGGTLAYLDPELLFDVNLKASKASDVYSFGILVWAVLAGREAELVDKTSLIRETVCDRQSRPPLTELPPGSPETPGLEKLKELMIHCWGSQSENRPSFQDCEPKTNEVYNLVKDKVDAAVSEVKHYLSQHRSSGRNLSAREPSQRGTEMDCPRETMVSKMLDRLHLEEPSGPVPGKCPERQAQDTSVGPATPARTSSDPVAGTPQIPHTLPFRGTTPGPVFTETPGPHPQRNQGDGRHGTPWYPWTPPNPMTGPPALVFNNCSEVQIGNYNSLVAPPRTTASSSAKYDQAQFGRGRGWQPFHK
• Source: Yeast
• Tag: N-terminal 6xHis-tagged
• Reference: Mouse receptor interacting protein 3 does not contain a caspase-recruiting or a death domain but induces apoptosis and activates NF-kappaB.Pazdernik N.J., Donner D.B., Goebl M.G., Harrington M.A.Mol. Cell. Biol. 19:6500-6508(1999)
• Warning: For research use only.

Target Info

• Gene Symbol: Ripk3
• Gene Full Name: receptor-interacting serine-threonine kinase 3
• Alias Symbols: 2610528K09Rik;AW107945;mRIP3;R;receptor interacting protein 3;Receptor-interacting protein 3;receptor-interacting serine/threonine-protein kinase 3;Rip3;RIP-3;RIP-like protein kinase 3.
• NCBI Gene Id: 56532
• Protein Name: Receptor-interacting serine/threonine-protein kinase 3
• Description of Target: Essential for necroptosis, a programmed cell death process in response to death-inducing TNF-alpha family members. Upon induction of necrosis, RIPK3 interacts with, and phosphorylates RIPK1 and MLKL to form a necrosis-inducing complex. RIPK3 binds to and enhances the activity of three metabolic enzymes: GLUL, GLUD1, and PYGL. These metabolic enzymes may eventually stimulate the tricarboxylic acid cycle and oxidative phosphorylation, which could result in enhanced ROS production.
• Uniprot ID: Q9QZL0
• Protein Accession #: NP_064339.2
  
• Nucleotide Accession #: NM_019955.2
• Protein Size (# AA): 1-486aa
• Molecular Weight: 55 kDa