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RHOA Antibody (OAAJ06549)

100 uL
$289.00
In Stock
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Predicted Species Reactivity:
Human, Mouse, Rat
Product Format:
Liquid
Clonality:
Polyclonal
Host:
Rabbit
Application:
WB
Reconstitution and Storage:
Store at +4C. For long term storage, aliquot and store at -20C. Avoid freeze/thaw cycles.
Gene Symbol:
RHOA
NCBI Gene Id:
387
Protein Name:
Transforming protein RhoA
Swissprot Id:
P61586
Protein Accession #:
NP_001300870
Nucleotide Accession #:
NM_001313941
Alias Symbols:
ARH12, ARHA, h12, Rho12, RHO12, RhoA, Rho cDNA clone 12, RHOH12, Transforming protein RhoA
Description of Target:
Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. Stimulates PKN2 kinase activity. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. Required for the apical junction formation of keratinocyte cell-cell adhesion. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization . Regulates KCNA2 potassium channel activity by reducing its location at the cell surface in response to CHRM1 activation; promotes KCNA2 endocytosis.
Molecular Weight:
22 kDa
Purification:
Immunogen affinity chromatography
Tissue Tool:
Find tissues and cell lines supported by DNA array analysis to express RHOA.
RNA Seq:
Find tissues and cell lines supported by RNA-seq analysis to express RHOA.
Immunogen:
Center-peptideof human RhoA
Concentration:
1 mg/mL
Datasheets/Manuals:
Printable datasheet for anti-RHOA (OAAJ06549) antibody

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