RIPK2 Antibody (Phospho-Ser176) (OASG06442)

Catalog No: OASG06442

Size:100 uL

Western Blot using 293

Product Info

• Predicted Species Reactivity: Human, Mouse
• Product Format: Liquid PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide.
• Clonality: Polyclonal
• Isotype: IgG
• Host: Rabbit
• Application: WB, IHC
• Additional Information: Tissue Specificity: Detected in heart, brain, placenta, lung, peripheral blood leukocytes, spleen, kidney, testis, prostate, pancreas and lymph node.
  Cellular Location: Cytoplasm.
• Reconstitution and Storage: Store at -20°C for 1 year. Avoid repeated freeze/thaw cycles.
• Immunogen: Synthesized peptide derived from human RIP2 around the phosphorylation site of S176. Location: 120-200aa.
• Purification: The antibody was affinity-purified from rabbit antiserum by affinity-chromatography.
• Concentration: 1 mg/ml
• Target Post-Translational Modification: Phospho-Ser176
• Specificity: Phospho-RIP2 (S176) Polyclonal Antibody detects endogenous levels of RIP2 protein only when phosphorylated at S176.
• Application Info: WB: 1:500~2000
  IHC: 1:100~300
  ELISA: 1:40000

Target Info

• Gene Symbol: RIPK2
• Gene Full Name: receptor-interacting serine-threonine kinase 2
• Alias Symbols: CCK, RICK, RIP2, CARD3, GIG30, CARDIAK
• NCBI Gene Id: 8767; 192656;
• Description of Target: RIP2 is a protein encoded by the RIPK2 gene. RIP2 is localised to the cytoplasm. It is involved in activated TLR4 signalling, p75 NTR receptor-mediated signalling, toll-like receptor signalling pathways and cytokine signalling in immune system. It is a serine/threonine/tyrosine kinase that contains a C-terminal caspase activation and recruitment domain and plays an essential role in modulation of innate and adaptive immune responses. RIP2 is expressed in the heart, brain, placenta, lung, peripheral blood leukocytes, spleen and kidney. Mutations in the RIPK2 gene may result in x-linked lymphoproliferative syndrome and human granulocytic anaplasmosis. STJ90957 was affinity-purified from rabbit antiserum by affinity-chromatography using epitope-specific immunogen. This primary antibody specifically binds to endogenous RIP2 protein which only binds about S176 when S176 is phosphorylated.
• Uniprot ID: O43353, P58801