Search Antibody, Protein, and ELISA Kit Solutions

WNT Signaling

The Wnt pathway involves a large number of proteins which regulate cell-to-cell interactions during embryogenesis and cancer. The signal initiates when Wnt proteins bind to Frizzled receptors on the cell surface. The signal then is transduced to beta-catenin and enters the nucleus to form a complex to activate transcripThe Wnt signaling pathway is a signal transduction cascade that plays a pivotal role in numerous biological processes, including stem cell differentiation, axon guidance, and malignant transformation. Canonical Wnt signaling involves binding of Wnt proteins to Frizzled family receptors on the cell surface, which leads to activation of Dishevelled family proteins. This activation prevents the degradation of β-catenin, leading to its accumulation in the cytoplasm. The cytoplasmic accumulation and stabilization of β-catenin allow some β-catenin molecules to enter the nucleus where they interact with TCF/LEF family transcription factors and alter gene expression patterns. In addition to the canonical Wnt pathway, two non-canonical pathways have been well described, namely the planar cell polarity pathway and the Wnt/calcium pathway. These two pathways differ from the canonical pathway in various ways, including the ligands that activate each. Wnt proteins play important roles in the normal physiology of adult tissues and aberrant Wnt signaling can lead to many known human diseases, including Familial Exudative Vitreoretinopathy, Tetra-amelia, and colon cancer.[1]

1.Logan CY and Nusse R. 2004. The Wnt signaling pathway in development and disease. Annu Rev Cell Dev Biol.20:781-810.

See Related Product List Below Pathway Image

Wnt signaling pathway image by Aviva Systems Biology

Click here to download PDF and related products

Back To the Top

Page of 5

Showing 1 - 30 of 146
  •  
    LEF1 Antibody (OASA06330)

    LEF1 Antibody (OASA06330)

    Protein Name:Lymphoid enhancer-binding factor 1
    Catalog #:OASA06330
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $530.00
  •  
    PPP2R5D Antibody (OASA06402)

    PPP2R5D Antibody (OASA06402)

    Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit delta isoform
    Catalog #:OASA06402
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    SFRP1 Antibody (OASA08759)

    SFRP1 Antibody (OASA08759)

    Protein Name:Secreted frizzled-related protein 1
    Catalog #:OASA08759
    Type: pAb
    Reacts with: Human
    Application: ELISA, IHC-FFPE, WB
    Product Size: 50ug
    Price (USD): $710.00
  •  
    SIAH1 Antibody (OASA06445)

    SIAH1 Antibody (OASA06445)

    Protein Name:E3 ubiquitin-protein ligase SIAH1
    Catalog #:OASA06445
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $545.00
  •  
    EP300 Antibody (OASA08061)

    EP300 Antibody (OASA08061)

    Protein Name:Histone acetyltransferase p300
    Catalog #:OASA08061
    Type: pAb
    Reacts with: Human
    Application: IP, WB
    Product Size: 0.1mg
    Price (USD): $640.00
  •  
    RAC2 Antibody (OASA06415)

    RAC2 Antibody (OASA06415)

    Protein Name:Ras-related C3 botulinum toxin substrate 2
    Catalog #:OASA06415
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $575.00
  •  
    WNT1 Antibody (OASA08277)

    WNT1 Antibody (OASA08277)

    Protein Name:Proto-oncogene Wnt-1
    Catalog #:OASA08277
    Type: pAb
    Reacts with: Human
    Application: ELISA, WB
    Product Size: 0.1mg
    Price (USD): $575.00
  •  
    PPP2R5B Antibody (OASA06400)

    PPP2R5B Antibody (OASA06400)

    Protein Name:Serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
    Catalog #:OASA06400
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $560.00
  •  
    PPP2CA Antibody (OASA06410)

    PPP2CA Antibody (OASA06410)

    Protein Name:Serine/threonine-protein phosphatase 2A catalytic subunit alpha isoform
    Catalog #:OASA06410
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $790.00
  •  
    CCND3 Antibody (OASA02653)

    CCND3 Antibody (OASA02653)

    Protein Name:G1/S-specific cyclin-D3
    Catalog #:OASA02653
    Type: mAb
    Reacts with: Human
    Application: IHC-AFF, IHC-FFPE, WB
    Product Size: 1ml
    Price (USD): $1,130.00
  •  
    Gsk3b Antibody (OASA07320)

    Gsk3b Antibody (OASA07320)

    Protein Name:Glycogen synthase kinase-3 beta
    Catalog #:OASA07320
    Type: pAb
    Reacts with: Rat
    Application: WB
    Product Size: 0.1ml
    Price (USD): $770.00
  •  
    SMAD2 Antibody (OASA06336)

    SMAD2 Antibody (OASA06336)

    Protein Name:Mothers against decapentaplegic homolog 2
    Catalog #:OASA06336
    Type: pAb
    Reacts with: Human
    Application: WB
    Product Size: 0.1mg
    Price (USD): $690.00

Page of 5

Showing 1 - 30 of 146